Cis-platinum and 5-fluorouracil as induction therapy for advanced head and neck cancer

Weaver, Arthur; Flemming, Susan; Kish, Julie A.; VandenBerg, Henry J.; Jacob, John; Crissman, John D.; Al‐Sarraf, Muhyi

doi:10.1016/0002-9610(82)90419-6

Cited by 97 publications

(16 citation statements)

References 7 publications

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“…These results are comparable to those reported by Weaver et al 35 who observed no histologic evidence of tumor in 9 of 13 CR patients who underwent surgical resection after induction therapy with Cis-DDP and 5-fluorouracil. The significance of these pathologic findings relative to local control of disease or to survival is not clear from the data in the present study, or from that reported by Weaver and c o -w o r k e r~.~~,~~ These preliminary results are very encouraging, however, and indicate that the present regimen should be further evaluated.…”

Section: Discussionsupporting

confidence: 94%

Preoperative simultaneously administered cis‐platinum plus radiation therapy for advanced squamous cell carcinoma of the head and neck

et al. 1986

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Synchronously administered cis-platinum (cis-DDP) and radiation therapy have been used to treat unresectable squamous cell carcinomas of the head and neck. The purpose of this study was to evaluate the efficacy and tolerance of preoperative adjuvant cis-DDP plus radiation therapy in operable stage III and IV head and neck cancers. Radiation therapy (4,500 rad) was delivered in 180-rad daily fractions. Cis-DDP (20 mg/M2) was given before radiotherapy on days 1-4 and 21-24. Eighteen patients began therapy; 16 completed the combined regimen. Toxicity included stomatitis and WBC below 2,500/mm3. One patient died from therapy of a cerebrovascular accident. Sixteen patients (89%) achieved a complete or partial response to therapy. Complete responses were observed in 13 of 18 primary tumors (72%), and in all three patients with cervical lymphadenopathy. Complete responses were noted for lesions of the nasopharynx, oral cavity, pharynx, hypopharynx, and larynx, for all histologic grades of squamous cell carcinoma. Twelve patients underwent curative surgery. Site-related morbidity occurred in two patients (15%) and a third patient developed postoperative pneumonia. Five of 10 resected primary tumors with preoperative complete responses were pathologically negative for tumor. Concurrent bolus cis-DDP and radiation therapy are well-tolerated and result in impressive tumor reduction. Morbidity after subsequent curative surgery is low, and histologic complete responses are frequent.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 94%

Preoperative simultaneously administered cis‐platinum plus radiation therapy for advanced squamous cell carcinoma of the head and neck

et al. 1986

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“…Less than 30% of the patients survive 5 years. With the introduc tion of cisplatinum as an active agent for squamous cell cancer of the upper aerodigestive systems, high overall response rates were observed when cis-platinum combinations were used [1], In addition, cis-platinum was found to be able to potentiate the action of 5-fluorouracil [2]. Of more importance seems to be the biochemical interaction of 5-fluorouracil and folinic acid.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Chemo-Radiotherapy with 5-FU/Folinic Acid/cis-Platinum and Accelerated Split-Course Radiation in Advanced Head and Neck Cancer

Hartenstein

Wendt²,

Kastenbauer³

et al. 1989

Oncol Res Treat

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In a clinical phase-II trial, 62 previously untreated patients suffering from unresectable stage III (4 patients) and IV (56 patients) squamous cell carcinoma of the head and neck were treated with a simultaneous chemoradiotherapy consisting of a 5-fluorouracil/folinic acid/cis-platinum combination and of an accelerated split-course radiotherapy. As results, 3 patients died from tumor arrosion bleeding during the treatment. The median follow-up time of the surviving patients is 27 + months (range 18–44 months). Forty-eight out of 62 patients (77%) achieved complete remission, and 11/62 patients (18%) partial remission. Presently, 32 patients (52%) are without evidence of disease. The actuarial 3-year overall survival rate (Kaplan-Meier method) out of 62 patients is 53%. The actuarial disease-free survival and local tumor control rates at 3 years are 58% and 72%. Toxicity on oral mucosa was severe but tolerable, bone marrow depression was marked but not life-threatening. In conclusion, this combined simultaneous modality approach is highly effective in locally advanced head and neck cancer. It appears to provide superior survival and local control rates as compared to conventional radiotherapy or sequential chemoradiotherapy.

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“…In the 1980s, high objective tumor response rates in HNSCC were reported when cisplatin was paired with 5-fluorouracil (5-FU), a pyrimidine antagonist that inhibits thymidylate synthase [8,9]. As such, the regimen of high-dose cisplatin plus infusional 5-FU (PF) emerged as the preferred induction chemotherapy regimen for further study.…”

Section: Induction Chemotherapy Studies Prior To Taxane Eramentioning

confidence: 99%

Induction chemotherapy in the management of head and neck cancer

Fury

Shah

2010

Journal of Surgical Oncology

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The strategy of induction chemotherapy prior to planned definitive local therapy for head and neck squamous cell carcinoma has been studied for over 30 years, and appears to have a role in select clinical situations. Here we review landmark studies regarding induction chemotherapy, both in the pre-taxane era and in the current taxane era, and we address some of the unresolved questions regarding the role of induction chemotherapy in head and neck cancer.

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Cis-platinum and 5-fluorouracil as induction therapy for advanced head and neck cancer

Cited by 97 publications

References 7 publications

Preoperative simultaneously administered cis‐platinum plus radiation therapy for advanced squamous cell carcinoma of the head and neck

Preoperative simultaneously administered cis‐platinum plus radiation therapy for advanced squamous cell carcinoma of the head and neck

Simultaneous Chemo-Radiotherapy with 5-FU/Folinic Acid/cis-Platinum and Accelerated Split-Course Radiation in Advanced Head and Neck Cancer

Induction chemotherapy in the management of head and neck cancer

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