Citalopram-Associated SIADH

Barclay, Teresa S; Lee, Audrey J

doi:10.1345/1542-6270(2002)036<1558:cas>2.0.co;2

Cited by 13 publications

(27 citation statements)

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“…The highest risk occurs in the first month of treatment [38], with citalopram between day 6 and 20 on average [39]. Fabian et al investigated the occurrence of hyponatremia in older patients after the administration of paroxetine.…”

Section: Siadh and Antidepressantsmentioning

confidence: 99%

“…However, the case was described when SIADH developed after 16 months of paroxetine inclusion [41]. Analysis of selected cases shows that after the use of antidepressants hyponatremia may develop suddenly, so it is advantageous to monitor electrolyte levels at the beginning of treatment [38,39,41].…”

Section: Siadh and Antidepressantsmentioning

confidence: 99%

“…Największe ryzyko występuje w pierwszym miesiącu leczenia [38], w przypadku citalopramu średnio między 6 a 20 dniem stosowania [39]. Fabian i wsp.…”

Section: Przyczynyunclassified

“…Opisano jednak przypadek, gdy SIADH rozwinął się dopiero po 16 miesiącach od włączenia paroksetyny [41]. Analiza wybranych przypadków pozwala stwierdzić, że po zastosowaniu leków przeciwdepresyjnych hiponatremia może rozwinąć się nagle, korzystne jest zatem monitorowanie poziomu elektrolitów na początku leczenia [38,39,41].…”

Section: Przyczynyunclassified

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Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

Stelmach

Hołownia

Słotwiński

et al. 2017

Current Problems of Psychiatry

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Introduction. Hyponatremia is an important part of psychiatric practice. In order to analyze its causes and symptoms, the literature on hyponatremia in psychiatric patients has been reviewed. The work has been divided into two separate manuscripts. In the first one the authors discuss the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and hyponatremia occurring with the use of psychotropic drugs (antidepressants, antipsychotics, normotimics), while the second paper discusses research on psychogenic polydipsia. The causes of hyponatremia in patients treated in psychiatric wards include: water intoxication associated with polydipsia, somatic comorbidities, side effect of internal medicine and psychiatric drugs. The most common mechanism leading in these cases to hyponatremia is the syndrome of inappropriate secretion of vasopressin (SIADH). The SIADH syndrome is a group of symptoms, first described in 1967 by Schwartz and Bartter in The American Journal of Medicine, which results from the hypersecretion of antidiuretic hormone, also called vasopressin, which causes patients to develop normovolemic hyponatremia. The phenomenon of drug-induced hyponatremia in psychiatric practice is generally observed with the use of antidepressants, antipsychotics and anti-epileptic drugs (used in psychiatry as normotimic drugs).Aim and method. The first manuscript includes a review of literature on the syndrome of inappropriate secretion of vasopressin (SIADH) and hyponatremia occurring after the use of psychotropic drugs, and is divided into two subsections: 1. The syndrome of inappropriate secretion of vasopressin (SIADH), 2. Hyponatremia and psychotropic drugs (antidepressants, antipsychotics, normotimics).Conclusion. In the view of the reviewed literature it is extremely important to control the natremia level during pharmacotherapy using the above mentioned drugs, especially in the initial period of therapy.

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Section: Siadh and Antidepressantsmentioning

confidence: 99%

Section: Siadh and Antidepressantsmentioning

confidence: 99%

“…Największe ryzyko występuje w pierwszym miesiącu leczenia [38], w przypadku citalopramu średnio między 6 a 20 dniem stosowania [39]. Fabian i wsp.…”

Section: Przyczynyunclassified

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Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

Stelmach

Hołownia

Słotwiński

et al. 2017

Current Problems of Psychiatry

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“…Since the late 1980s a number of selective serotoninreuptake inhibitor (SSRI) antidepressants have been introduced in Western countries (1)(2)(3)(4)(5)(6)(7)(8). These drugs have been used widely for depressed patients because of fewer side effects and relative safety compared with tricyclic agents in potential overdose situations.…”

Section: Introductionmentioning

confidence: 99%

Hyponatremia Upon Resumption of Paroxetine Therapy

et al. 2005

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We present a 79-year-old woman with severe hyponatremia secondary to resumption of treatment with paroxetine, a selective serotonin-reuptake inhibitor antidepressant. Confusion and fatigue followed re-initiation of paroxetine after a 3-month hiatus. Hyponatremia, serum hypoosmolality, and urine hyperosmolality strongly suggested the syndrome of inappropriate secretion of antidiuretic hormone. Hyponatremia was quickly resolved after discontinuation of paroxetine and initiation of intravenous normal saline infusion together with oral fluid restriction. This case underscores the importance of monitoring serum sodium in elderly patients taking paroxetine, whether this represents a new prescription or reintroduction of the drug.

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Vigilanzminderung und ausgeprägte Hyponatriämie bei einer 67-jährigen Patientin

et al. 2006

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A 67-year-old female patient with known depression was admitted to the intensive care unit with severe hyponatraemia (105 mmol/l) and somnolence caused by inadequate antidiuretic hormone secretion (SIADH) syndrome after starting therapy with the selective serotonin reuptake inhibitor (SSRI) Citalopram. This medication was stopped, and the hyponatraemia was carefully treated with fluid restriction and diuretics. Seven days later, the patient was discharged to a psychiatric ward with normal sodium levels and markedly improved vigilance. Given the increased use of SSRI for medical treatment of depression, the risk factors of this rare but potentially life-threatening complication and the diagnostic and therapeutic options are discussed.

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Citalopram-Associated SIADH

Cited by 13 publications

References 0 publications

Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

Hyponatremia Upon Resumption of Paroxetine Therapy

Vigilanzminderung und ausgeprägte Hyponatriämie bei einer 67-jährigen Patientin

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