2007
DOI: 10.1016/j.surneu.2006.12.054
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Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats

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Cited by 51 publications
(39 citation statements)
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“…Similar findings were also observed in a previous study, though these results were limited by extensive swelling and collapse of the biomaterial poly(lactic co-glycolic acid) (PLGA) in the study. CMAP examinations offer an important index for the conduction function of peripheral nerve [2,[28][29][30][31]. In this study, we observed the highest CMAP amplitude of autograft repair in both plantar foot muscles and dorsal muscles.…”
Section: Discussionsupporting
confidence: 58%
“…Similar findings were also observed in a previous study, though these results were limited by extensive swelling and collapse of the biomaterial poly(lactic co-glycolic acid) (PLGA) in the study. CMAP examinations offer an important index for the conduction function of peripheral nerve [2,[28][29][30][31]. In this study, we observed the highest CMAP amplitude of autograft repair in both plantar foot muscles and dorsal muscles.…”
Section: Discussionsupporting
confidence: 58%
“…Citicoline has been suggested to reduce brain injury in both experimental and clinical studies (2). In a previous study from our laboratory, we reported that topically-administered citicoline after primary saturation following peripheral nerve incision significantly increased axonal regeneration by preventing scar tissue formation (31). We determined, in a follow-up study (6) that was designed to investigate the effects of topically-administered citicoline, as well as its metabolites cytidine, choline, and cytidine plus choline following sciatic nerve incision and primary anastomosis that cytidine plus choline was as efficient as citicoline in reducing scar tissue formation and increasing functional recovery by potentiating axonal regeneration.…”
Section: Figure 5: Graphs Depicting Mean Density (A) and Total Numbermentioning
confidence: 84%
“…In a previous study performed in our laboratory (31) topical citicoline was shown to decrease perineural scar tissue and to increase axonal regeneration as well as functional recovery in rats undergoing primary repair following peripheral nerve damage. In a follow-up study, we examined the effects of topically-administered citicoline, cytidine, choline, and cytidine plus choline in a primary anastomosis model of the sciatic nerve and found that cytidine plus choline and citicoline were efficient in preventing scar tissue formation and that cytidine plus choline increased the functional recovery by potentiating axonal regeneration (6).…”
Section: Introductionmentioning
confidence: 85%
“…Data obtained in our previous studies on citicoline's effects on promoting regeneration of peripheral nerves subjected to immediate section suturing type surgery and reducing postoperative scarring, and recent similar observations encouraged us to test citicoline in prevention of epidural fibrosis after lumbar disc surgery (6,12,36). Hence, the purpose of our study was to investigate local and systemic effectiveness of citicoline on epidural fibrosis in a rat model of laminotomy and discectomy.…”
Section: Savran M Et Al: Prevention Of Epidural Fibrosis In Ratsmentioning
confidence: 85%