2022
DOI: 10.1101/2022.07.06.498982
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Cisplatin toxicity is mediated by direct binding to TLR4 through a mechanism that is distinct from metal allergens

Abstract: Cisplatin is an effective chemotherapeutic agent, yet its use is limited by several adverse drug reactions, known as cisplatin-induced toxicities (CITs). We recently demonstrated that cisplatin could elicit pro-inflammatory responses associated with CITs through Toll-like Receptor 4 (TLR4). TLR4 is best recognized for binding bacterial lipopolysaccharide (LPS) via its coreceptor, MD-2. TLR4 is also proposed to directly bind transition metals, such as nickel. Little is known about the nature of the cisplatin-TL… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 47 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?