1999
DOI: 10.1002/(sici)1097-0142(19990515)85:10<2226::aid-cncr18>3.0.co;2-x
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Cisplatin-based polychemotherapy reduces the natural cytotoxicity of peripheral blood mononuclear cells in patients with advanced ovarian carcinoma and their in vitro responsiveness to interleukin-12 incubation

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Cited by 9 publications
(6 citation statements)
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References 21 publications
(15 reference statements)
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“…The same group reported that cisplatin-based CT which included doxorubicin and cyclophosphomide led to a reduction of NK cell cytotoxic activity in postsurgical patients with advanced ovarian carcinoma. Notably, this effect was reversed when the patients were pretreated with amifostine [113]. For breast cancer patients at various stages, NK cells taken from those administered a variety of chemotherapeutic regimens manifested less cytotoxicity compared to patients on short dose regimens, or to patients on endocrine therapy [114].…”
Section: In Vitro and In Vivo Effects Of Ct Administration On Nk Cellsupporting
confidence: 91%
“…The same group reported that cisplatin-based CT which included doxorubicin and cyclophosphomide led to a reduction of NK cell cytotoxic activity in postsurgical patients with advanced ovarian carcinoma. Notably, this effect was reversed when the patients were pretreated with amifostine [113]. For breast cancer patients at various stages, NK cells taken from those administered a variety of chemotherapeutic regimens manifested less cytotoxicity compared to patients on short dose regimens, or to patients on endocrine therapy [114].…”
Section: In Vitro and In Vivo Effects Of Ct Administration On Nk Cellsupporting
confidence: 91%
“…This suggests a postexposure anticancer T-cell response, hampered by coinciding PD-L1 expression. High doses of cisplatin significantly reduced IFN-c production by T-cells in vitro [95], and reduced the cytotoxicity of NK cells in ovarian cancer patients [96]. Lower doses impaired T-cell function less significantly [95].…”
Section: Alkylating and Platinum-based Anticancer Agentsmentioning
confidence: 92%
“…Cytotoxic drug therapy has a negative effect on immune reactivity. Patients show a decrease in NK activity even after surgery (15,16). Results of immune monitoring suggest a significant progressive reduction in NK cell activity during combinedagent adjuvant chemotherapy, despite the relative stability of lymphocyte subsets.…”
Section: Discussionmentioning
confidence: 99%