Cisapride in the control of symptoms in infants with gastroesophageal reflux: A randomized, double-blind, placebo-controlled trial

Cohen, Richard. D.; O’Loughlin, Edward; Davidson, Geoffrey P.; Moore, David; Lawrence, Diana M.

doi:10.1016/s0022-3476(99)70451-8

Cited by 49 publications

(63 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cisaprid juga dapat membantu menyembuhkan esofagitis. 5,10,30 Tidak seperti metoklopramid, cisaprid memberikan efek samping serius yang sangat kecil. Beberapa keluhan pernah disampaikan oleh pasien yang mendapat cisaprid, antara lain kram perut ringan, diare atau konstipasi.…”

Section: Prokinetikunclassified

Esofagitis Refluks Pada Anak

Hegar¹,

Mulyani²

2016

View full text Add to dashboard Cite

Esofagitis refluks adalah proses inflamasi pada esofagus akibat refluks gastroesofagus. Toksisitas isi refluks, frekuensi, durasi episode refluks, dan resistensi esofagus terhadap isi refluks merupakan faktor yang berperan terhadap kejadian esofagitis. Gejala klinis esofagitis refluks tidak spesifik. Pada bayi sering terlihat muntah disertai gejala klinis iritabel, tidur tidak nyaman, menolak makan, dan gagal tumbuh, sedangkan pada anak yang lebih besar didapatkan keluhan heartburn dan nyeri epigastrium. Esofagitis tersebar secara 'patchy' dan tidak merata sehingga ketelitian pemeriksaan sangat diperlukan. Secara makroskopis mukosa esofagus dapat terlihat hiperemis, erosi, atau ulkus, sedangkan pada patologi anatomi terlihat gambaran hiperplasia membran basal dengan papila yang memanjang. Antagonis reseptor H2 dan inhibitor pompa proton (IPP) telah digunakan secara luas untuk terapi esofagitis. Efek jangka pendek, jangka panjang, dan pencegahan relaps obat-obat tersebut memperlihatkan hasil yang memuaskan, walaupun beberapa data menunjukkan keunggulan IPP dibanding antagonis reseptor H2. Sari Pediatri, Vol. 8, No. 1, Juni 2006: 43 -53 E sofagitis refluks merupakan proses inflamasi epitel esofagus yang dapat disebabkan oleh berbagai faktor. Pada anak, esofagitis dapat terjadi akibat refluks gastroesofagus (RGE), infeksi (bakteri, virus dan jamur), atau bahan korosif. Esofagitis akibat RGE dikenal sebagai esofagitis refluks, merupakan bentuk penyakit refluks gastroesofagus (PRGE) dan penyebab esofagitis tersering pada anak. Kata kunci: refluks gastroesofagus, esofagitis, antagonis reseptor H2, inhibitor pompa propton 1,2Esofagitis refluks melibatkan berbagai proses yang mengakibatkan tidak berfungsinya mekanisme yang mencegah RGE dan mekanisme yang membersihkan esofagus dari bahan toksik.2 Toksisitas isi refluks (seperti asam, pepsin, empedu), frekuensi dan durasi episode refluks, serta resistensi esofagus terhadap isi refluks merupakan faktor yang berperan terhadap kejadian esofagitis. [3][4][5] Refluks gastroesofagus terjadi akibat aliran balik isi lambung ke dalam esofagus yang terjadi secara involunter. Keadaan ini merupakan fenomena fisiologis pada bayi yang bermanifestasi klinis sebagai regurgitasi. 4 Diperlukan pemeriksaan penunjang untuk membuktikan adanya RGE dan kerusakan mukosa esofagus akibat RGE.Pada beberapa individu, esofagitis refluks dapat merupakan suatu keadaan yang dialami seumur hidup dan dimulai sejak masa anak. Oleh karena itu, diagnosis dini dan terapi yang tepat pada masa anak sangat diperlukan untuk menghasilkan kondisi dan kualitas hidup yang lebih baik pada masa remaja dan dewasa.

