Abstract:Cis–regulatory elements (CRE) are critical for coordinating gene expression programs that dictate cell–specific differentiation and homeostasis. Recently developed self–transcribing active regulatory region sequencing (STARR–Seq) has allowed for genome-wide annotation of functional CREs. Despite this, STARR–Seq assays are only employed in cell lines, in part, due to difficulties in delivering reporter constructs. Herein, we implemented and validated a STARR–Seq–based screen in human CD4+ T cells using a non–in… Show more
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