Cisplatin for cancer therapy and overcoming chemoresistance

Ranasinghe, Ranmali; Mathai, Michael L.; Zulli, Anthony

doi:10.1016/j.heliyon.2022.e10608

Cited by 36 publications

(21 citation statements)

References 206 publications

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“…Therefore, it is reasonable to speculate that PEI-Pt NCs can exhibit autofluorescence and then play a certain role in the localization of osteosarcoma cells. Third, oxidized platinum (corrosive platinum ions) easily binds to DNA under physiological conditions, causing DNA damage to kill cells, which is the most basic and common anticancer mechanism of platinum drugs. , Therefore, it is reasonable to speculate that PEI-Pt NCs can also exert the traditional platinum drug cell-killing mechanism to exert an anticancer effect in osteosarcoma. The above three points are reasonable conjectures based on previous studies, so this study conducted a series of experimental studies to confirm these expected properties of PEI-Pt NCs.…”

Section: Discussionmentioning

confidence: 99%

Multiproperty Polyethylenimine-Caged Platinum Nanoclusters Promote Apoptosis of Osteosarcoma Cells via Regulating the BAX-Bcl-2/Caspase-3/PARP Axis

Wang,

Zhang,

Huang

et al. 2023

Mol. Pharmaceutics

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Osteosarcoma, a prevalent primary bone cancer in children, exhibits a poor prognosis due to the high prevalence of drug resistance. The objective of this study was to investigate the potential of fluorescent ultrafine polyethylenimine-coated caged platinum nanoclusters (PEI-Pt NCs) as an antitumor agent in osteosarcoma. The primary focus of this study involved the utilization of osteosarcoma cells (U2-OS and MG-63) and normal control cells (hBMSC) as the primary subjects of investigation. The capacity of PEI-Pt NCs to enter osteosarcoma cells was observed through the implementation of confocal microscopy. The impact of PEI-Pt NCs on migration and proliferation was assessed through the utilization of various methodologies, including the CCK8 assay, K i-67 immunofluorescence, clone formation assay, transwell assay, and wound healing assay. Furthermore, the influence of PEI-Pt NCs on apoptosis and its underlying mechanism was explored through the implementation of flow cytometry and Western blotting techniques. The PEI-Pt NCs demonstrated the capability to enter osteosarcoma cells, including the nucleus, while also exhibiting fluorescent labeling properties. Furthermore, the PEI-Pt NCs effectively impeded the migration and proliferation of osteosarcoma cells. Additionally, the PEI-Pt NCs facilitated apoptosis by modulating the BAX-Bcl-2/Caspase 3/PARP axis. The novel nanomaterial PEI-Pt NCs possess diverse advantageous capabilities, including the ability to impede cell proliferation and migration, as well as the capacity to modulate the BAX-Bcl-2/Caspase 3/PARP axis, thereby promoting cell apoptosis. Consequently, this nanomaterial exhibits promising potential in addressing the issue of inadequate platinum-based treatment for osteosarcoma.

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Section: Discussionmentioning

confidence: 99%

Multiproperty Polyethylenimine-Caged Platinum Nanoclusters Promote Apoptosis of Osteosarcoma Cells via Regulating the BAX-Bcl-2/Caspase-3/PARP Axis

Wang,

Zhang,

Huang

et al. 2023

Mol. Pharmaceutics

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“…Based on a meta-analysis using ten studies (sample size = 1317), Atashi et al reported 33% cisplatinresistance [27]. Since cisplatin is the first-line systemic treatment for HNC, it then becomes important to overcome cisplatinresistance to improve prognosis [28].…”

Section: Head and Neck Cancersmentioning

confidence: 99%

“…Tumouroid culture model systems have been further developed using different methods, such as microcarriers [34], air-liquid interface (ALI) method [35,36], Microfluidic device, Organoid-On-A-Chip models [28,34], and organoids with bioreactors [34,37]. These methods are currently in a development stage, with a significant focus on the extracellular environment including vascular, neuronal, and immune system input.…”

Section: Future Outlookmentioning

confidence: 99%

Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges

et al. 2023

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Head and neck cancers (HNC) are the seventh most prevalent cancer type globally. Despite their common categorisation, HNCs are a heterogeneous group of malignancies arising in various anatomical sites within the head and neck region. These cancers exhibit different clinical and biological manifestations, and this heterogeneity also contributes to the high rates of treatment failure and mortality. To evaluate patients who will respond to a particular treatment, there is a need to develop in vitro model systems that replicate in vivo tumour status. Among the methods developed, patient-derived cancer organoids, also known as tumouroids, recapitulate in vivo tumour characteristics including tumour architecture. Tumouroids have been used for general disease modelling and genetic instability studies in pan-cancer research. However, a limited number of studies have thus far been conducted using tumouroid-based drug screening. Studies have concluded that tumouroids can play an essential role in bringing precision medicine for highly heterogenous cancer types such as HNC.

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“…Cisplatin ( cis -dichlorodiammineplatinum (II)) is an antineoplasic agent widely used in adults and children ( Ranasinghe et al, 2022 ). Upon entering the cell, it binds to DNA, creating platinum covalent adducts which damage DNA, triggering DNA-repair response, oxidative stress and subsequent apoptosis ( Riddell and Lippard, 2018 ; Gentilin et al, 2019 ).…”

Section: Cisplatin Ototoxicity In Zebrafishmentioning

confidence: 99%

Hair cell toxicology: With the help of a little fish

Barrallo-Gimeno

Llorens

2022

Front. Cell Dev. Biol.

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Hearing or balance loss are disabling conditions that have a serious impact in those suffering them, especially when they appear in children. Their ultimate cause is frequently the loss of function of mechanosensory hair cells in the inner ear. Hair cells can be damaged by environmental insults, like noise or chemical agents, known as ototoxins. Two of the most common ototoxins are life-saving medications: cisplatin against solid tumors, and aminoglycoside antibiotics to treat infections. However, due to their localization inside the temporal bone, hair cells are difficult to study in mammals. As an alternative animal model, zebrafish larvae have hair cells similar to those in mammals, some of which are located in a fish specific organ on the surface of the skin, the lateral line. This makes them easy to observe in vivo and readily accessible for ototoxins or otoprotective substances. These features have made possible advances in the study of the mechanisms mediating ototoxicity or identifying new potential ototoxins. Most importantly, the small size of the zebrafish larvae has allowed screening thousands of molecules searching for otoprotective agents in a scale that would be highly impractical in rodent models. The positive hits found can then start the long road to reach clinical settings to prevent hearing or balance loss.

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Cisplatin for cancer therapy and overcoming chemoresistance

Cited by 36 publications

References 206 publications

Multiproperty Polyethylenimine-Caged Platinum Nanoclusters Promote Apoptosis of Osteosarcoma Cells via Regulating the BAX-Bcl-2/Caspase-3/PARP Axis

Multiproperty Polyethylenimine-Caged Platinum Nanoclusters Promote Apoptosis of Osteosarcoma Cells via Regulating the BAX-Bcl-2/Caspase-3/PARP Axis

Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges

Hair cell toxicology: With the help of a little fish

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