Cisplatin treatment modulates Annexin A1 and inhibitor of differentiation to DNA 1 expression in cervical cancer cells

Prates, Janesly; Moreli, Jusciéle Brogin; Gimenes, Alexandre Dantas; Biselli, Joice Matos; D'Ávila, Solange Corrêa Garcia Pires; Sandri, Silvana; Farsky, Sandra Helena Poliselli; Rodrigues-Lisoni, Flávia Cristina; Oliani, Sônia Maria

doi:10.1016/j.biopha.2020.110331

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…Finally, 75 TFs were acquired with the standard (|correlation|>0.35 and p-value <0.001). The Cytoscape software [ 18 ] was used to visualize the relation between ANXA1 and TFs. Finally, we divided the PTC patients into high ANXA1 expression group and low ANXA1 expression group by the median score and got the different expression genes (DEGs) by the ‘DESeq2’ package to explore the gene ontology (GO) analysis as well as the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis through the package ‘clusterProfiler’ and ‘GSEA’.…”

Section: Methodsmentioning

confidence: 99%

ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma

et al. 2021

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Thyroid carcinoma is one of the most common endocrine malignancies, in which papillary thyroid carcinoma (PTC) is the main pathotype. ANXA1 plays a significant role in many cancer types, but how it works in PTC has not been identified. MYC is a common transcript factor involved in tumorigenesis, development, invasion, and metastasis. The relation between ANXA1 and MYC has not been proved in PTC. In this study, firstly, we analyzed the expression and prognostic value of ANXA1 in pan-cancer using the data from the UCSC database. Then we explore the role of ANXA1 in PTC, including expression, prognostic value, and immune infiltration. In addition, we evaluated the relation between ANXA1 and the transcription factor MYC. Finally, we identified the expression of ANXA1 and MYC and then evaluated their function associated with proliferation and apoptosis in PTC cell lines by CCK8 proliferation and flow cytometry apoptosis experiment. We found that ANXA1 is up-regulated in PTC comparing with normal patients. High expression of ANXA1 was associated with adverse overall survival of PTC. ANXA1 may be regulated by MYC to promote the proliferation of PTC. MYC may regulate the expression of ANXA and thus affect the proliferation of PTC.

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Section: Methodsmentioning

confidence: 99%

ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma

et al. 2021

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“…The protective anti-inflammatory action of ANXA1 has since been demonstrated in several models, including arthritis, heterologous skin transplantation, cancer, eye allergy, heart failure, lung injury, nonalcoholic steatosis, myocardial infarction, and skeletal muscle injury [19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Anxa1 and Inflammatory Processesmentioning

confidence: 99%

ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

Sousa

Santos

Teixeira

et al. 2022

Cells

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The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers and/or therapeutic purposes. ANXA1 is found in the plasma membrane, cytoplasm, and nucleus, being described at low levels in the nuclear and cytoplasmic compartments of placental cells related to gestational diabetic diseases, and its translocation from the cytoplasm to the nucleus has been associated with a response to DNA damage. The approaches presented here open pathways for reflection upon, and intrinsic clarification of, the modulating action of this protein in the response to genetic material damage, as well as its level of expression and cellular localization. The objective of this study is to arouse interest, with an emphasis on the mechanisms of nuclear translocation of ANXA1, which remain underexplored and may be beneficial in new inflammatory therapies.

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“…However, ANXA1 may also exert antiproliferative effects, as studies have shown that it is related to the sustained activation of the mitogen-activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) signaling pathway, resulting in the destruction of the actin cytoskeleton and the inhibition of cyclin D1, thereby reducing the proliferation of A549 lung cancer cells and RAW264.7 macrophages ( 45 ). ANXA1 also inhibits the proliferation of OSCC ( 23 ), human laryngeal squamous cell carcinoma ( 46 ), cervical cancer ( 47 ), BC ( 48 ), and GC ( 34 ) cells. Its antitumor effect is associated with the activation of FPRs and inhibition of miR-196a in a negative feedback loop through NF-kB and c-Myc ( 46 , 48 ).…”

Section: Anxa1mentioning

confidence: 99%

Annexin A1 affects tumor metastasis through epithelial-mesenchymal transition: a narrative review

Zheng¹,

Li²,

Wang³

et al. 2022

Transl Cancer Res

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Background and Objective: Annexin A1 (annexin I, ANXA1), the first discovered member of the annexin superfamily, plays important roles in tumor development, invasion, metastasis, apoptosis and drug resistance based on tumor type-specific patterns of expression. The acquisition of the epithelialmesenchymal transition (EMT) characteristics is an essential mechanism of metastasis because they increase the mobility and invasiveness of cancer cells. Cancer invasion and metastasis remain major health problems worldwide. Elucidating the role and mechanism of ANXA1 in the occurrence of EMT will help advance the development of novel therapeutic strategies. Hence, this review aims to attract everyone's attention to the important role of ANXA1 in tumors and provide new ideas for clinical tumor treatment. Methods:The PubMed database was mainly used to search for various English research papers and reviews related to the role of ANXA1 in tumors and EMT published from November 1994 to April 2022. The search terms used mainly include ANXA1, EMT, tumor, cancer, carcinoma, and mechanism.

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Cisplatin treatment modulates Annexin A1 and inhibitor of differentiation to DNA 1 expression in cervical cancer cells

Cited by 5 publications

References 42 publications

ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma

ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma

ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

Annexin A1 affects tumor metastasis through epithelial-mesenchymal transition: a narrative review

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