Cisplatin, Interleukin-2, Interferon-α and Tamoxifen in Metastatic Melanoma. A Phase II Study

Naglieri, Emanuele; Procacci, A.; Galetta, Domenico; Abbate, Isabella; Dell'Erba, L; Colucci, Giuseppe

doi:10.1179/joc.1999.11.2.150

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…To overcome this intrinsic resistance of the established tumor, combination of immunotherapy and chemotherapy were investigated [52–54]. Even previous studies performed by Naglieri et al [53] and Zagozdzon et al [54] on the immuno-chemotherapy showed contradictory results, the combination in our case was positive. It might depend on the different assemblies of interleukin, cisplatin, and other anticancer factors or diversity of dosage.…”

Section: Results and Disscusionmentioning

confidence: 65%

Investigation of PEG-PLGA-PEG Nanoparticles-based Multipolyplexes for IL-18 Gene Delivery

Nie

Zhang

et al. 2011

J Biomater Appl

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Nanoparticles were formulated with biodegradable monomethoxy (poly ethylene glycol)-poly(lactide-co-glycolide)-monomethoxy (poly ethylene glycol) of three different proportional (PEG-PLGA-PEG, lactic acid: glycolic acid = 80/20, 70/30, 50/50) and the cytotoxicity of nanoparticle was characterized according to US Pharmacopoeia XXIII recommendations on various cell lines, including L929, Chang's hepatocytes, primary mouse myoblasts, osteoblasts, and renal vascular endothelial cells. mIL-18 gene was first condensed by polycationic peptide polylysine (PLL), and then encapsulated in the PEG-PLGA-PEG NPs as a novel multi-polyplex gene delivery system - Polymer-PLL-DNA. (PPDs) After lyopholization, the morphology, particle size, zeta potential, and the integrity of DNA in the NPs were investigated. The expression of mIL-18 gene on CT-26 cells in vitro were determined by western blot, while in vivo efficacy was evaluated by tumor inhibition rate, histological section, and survival curve in pulmonary metastasis of colon cancer in BALB/c mice model. Results showed that the cytotoxicity of blank nanoparticles was related to the degradation properties of the polymers with different compositions. The NPs with LA:GA = 70/30 (NPs-73) was optimal for intravenous injection due to its low cytotoxicity. Physicochemical properties of the PPDs were not changed during the lyopholization, while mIL-18 was successfully expressed in vitro. The anti-tumor efficacy in vivo of PPDs showed improvement especially combined with chemotherapy of cisplatin, and confirmed the promising application of the PPDs system, which compared with any single treatment.

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Section: Results and Disscusionmentioning

confidence: 65%

Investigation of PEG-PLGA-PEG Nanoparticles-based Multipolyplexes for IL-18 Gene Delivery

Nie

Zhang

et al. 2011

J Biomater Appl

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The Interferons

Edwards¹

2001

Dermatologic Clinics

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The interferons are a group of naturally occurring biologic response modifiers that exhibit antiviral, antiproliferative, differentiating, and immune-enhancing properties. This interesting group of compounds has been found to be effective for the treatment of condylomata acuminata, skin cancers, high-risk melanoma, hepatitis C, mycosis fungoides, and keloid scars. The advantages of these agents must be weighed against their toxicities, the number of treatments, and cost.

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Chemo-immunotherapy and chemo-adoptive immunotherapy of cancer

Gomez¹,

Hutchison²,

Kruse³

2001

Cancer Treatment Reviews

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Cisplatin, Interleukin-2, Interferon-α and Tamoxifen in Metastatic Melanoma. A Phase II Study

Abstract: Our results, unlike the good results of previous trials, are very poor. Therefore we do not recommend this combination for routine treatment of advanced melanoma.

Cited by 6 publications

References 10 publications

Investigation of PEG-PLGA-PEG Nanoparticles-based Multipolyplexes for IL-18 Gene Delivery

Investigation of PEG-PLGA-PEG Nanoparticles-based Multipolyplexes for IL-18 Gene Delivery

The Interferons

Chemo-immunotherapy and chemo-adoptive immunotherapy of cancer

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