show abstract

Section: Prokinetikunclassified

Esofagitis Refluks Pada Anak

Hegar¹,

Mulyani²

2016

View full text Add to dashboard Cite

show abstract

“…However, more recently the 2010 Cochrane Review did not show any difference in symptom improvement or weight gain when cisapride is compared to placebo [ 61 ] . Nine studies comparing cisapride with placebo or no treatment, that met inclusion criteria, were included in the meta-analysis [62][63][64][65][66][67][68][69] . The authors reviewed fi ve studies comparing results of esophageal pH probe in patients being treated with cisapride vs. placebo and while there was improvement in the re fl ux index, there was no signi fi cant improvement in the number of re fl ux episodes and episodes lasting longer than 5 min.…”

Section: -Hydroxytryptamine-4 Receptor Agonists Cisapridementioning

confidence: 99%

“…The authors reviewed fi ve studies comparing results of esophageal pH probe in patients being treated with cisapride vs. placebo and while there was improvement in the re fl ux index, there was no signi fi cant improvement in the number of re fl ux episodes and episodes lasting longer than 5 min. Histologic examination of the esophagus was performed in three studies and in 2 ( n − 6, n = 20) studies there was no statistical difference between cisapride and placebo [ 63,67 ] , however 1 study ( n = 17) did have histologic improvement from baseline. Further large-scale studies are needed to assess the utility of cisapride for GERD, though due to limited access, it is unlikely this information will be obtained.…”

Section: -Hydroxytryptamine-4 Receptor Agonists Cisapridementioning

confidence: 99%

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Har

Croffie

2012

Pediatric Neurogastroenterology

View full text Add to dashboard Cite

“…Several studies have shown that cisapride treatment over a four-week period can decrease the symptoms of regurgitation and vomiting in infants and children with reflux. [38][39][40][41] Other studies have shown that cisapride can improve esophageal histopathology and pulmonary function in patients with reflux esophagitis and respiratory complications. 38,39 Overall, studies have shown only marginal effectiveness of cisapride in the treatment of GERD in children.…”

Section: Prokinetic Therapymentioning

confidence: 99%

Clinical Management of Infants and Children with Gastroesophageal Reflux Disease

Whitworth¹,

Christensen

2004

The Journal of Pediatric Pharmacology and Therapeutics

View full text Add to dashboard Cite

Gastroesophageal reflux refers to the passage of gastric contents including food, acid, and digestive enzymes up into the esophagus. Reflux is most commonly recognized in infants when it is associated with regurgitation, known as “spitting up,” and it is usually a self-limited, benign process that has little or no effect on normal weight gain or development. Adults and adolescents may also have reflux, which is usually either asymptomatic or recognized as dyspepsia or “heartburn.” Gastroesophageal reflux disease (GERD) is defined as symptoms or complications that result from reflux. Most evidence suggests the mechanism of reflux is due to transient relaxations of the lower esophageal sphincter at inappropriate times. The diagnosis of suspected GERD in infants and children depends on the age and the presenting symptoms. A thorough history, physical examination, and growth charts are sufficient for the evaluation and diagnosis of GERD in most infants with recurrent vomiting or children with regurgitation and heartburn. Additional evaluation may include an upper gastrointestinal series, esophageal pH monitoring, or endoscopy. The goals of GERD management are eliminating symptoms, healing esophagitis, preventing complications, promoting normal weight gain and growth, and maintaining remission. Therapeutic options include lifestyle changes, pharmacologic therapy, and anti-reflux surgery. Currently available pharmacologic agents for the treatment of GERD include antacids, mucosal protectants, prokinetic agents, and acid suppressants.

show abstract

Cisapride in the control of symptoms in infants with gastroesophageal reflux: A randomized, double-blind, placebo-controlled trial

Cited by 49 publications

References 11 publications

Esofagitis Refluks Pada Anak

Esofagitis Refluks Pada Anak

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

Clinical Management of Infants and Children with Gastroesophageal Reflux Disease

Contact Info

Product

Resources

About