Cisplatin Induces Up-Regulation of KAI1, a Metastasis Suppressor Gene, in MCF-7 Breast Cancer Cell Line

Abstract

97 ± 0.19 (p < 0.05), 2.96 ± 0.55 (p < 0.05), 9.06 ± 0.27 (p < 0.001) and 12.38 ± 0.88 (p < 0.01) in 10, 20, 50 and

Synthesis, structural characterization and cytotoxicity of nickel(II) complexes containing 3,3-dialkyl/aryl-1-benzoylthiourea ligands

“…The cell growth inhibition of complex 1 shows 40% at all concentrations (36, 18 and 12.1 lM), and 5 exhibits 40% cell inhibition at 40 and 60 lg/lL (16 and 10.3 lM). Complexes 2 and 6 showed no significant cell growth reduction at all concentrations after 48 h. Interestingly, complexes 3 and 4 were more potent than cisplatin against T47D cell line in low and high micro-molar concentrations when compared with already reported data[31,32]. For example, complex 3 showed IC50 $8.8 lM which is comparatively very low to the IC50 value of cisplatin (43.69 lM).…”

Auranofin, an Anti-Rheumatic Gold Compound, Modulates Apoptosis by Elevating the Intracellular Calcium Concentration ([Ca2+]i) in MCF-7 Breast Cancer Cells

“…Cytotoxicity of Auranofin for 72 h were tested in a panel of cancer cell-lines by Valentina Gandin and coworkers which reported an IC 50 of 0.23 μΜ (HL-60), 0.75 μΜ (A549), 0.98 μΜ (MCF-7), 0.34 μΜ (A375), 0.11 μΜ (HCT-15), 0.15 μΜ (HeLa) [ 16 ]. Auranofin appears to be 10 times more efficient in inducing cell death than cisplatin in this cell-line where an IC 50 of 43.7 μΜ was recently reported [ 17 ]. Auranofin proves to be more potent than cisplatin to induce cell death in this MCF-7 breast cancer cell line and therefore might be the better choice for treatment.…”

Quercetin can inhibit angiogenesis via the down regulation of MALAT1 and MIAT LncRNAs in human umbilical vein endothelial cells

“…This allowed us to increase the dynamic range resolution and make changes at the gene expressions. [ 24 ] The standard curves slopes were −3.36, −3.35, and −3.41 for MALAT1 , MIAT , and GAPDH , respectively. PCR efficiency was computed as 98.15% for MALAT1 , 98.60% for MIAT, and 96.33% for GAPDH [ Figure 3 ].…”