Citalopram and Mania

Dullur, Pravin; Srinath, Shoba; Girimaji, Satish Chandra; Seshadri, Shekhar

doi:10.1097/01.chi.0000128831.13997.e3

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…There are many case studies describing antidepressant-induced mania in children and adolescents treated with SSRIs, including citalopram (five cases) [53,54]; fluoxetine (11 cases) [55–59]; paroxetine (seven cases) [60–63]; sertraline (five cases) [64–67]; and venlafaxine (a serotonin–norepinephrine reuptake inhibitor; one case) [69]. These reports describe a young person treated for anxiety or depression (and in one case, epilepsy) [53], who developed symptoms of mania or hypomania after treatment with an SSRI for periods of time that were typically short (8 weeks or fewer) [54,56–62,64–66], but were sometimes long (from 5 months to a year) [53,57,58,63].…”

Section: Review Of the Evidence For Antidepressants Potentially Inducmentioning

confidence: 99%

“…These reports describe a young person treated for anxiety or depression (and in one case, epilepsy) [53], who developed symptoms of mania or hypomania after treatment with an SSRI for periods of time that were typically short (8 weeks or fewer) [54,56–62,64–66], but were sometimes long (from 5 months to a year) [53,57,58,63]. The median time to onset of mania was 21 days, with a range from 2 to 365 days.…”

Section: Review Of the Evidence For Antidepressants Potentially Inducmentioning

confidence: 99%

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Antidepressant-Coincident Mania in Children and Adolescents Treated with Selective Serotonin Reuptake Inhibitors

2008

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Several factors have amplified concern about the possibility that antidepressant medication may contribute to induction of pediatric mania. These include the high rate of antidepressant medication prescription, the recent surge in the rate of diagnosis of pediatric bipolar disorder in the USA, and a growing number of case reports and clinical studies showing coincidence of manic symptoms with antidepressant pharmacotherapy in both youths and adults. However, the question of how medications and manic symptoms might be related is complicated, and decisive research studies with rigorous designs for evaluating the issues have not been published. The situation makes it difficult for practitioners to make good, evidence-based decisions. The scientific literature is ambiguous, and the stakes are high. We review the extant literature, offer seven different conceptual models of how medication and mania might be related, and comment on the evidence and clinical implications of each.

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Section: Review Of the Evidence For Antidepressants Potentially Inducmentioning

confidence: 99%

Section: Review Of the Evidence For Antidepressants Potentially Inducmentioning

confidence: 99%

Antidepressant-Coincident Mania in Children and Adolescents Treated with Selective Serotonin Reuptake Inhibitors

2008

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“…However, evidence (Akiskal et al, 1995;Faedda et al, 2004) suggests that other, "softer" forms of bipolarity commonly manifest in childhood and adolescence, and may later evolve into a full -blown bipolar I illness. High rates of antidepressant induced mania or hypomania (Akiskal's "bipolar III") have also been observed in this population (Pravin et al, 2004). These symptoms may occur even in the absence of overt mania or major depression once the illness is established (Stober et al, 1995).…”

Section: Further Questionsmentioning

confidence: 88%

Course and Outcome of Bipolar Affective Disorder in Children

Dullur

Rajkumar

Prabhuswamy

et al. 2005

Journal of Indian Association for Child and Adolescent Mental H

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Systematic studies of juvenile bipolar disorder have been carried out only in recent decades. Initially, Kraepelin considered bipolar disorder to be a relatively benign illness, However, recent literature suggests that bipolar disorder may present as chronic episodes with persistent deficits. Various studies, mainly naturalistic in design, have been carried out to answer questions regarding the course and outcome of bipolar disorder in children and adolescents. Indian findings differ considerably from those in Western populations. Western data suggest poor recovery from index episodes, especially in prepubertal bipolar children, longer episode duration, high rates of chronicity and rapid cycling, and a high relapse rate. Data from India, however, suggest that there is good recovery from the index episode, shorter episode duration, lower rates of chronicity, and rapid cycling. However, a higher relapse rate has been reported from Indian studies as well. The effectiveness of lithium as a prophylactic agent for childhood onset bipolar disorder needs to be reviewed.

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“…A 'dose-response' association is suggested in a few reports. [3][4][5] Symptoms usually resolve after stopping or reducing the dose of the medication.…”

Section: Discussionmentioning

confidence: 99%