Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-?B

Kato, Taiji; Duffey, Dianne C.; Ondrey, Frank G.; Dong, Gang; Chen, Zhong; Cook, John A.; Mitchell, James B.; Waes, Carter Van

doi:10.1002/1097-0347(200012)22:8<748::aid-hed2>3.0.co;2-6

Cited by 79 publications

(17 citation statements)

References 54 publications

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“…It has also been shown that the up-regulated expression of tumor-promoting cytokines IL-6, IL-8, and TNF-␣ in various cancers is the result of increased activation of NFB (46). In addition, it has also been shown that NFB expression is associated with the development of cancer stem cells related to chemoradiation resistance in several malignancies including head and neck, colon, and prostate cancers (47). Therefore, understanding the control of NFB activation pathways represents an important target in the area of cancer prevention and therapy.…”

Section: Discussionmentioning

confidence: 99%

p16 Protein and Gigaxonin Are Associated with the Ubiquitination of NFκB in Cisplatin-induced Senescence of Cancer Cells

Veena

Wilken

Zheng

et al. 2014

Journal of Biological Chemistry

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Background: Molecular mechanism of p16-mediated cellular senescence in cisplatin-treated cells is not known. Results: Cisplatin treatment leads to p16 nuclear transport and association with gigaxonin for the ubiquitination of NFB. Conclusion: A protein associated with neural diseases is involved in cisplatin-mediated cellular senescence. Significance: Nuclear expression of p16 and gigaxonin is a useful marker of cancer cell chemosensitivity.

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Section: Discussionmentioning

confidence: 99%

p16 Protein and Gigaxonin Are Associated with the Ubiquitination of NFκB in Cisplatin-induced Senescence of Cancer Cells

Veena

Wilken

Zheng

et al. 2014

Journal of Biological Chemistry

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“…Expression of the IkB super-repressor results in increased apoptosis in irradiated fibroblasts or ORL cancer cells [36][37][38]. NF-jB plays a role in the genesis and immortalization of NPC.…”

Section: Discussionmentioning

confidence: 99%

Association of nuclear factor κB expression with a poor outcome in nasopharyngeal carcinoma

et al. 2010

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The aim of this study was to determine the relationship between nuclear factor κB and the prognosis of patients with nasopharyngeal carcinoma. We used immunohistochemical studies to examine nuclear factor κB expression in 42 patients with nasopharyngeal carcinoma. The results showed that tumors positive for nuclear factor κB were associated with an increased relapse potential, poor disease-free survival, and reduced overall survival in nasopharyngeal carcinoma. Our study indicates that nuclear factor κB could be an independent molecular marker for predicting poor prognosis among patients with nasopharyngeal carcinoma. Understanding the biology of nuclear factor κB-mediated pathways may lead to the development of novel therapeutic strategies for nasopharyngeal carcinoma.

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“…80, 81 Moreover, NF-κB also has been reported to play a role in the development of resistance to chemotherapeutics in HNSCC. 82, 83 Several lines of evidence exist to indicate that NF-κB is involved in HNSCC metastasis. Nuclear NF-κB staining was detected in 52% of primary HNSCC tumors with positive nodes compared to only 23% of primary HNSCC tumors without positive nodes.…”

Section: Nuclear Factor-κbmentioning

confidence: 99%

Molecular Parameters of Head and Neck Cancer Metastasis

Bhave

Teknos

Pan

2011

Crit Rev Eukar Gene Expr

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Metastasis remains a major cause of mortality in patients with head and neck squamous cell carcinoma (HNSCC). HNSCC patients with metastatic disease have extremely poor prognosis with survival rate of less than a year. Metastasis is an intricate sequential process which requires a discrete population of tumor cells to possess the capacity to intravasate from the primary tumor into systemic circulation, survive in circulation, extravasate at a distant site, and proliferate in a foreign hostile environment. Literature has accumulated to provide mechanistic insight into several signal transduction pathways, receptor tyrosine kinases (RTKs), signal transducer and activator of transcription 3 (Stat3), Rho GTPases, protein kinase Cε (PKCε), and nuclear factor-κB (NF-κB), that are involved in mediating a metastatic tumor cell phenotype in HNSCC. Here we highlight accrued information regarding the key molecular parameters of HNSCC metastasis.

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Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-?B

Cited by 79 publications

References 54 publications

p16 Protein and Gigaxonin Are Associated with the Ubiquitination of NFκB in Cisplatin-induced Senescence of Cancer Cells

p16 Protein and Gigaxonin Are Associated with the Ubiquitination of NFκB in Cisplatin-induced Senescence of Cancer Cells

Association of nuclear factor κB expression with a poor outcome in nasopharyngeal carcinoma

Molecular Parameters of Head and Neck Cancer Metastasis

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