Cisplatin and doxorubicin dual-loaded mesoporous silica nanoparticles for controlled drug delivery

Li, Hanwen; Yu, Huijuan; Zhu, Caiying; Hu, Jianhua; Du, Minquan; Zhang, Fayong; Yang, Dong

doi:10.1039/c6ra17213j

Cited by 44 publications

(28 citation statements)

References 60 publications

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“…Dual/multi cargo loading related works recently seen in the literature [33,34,59], only focused on the utilization of mesoporous nanoparticles (the used MSN particles are mostly having gradient porosity in meso-scale but they do not have hierarchical porosity by definition). Hierarchically porous materials such as SiOC particles produced in the present work, were never used before and could perhaps be more functional in multi drug delivery therapies.…”

Section: Drug Releasementioning

confidence: 99%

“…For example, Song et al [59] reported dual delivery of fluorescein and rhodamine B (MW of 332.3 and 479 Da, respectively). Li et al [33] used silica nanoparticles for codelivery of doxorubicine (MW of 543.5 Da) and and cisplatin (300 Da). Fluorescein molecules are documented to be oblate ellipsoid with approximated volume of 0.4 nm 3 , other molecules with comparable MWs are expected to be in the similar size range [60].…”

Section: Drug Releasementioning

confidence: 99%

“…Aforementioned studies have typically attempted to develop a carrier system to load a single drug, however loading a single cargo may not suffice to achieve ideal therapeutic efficacy, as in the case for chemotherapeutic drugs. As known, for the treatment of metastatic cancers a resistance to single agent occurs, and it can be overcome by combination chemotherapy using multiple anticancer agents producing a synergetic effect [33]. While dual/multi cargo carrier related works recently have been reported in the literature [33][34][35], such works used mesoporous particles (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems

et al. 2018

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SiOC ceramics were fabricated by a simple technique to obtain high surface area (reaching 774 m 2 /g) hierarchical porosity. • Porous SiOC material were found to be biocompatible with less hemolysis than MCM-41. • The loading capacity and the release kinetics of cargo loaded SiOC were better than that of MCM-41. • It was demonstrated that hierarchical porosity ceramic can be used to carry different sized drug molecules. • The antimicrobial activity tests show that SiOC performs better than MCM-41 in improving bactericidal activity.

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Section: Drug Releasementioning

confidence: 99%

Section: Drug Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems

et al. 2018

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“…The nanoparticles depicted controlled in vitro release behaviour within 144 h. The confocal fluorescence microscopy (CFM) had confirmed the efficient delivery of CDDP and DOX against human cervical carcinoma cells. The nanoparticles exhibited higher cytotoxicity and synergistic effect against HeLa and A357 cells [103]. Dual-cisplatin and 6-mercaptopurine had been successfully loaded in MSNs.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

Farooq

Aquib

Farooq

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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2019) Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview, Artificial ABSTRACT Cisplatin cis-(diammine)dichloridoplatinum(II) (CDDP) is the first platinum-based complex approved by the food and drug administration (FDA) of the United States (US). Cisplatin is the first line chemotherapeutic agent used alone or combined with radiations or other anti-cancer agents for a broad range of cancers such as lung, head and neck. Aroplatin TM , Lipoplatin TM and SPI-077 are PEGylated liposomebased nano-formulations that are still under clinical trials. They have many limitations, for example, poor aqueous solubility, drug resistance and toxicities, which can be overcome by encapsulating the cisplatin in Nemours nanocarriers. The extensive literature from different electronic databases covers the different nano-delivery systems that are developed for cisplatin. This review critically emphasizes on the recent advancement, development, innovations and updated literature reported for different carrier systems for CDDP. ARTICLE HISTORY Current status of FDA-approved/under clinical trials CDDP nano-formulationsMany liposomal-based nano-formulations are at the stage of clinical trials. One of under clinical trials drugs, Lipoplatin (Regulon, Inc.), is liposome-based platinum formulation under Phase III clinical trials [11]. It contains a combination of cisplatin (9%) and lipids (91%(w/w)), including soy phosphatidylcholine (SPC-3), cholesterol, dipalmitoyl phosphatidyl glycerol (DPPG) and methoxy-PEG-distearoyl phosphatidyl

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“…Carboxylic acid-functionalized MSNs exhibit pH-and salt-induced Cis-Pt release. 25,27 Amino-functionalized MSNs show higher loading capacity than those functionalized with carboxylic acid, but retained and do not release a considerable amount of the loaded drug, possibly due to strong interactions between Cis-Pt and amino groups. 28 On the other hand, platinum can coordinate with the imidazole group, as reported for a series of cytotoxic platinum dichlorocomplexes 29,30 and imidazolefunctionalized SBA15 for solid-phase microextraction.…”

Section: Introductionmentioning

confidence: 99%

<p>Core–Shell Imidazoline–Functionalized Mesoporous Silica Superparamagnetic Hybrid Nanoparticles as a Potential Theranostic Agent for Controlled Delivery of Platinum(II) Compound</p>

Abedi¹,

Abolmaali²,

Abedanzadeh³

et al. 2020

IJN

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Introduction: As widely used chemotherapeutic agents, platinum compounds have several therapeutic challenges, such as drug resistance and adverse effects. Theranostic systems, macromolecular or colloidal therapeutics with companion diagnostics, not only address controlled drug delivery but also enable real-time monitoring of tumor sites. Methods: Synthesis of magnetic mesoporous silica nanoparticles (MMSNs) was performed for dual magnetic resonance imaging and drug delivery. MMSN surfaces were modified by imidazoline groups (MMSN-Imi) for cisplatin (Cis-Pt) conjugation via free N-termini to achieve wellcontrolled drug-release kinetics. Cis-Pt adsorption isotherms and drug-release profile at pH 5 and 7.4 were investigated using inductively coupled plasma atomic emission spectroscopy. Results: MMSN-Imi showed a specific surface area of 517.6 m 2 g −1 , mean pore diameter of 3.26 nm, and saturated magnetization of 53.63 emu/g. A relatively high r 2 /r 1 relaxivity value was obtained for MMSN-Imi. The nanoparticles provided high Cis-Pt loading with acceptable loading capacity (~30% w:w). Sustained release of Cis-Pt under acidic conditions led to specific inhibitory effects on the growth of human epithelial ovarian carcinoma cells, determined using MTT assays. Dual acridine orange-propidium iodide staining was investigated, confirming induction of apoptosis and necrotic cell death. Conclusion: MMSN-Imi exhibited potential for applications in cancer chemotherapy and combined imaging.

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Cisplatin and doxorubicin dual-loaded mesoporous silica nanoparticles for controlled drug delivery

Abstract: Multicomponent therapeutic platforms have been proposed to minimize dosage of each drug and reduce toxicity, leading to achieving a synergistic effect and maximizing therapeutic efficacy.

Cited by 44 publications

References 60 publications

Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems

Hierarchically porous polymer derived ceramics: A promising platform for multidrug delivery systems

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

<p>Core–Shell Imidazoline–Functionalized Mesoporous Silica Superparamagnetic Hybrid Nanoparticles as a Potential Theranostic Agent for Controlled Delivery of Platinum(II) Compound</p>

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