Citalopram-Induced Parkinsonian Syndrome

Miletić, Vesna; Relja, Maja

doi:10.1097/wnf.0b013e318210ea3e

Cited by 15 publications

(2 citation statements)

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“…In this reported case, a 37-year-old female patient with paranoid schizophrenia developed severe Parkinsonian symptoms after one month of aripiprazole treatment at 10mg per day, which were completely resolved within 5 days after reducing the aripiprazole dosage to 5mg per day,underlining the significance of vigilant monitoring and appropriate dosage adjustments to manage adverse effects effectively [50,51].…”

Section: Case Report: Aripiprazole-induced Parkinsonian Symptoms In A...mentioning

confidence: 87%

“…In this reported case, a 67-year-old woman developed a sudden-onset parkinsonian syndrome just 2 weeks after initiating citalopram, experiencing a complete recovery from these symptoms after discontinuation of the medication, highlighting the importance of recognizing and addressing adverse reactions associated with citalopram use [41].…”

Section: Case Report: Citalopram-induced Sudden-onset Parkinsonian Sy...mentioning

confidence: 92%

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Drug induced Parkinson’s: A comprehensive review of the issues and measures required to tackle the same

Birla,

Kumar R,

Potale

et al. 2024

BIO Web Conf.

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Drug-inducedParkinsonism(DIP) closelyresemblesParkinson'sdisease(PD)inmotorsymptoms butiscausedbyspecificmedicationsdisruptingdopaminereceptorsandneurotransmitterbalance. PD involves a complex interplay of genetic, environmental, and biochemical factors resulting in the gradual degeneration of dopaminergic neurons. Environmental toxins and genetic mutations, such as LRRK2 and SNCA, contribute to the risk of developing PD. DIP primarily occurs due to the obstruction of dopamine receptors by certain drugs, notably antipsychotics and antiemetics, affecting dopamine transmission and causing Parkinsonian symptoms. Toxin-induced Parkinsonism(TIP)arisesfromexposuretosubstanceslikemanganese,herbicides,pesticides,and specific drugs, disrupting dopaminergic pathways and altering neurotransmission. This study examines various cases of DIP, emphasizing the significance of timely identification and intervention. A thorough understanding and proactive management of DIP are crucial for alleviatingsymptomsandimprovingpatientoutcomes.Healthcareprofessionalsneedtodiligently monitor patients using medications associated with DIP, adjust treatment plans, and educate patientsaboutpotentialsideeffects. Further researchisimperativetounravelthepathophysiology of DIP, considering genetic, environmental, and drug-related factors, to enhance clinical practices and optimize patient care. Addressing DIP requires a multifaceted approach, including early recognition, thoughtful management, and patient-centred care.

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Section: Case Report: Aripiprazole-induced Parkinsonian Symptoms In A...mentioning

confidence: 87%

Section: Case Report: Citalopram-induced Sudden-onset Parkinsonian Sy...mentioning

confidence: 92%