2021
DOI: 10.1016/j.bbamcr.2021.118954
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CISD2 maintains cellular homeostasis

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Cited by 49 publications
(51 citation statements)
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“…Aside from NAF-1(−) induced changes in mitochondria-ER MAM integrity (Figures 2 and 3), the multiple changes observed in INS-1E cells upon NAF-1 suppression recapitulate what we and others have observed in previous studies with non-endocrine cells in culture and with animal models of WFS-T2 (i.e., knockouts of NAF-1) [15,[60][61][62]. The novel finding of this work is therefore the establishment of a causative association between NAF-1 repression that leads to a mitochondrial labile iron rise and an increased mROS formation that triggers ferroptosis, and the impairment of β-cell insulin secretion.…”
Section: Discussionsupporting
confidence: 86%
“…Aside from NAF-1(−) induced changes in mitochondria-ER MAM integrity (Figures 2 and 3), the multiple changes observed in INS-1E cells upon NAF-1 suppression recapitulate what we and others have observed in previous studies with non-endocrine cells in culture and with animal models of WFS-T2 (i.e., knockouts of NAF-1) [15,[60][61][62]. The novel finding of this work is therefore the establishment of a causative association between NAF-1 repression that leads to a mitochondrial labile iron rise and an increased mROS formation that triggers ferroptosis, and the impairment of β-cell insulin secretion.…”
Section: Discussionsupporting
confidence: 86%
“…In addition, one of our previous studies revealed that Cisd2 regulates calcium homeostasis and the mitochondrial function [ 11 ]. In this study, we carried out quantification of the proteins involved in these biological processes in the liver.…”
Section: Resultsmentioning
confidence: 99%
“…Among these antioxidant enzymes, two of them, namely Glrx and Prdx3, were found to be downregulated in the 26-mo Cisd2TG mice compared to the 26-mo WT mice (Figure 5C). In addition, one of our previous studies revealed that Cisd2 regulates calcium homeostasis and the mitochondrial function [11]. In this study, we carried out quantification of the proteins involved in these biological processes in the liver.…”
Section: Cisd2 Modulates the Redox Status Calcium Homeostasis And Mitochondrial Respirationmentioning
confidence: 98%
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“…C isd2 is an evolutionally conserved gene that plays an essential role in mediating mammalian lifespan [ 14 ]. The Cisd2 protein is mainly located in the mitochondrial outer membrane, the endoplasmic reticulum (ER), and the mitochondria-associated membranes (MAMs).…”
Section: Introductionmentioning
confidence: 99%