Cisplatin Suppository: Preparation, Release Characteristics and Clinical Evaluation.

Nishioka, Yasuhiko; Kyotani, Shojiro; Kusunose, Masahiko; Mimoto, Hisashi; Hamada, Takashi; Asai, Masafusa; Sagara, Yusuke

doi:10.1248/cpb.39.1518

Cited by 4 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More than 70% of CDDP was released from the hydrogels in 2 days. The fast CDDP release from the hydrogels in vitro may be attributed to the enhanced solubility of CDDP, reduced substitution activity of Cl – ions in CDDP and inhibited hydrate formation in the release medium (PBS) containing NaCl (∼0.9 wt %) …”

Section: Resultsmentioning

confidence: 99%

“…The fast CDDP release from the hydrogels in vitro may be attributed to the enhanced solubility of CDDP, reduced substitution activity of Cl − ions in CDDP and inhibited hydrate formation in the release medium (PBS) containing NaCl (∼0.9 wt %). 48 3.4. In Vitro Cytotoxicities of Drug-Loaded Hydrogels against Osteosarcoma Saos-2 and MG-63 Cells.…”

Section: Synthesis and Characterization Of Plga−peg− Plga Triblockmentioning

confidence: 99%

See 1 more Smart Citation

Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment

Cheng

et al. 2015

ACS Appl. Mater. Interfaces

139

View full text Add to dashboard Cite

Localized cancer treatments with combination drugs have recently emerged as crucial approaches for effective inhibition of tumor growth and reoccurrence. In this study, we present a new strategy for the osteosarcoma treatment by localized co-delivery of multiple drugs, including doxorubicin (DOX), cisplatin (CDDP) and methotraxate (MTX), using thermosensitive PLGA-PEG-PLGA hydrogels. The release profiles of the drugs from the hydrogels were investigated in vitro. It was found that the multidrug coloaded hydrogels exhibited synergistic effects on cytotoxicity against osteosarcoma Saos-2 and MG-63 cells in vitro. After a single peritumoral injection of the drug-loaded hydrogels into nude mice bearing human osteosarcoma Saos-2 xenografts, the hydrogels coloaded with DOX, CDDP, and MTX displayed the highest tumor suppression efficacy in vivo for up to 16 days, as well as led to enhanced tumor apoptosis and increased regulation of the expressions of apoptosis-related genes. Moreover, the monitoring on the mice body change and the ex vivo histological analysis of the key organs indicated that the localized treatments caused less systemic toxicity and no obvious damage to the normal organs. Therefore, the approach of localized co-delivery of DOX, CDDP, and MTX by the thermosensitive hydrogels may be a promising approach for enhanced osteosarcoma treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Synthesis and Characterization Of Plga−peg− Plga Triblockmentioning

confidence: 99%

Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment

Cheng

et al. 2015

ACS Appl. Mater. Interfaces

139

View full text Add to dashboard Cite

show abstract

“…[ 38,39 ] Notably, the initial burst of CDDP from the hydrogels was more pronounced, likely due to the enhanced water‐solubility of CDDP in the PBS buffer containing sodium chloride (NaCl). [ 44 ] The sustainedly released DOX might play an important role for enhancing the CDDP‐sensitivity of A549/CDDP cells. [ 23,28 ]…”

Section: Resultsmentioning

confidence: 99%

Thermosensitive Polypeptide Hydrogels Co‐Loaded with Two Anti‐Tumor Agents to Reduce Multi‐Drug Resistance and Enhance Local Tumor Treatment

Quan

et al. 2020

Advanced Therapeutics

View full text Add to dashboard Cite

Localized tumor treatment with hydrogels co‐loaded with two or more drugs is an emerging approach offering superior anti‐tumor efficacy and reduced systemic toxicity. Nevertheless, the development of multi‐drug resistance (MDR) during sustained local treatment with hydrogel depots has not been studied. In this study, a strategy is developed for local tumor combination therapy using a polypeptide hydrogel co‐loaded with doxorubicin (DOX) and cisplatin (CDDP) for evaluation in both drug‐sensitive A549 and CDDP‐resistant A549 (A549/CDDP) tumor models. It is found that the combination of DOX and CDDP synergistically inhibits both A549 and A549/CDDP cells in vitro, accompanying increased inhibition of the expression of the MDR and anti‐apoptosis B‐cell lymphoma 2 (Bcl‐2) genes. After a single peritumoral injection into nude mice bearing A549 or A549/CDDP xenografts, the DOX/CDDP co‐loaded hydrogels exhibit remarkably high anti‐tumor efficiency, compared with a dual‐drug solution or single drug‐loaded hydrogels. The development of MDR genes in both tumor models is inhibited by the hydrogel‐based combination therapy. This study presents an efficient strategy for long‐acting treatment of both drug‐sensitive and drug‐resistant tumors.

show abstract

“…As shown in Figure A and C, only around 9.8% of CDDP in Gel-2 was released in phosphate buffer (PB, 10 mM) without NaCl during a period of 7 days. This result was likely caused by the combination effects of reduced solubility of CDDP in the absence of NaCl and the complexation between CDDP and the carboxyl groups. , …”

Section: Resultsmentioning

confidence: 99%

“…This result was likely caused by the combination effects of reduced solubility of CDDP in the absence of NaCl and the complexation between CDDP and the carboxyl groups. 60,61 Furthermore, the cytotoxicities of the blank hydrogel and drug-loaded hydrogel were evaluated against C26, HeLa and MCF-7 cell lines. As shown in Figure S2, these materials exhibited good biocompatibilities in vitro.…”

Section: Resultsmentioning

confidence: 99%

Injectable Thermosensitive Polypeptide-Based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy

Zhang

et al. 2017

Biomacromolecules

View full text Add to dashboard Cite

In this study, a type of novel thermosensitive polypeptide-based hydrogel with tunable gelation behavior through changing the content of carboxyl groups was developed for the purpose of improving the cisplatin (CDDP) release behavior and enhancing the localized antitumor efficiency. The introduction of carboxyl groups in methoxy-poly(ethylene glycol)-b-(poly(γ-ethyl-l-glutamate-co-l-glutamic acid) (mPEG-b-P(ELG-co-LG)) not only led to adjustable mechanical properties of the hydrogel but also significantly reduced the burst release of the drug through the complexation between the carboxyl groups of polypeptide and CDDP. Furthermore, both the good biocompatibility and the biodegradable properties of mPEG-b-P(ELG-co-LG) hydrogel were observed in vivo. Interestingly, the CDDP-complexed mPEG-b-P(ELG-co-LG) hydrogel exhibited significantly enhanced antitumor efficacy in vivo compared to the mPEG-b-PELG hydrogel loaded with CDDP without complexation, although a lower cytotoxicity and IC of the CDDP-complexed hydrogel was observed in vitro. Overall, the new type of injectable CDDP-complexed hydrogel may serve as an efficient platform for sustained CDDP delivery in localized tumor therapy.

show abstract

Cisplatin Suppository: Preparation, Release Characteristics and Clinical Evaluation.

Cited by 4 publications

References 0 publications

Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment

Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment

Thermosensitive Polypeptide Hydrogels Co‐Loaded with Two Anti‐Tumor Agents to Reduce Multi‐Drug Resistance and Enhance Local Tumor Treatment

Injectable Thermosensitive Polypeptide-Based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy

Contact Info

Product

Resources

About