2011
DOI: 10.1016/j.taap.2010.11.003
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Cisplatin triggers atrophy of skeletal C2C12 myotubes via impairment of Akt signalling pathway and subsequent increment activity of proteasome and autophagy systems

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Cited by 61 publications
(62 citation statements)
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“…Small ubiquitin-like modifier (SUMO) demodification, mediated by Senp3, is specifically associated with regulation of ribosome biogenesis (16). Gabarap is a known atrophy gene (24) and is upregulated in cisplatin-induced atrophy of C2C12 myotubes (9). Eukaryotic initiation factor 5a (Eif5a) undergoes a unique posttranslational modification (hypusination) that correlates with embryonic myogenic differentiation, and inhibition of EIF5A hypusination impairs C2C12 differentiation (33).…”
Section: Discussionmentioning
confidence: 99%
“…Small ubiquitin-like modifier (SUMO) demodification, mediated by Senp3, is specifically associated with regulation of ribosome biogenesis (16). Gabarap is a known atrophy gene (24) and is upregulated in cisplatin-induced atrophy of C2C12 myotubes (9). Eukaryotic initiation factor 5a (Eif5a) undergoes a unique posttranslational modification (hypusination) that correlates with embryonic myogenic differentiation, and inhibition of EIF5A hypusination impairs C2C12 differentiation (33).…”
Section: Discussionmentioning
confidence: 99%
“…CisPt was dissolved in 1.5% DMSO to obtain 5 mM stock solution and administered to cells for 4 h up to 24 h at 10 or 50  μ M as previously reported [4]. Control experiments were conducted in parallel with equivalent amount of DMSO.…”
Section: Methodsmentioning
confidence: 99%
“…C2C12 myoblasts were seeded on round coverslides (13 mm diameter) and induced to differentiate as previously [4]. After CisPt treatment cell culture was fixed for 20 min in 4% paraformaldehyde in PBS and permeabilized for 5 min with 0.1% Triton X-100.…”
Section: Methodsmentioning
confidence: 99%
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“…It is also an antineoplastic drug that causes an array of adverse effects on various organs and tissues (3). Nephrotoxicity is one of the major side-effects of cisplatin chemotherapy (4) limiting the promising efficacy of cisplatin (5).…”
Section: Introductionmentioning
confidence: 99%