CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis

Howlin, Jillian; McBryan, Jean; Napoletano, Silvia; Lambe, Teresa; McArdle, Emmett; Shioda, Toshishiro; Martin, Finian

doi:10.1038/sj.onc.1209183

Cited by 49 publications

(60 citation statements)

References 46 publications

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“…Both proteins, in agreement with previous reports, were expressed in some but not all epithelial cells of the ducts in an on/off pattern (Zeps et al, 1998;Howlin et al, 2006b). ERa appeared nuclear, while CITED1 was predominantly cytoplasmic and weakly nuclear.…”

Section: Co-regulation Of Pubertal Gene Expression By Era and Cited1supporting

confidence: 80%

“…Expression of all of these genes was found to increase in our data set ( Figure 1c). Similarly, KO mice have shown that CITED1, possibly through regulation of oestrogen signalling, is a mediator of pubertal ductal outgrowth and our data confirmed the increase in expression of CITED1 during normal pubertal mammary gland development (Figure 1c;and Howlin et al, 2006b). …”

Section: Expression Microarray Analysis Of Pubertal Mammary Gland Devsupporting

confidence: 77%

“…Cross comparison of the data sets identified several members of the Wnt, TGFb and oestrogen-signalling pathways, which have altered expression levels in CITED1 KO mice relative to controls (Supplementary Data 2, 3 and Table 1). CITED1 KO mice display reduced ductal outgrowth, altered branch patterning and a reduced number of TEBs during puberty ( Figure 4A; Howlin et al, 2006b). The comparative gene expression data therefore support the building evidence for an important role for Wnt, TGFb and oestrogen signalling in normal pubertal mammary gland development as well as a potential role for CITED1 in regulating these pathways.…”

Section: Era-cited1 Pathway In Breast Tumours J Mcbryan Et Alsupporting

confidence: 55%

“…It has previously been reported that Areg expression may contribute to abnormal development in the older, mature mammary gland (Herrington et al, 1997). Owing to the growth promoting effects exhibited by both Areg and CITED1 (Howlin et al, 2006b), it is conceivable that the high level of expression of these genes may contribute to the increased susceptibility of the nulliparous gland to cancer (Kenney et al, 1996;D'Cruz et al, 2002;Howlin et al, 2006b).…”

Section: Discussionmentioning

confidence: 99%

“…The Wnt, TGFb and oestrogen-signalling pathways are all known targets for transcriptional co-regulation by CITED1 (Yahata et al, 2001;Plisov et al, 2005). We have previously identified gene expression changes associated with the loss of CITED1 by comparing expression levels between 6-week CITED1 KO and control mammary glands (Howlin et al, 2006b). Cross comparison of the data sets identified several members of the Wnt, TGFb and oestrogen-signalling pathways, which have altered expression levels in CITED1 KO mice relative to controls (Supplementary Data 2, 3 and Table 1).…”

Section: Era-cited1 Pathway In Breast Tumours J Mcbryan Et Almentioning

confidence: 99%

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ERα–CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis

et al. 2007

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Expression microarray analysis identified over 930 genes regulated during puberty in the mouse mammary gland. Most prominent were genes whose expression increased in parallel with pubertal development and remained high thereafter. Members of the Wnt, transforming growth factor-b and oestrogen-signalling pathways were significantly overrepresented. Comparison to expression data from CITED1 knockout mice identified a subset of oestrogen-responsive genes displaying altered expression in the absence of CITED1. Included in this subset are stanniocalcin2 (Stc2) and amphiregulin (Areg). Chromatin immunoprecipitation revealed that ERa binds to oestrogen response elements in both the Stc2 and Areg genes in the mammary gland during puberty. Additionally, CITED1 and ERa localize to the same epithelial cells of the pubertal mammary gland, supporting a role for interaction of these two proteins during normal development. In a human breast cancer data set, expression of Stc2, Areg and CITED1 parallel that of ERa. Similar to ERa, CITED1 expression correlates with good outcome in breast cancer, implying that potential maintenance of the ERa-CITED1 co-regulated signalling pathway in breast tumours can indicate good prognosis.

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Section: Co-regulation Of Pubertal Gene Expression By Era and Cited1supporting

confidence: 80%

Section: Expression Microarray Analysis Of Pubertal Mammary Gland Devsupporting

confidence: 77%

Section: Era-cited1 Pathway In Breast Tumours J Mcbryan Et Alsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Era-cited1 Pathway In Breast Tumours J Mcbryan Et Almentioning

confidence: 99%

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ERα–CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis

et al. 2007

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Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis

Boyle

Shioda

Perantoni

et al. 2007

Developmental Dynamics

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Early kidney development in mammals is characterized by reciprocal tissue interaction between the ureteric bud and the metanephric mesenchyme. The coordinated response to this interaction is regulated largely at the transcriptional level. Here, we investigate the expression and function of Cited1, a transcriptional cofactor that we have previously implicated in kidney development. We show that Cited1 is expressed in the metanephric mesenchyme after invasion of the ureteric bud and that its expression is limited to the cap mesenchyme, those cells that aggregate most tightly around the tip of the ureteric bud and give rise to nephronic epithelium of the adult kidney. Cited1 is down-regulated during the initial stages of epithelial conversion and is not expressed past this progenitor stage. Despite its unique expression pattern, deletion of Cited1 does not disrupt kidney development. We hypothesized that this finding was due to functional redundancy with other members of this gene family. The expression pattern of Cited2 overlaps that of Cited1, but its deletion, either alone or in combination with Cited1, does not disrupt epithelial differentiation of the metanephric mesenchyme. From these studies, we conclude that Cited1 and 2 are dynamically expressed during kidney development, but are not required for nephrogenesis. Developmental Dynamics 236:2321-2330, 2007.

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A bioinformatics approach for identifying candidate transcriptional regulators of mesenchyme‐to‐epithelium transitions in mouse embryos

Bard

Lam

Aitken

2008

Developmental Dynamics

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This article reports a method for identifying groups of genes associated with tissues undergoing a particular process during mouse development. Given the Theiler stage at which each tissue starts the process, Boolean intersection analysis identifies genes expressed in some or all of these tissues both before the process starts and once it has started. This analysis is implemented in GXD-search; this tool downloads appropriate gene sets from GXD, the mouse gene expression database, and performs the calculations. Applied to mesenchyme-to-epithelium transitions (MET), GXD-search has identified Crabp1 and six transcriptional regulators (Cited1, Cited2, Meox1, Lhx1, Foxc1, and Foxc2) that are usually expressed in tissues about to undergo this process. Expression pattern analysis of these transcriptional regulators, mutations in each of which affect epithelial development, shows that this gene set is expressed in no other tissues and they are, thus, candidates for regulating MET. GXD-search is downloadable from http:// www.aiai.ed.ac.uk/project/biosphere/GXD-search.html. Developmental Dynamics 237:2748 -2754, 2008.

show abstract

CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis

Cited by 49 publications

References 46 publications

ERα–CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis

ERα–CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis

Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis

A bioinformatics approach for identifying candidate transcriptional regulators of mesenchyme‐to‐epithelium transitions in mouse embryos

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