Cis- and trans-splicing of group II introns in plant mitochondria

Bonen, Linda

doi:10.1016/j.mito.2007.09.005

Cited by 213 publications

(242 citation statements)

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“…Introns are rather common in land plant mitochondrial genomes, with a total of 23 in Arabidopsis, 25 in Physcomitrella spp., and 32 in Marchantia polymorpha (for review, see Bonen, 2008). Although the mitochondrial genomes of Physcomitrella spp.…”

Section: Discussionmentioning

confidence: 99%

“…Although the mitochondrial genomes of Physcomitrella spp. and M. polymorpha also contain several group I introns, the vast majority of the introns in flowering plants (with the exception of the cox1 intron in some species) belong to group II, with 23 in Arabidopsis and rice (Oryza sativa; Bonen, 2008). These introns seem to have lost their self-splicing ability, thus necessitating the help of maturases such as the nuclearly encoded nMAT1, nMAT2, nMAT3, and nMAT4 and possibly the mitochondrial MatR, whose function is still elusive (Keren et al, 2009(Keren et al, , 2012Brown et al, 2014;Cohen et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…at least 140 million years ago; Malek and Knoop, 1998). The expression of the nad genes involves a combination of cis-and trans-splicing events that remove group II introns from the transcripts (Bonen, 2008). Several RNA-binding proteins are known to be involved in mitochondrial splicing events in nad transcripts: ORGANELLE TRANSCRIPT PROCESS-ING43 (OTP43; trans-splicing of nad1 intron 1; Falcon de Longevialle et al, 2007), ABSCISIC ACID OVERLY SENSITIVE5 (cis-splicing of nad2 intron 3; Liu et al, 2010), RCC1/UV-B RESISTANCE8/GUANINE NUCLEOTIDE EXCHANGE FACTOR3 (RUG3; (trans-splicing of nad2 intron 2 and cis-splicing of intron 3; Kühn et al, 2011), NUCLEAR MALE STERILE1 (cis-splicing of nad4 intron 1; Brangeon et al, 2000), BUTHIONINE SULFOMIXINE-INSENSITIVE ROOTS6 (BIR6; cis-splicing of nad7 intron 1; Koprivova et al, 2010), and other less-specific factors such as PUTATIVE MITOCHONDRIAL RNA HELI-CASE2 (PMH2; Köhler et al, 2010), maturases (nMAT1, nMAT2, and nMAT4; Keren et al, 2009Keren et al, , 2012Brown et al, 2014;Cohen et al, 2014), and the MITOCHONDRIAL CHLOROPLAST RNA SPLICING ASSOCIATED FACTORlike SPLICING FACTOR1 (mCSF1; Zmudjak et al, 2013) affecting numerous introns.…”

mentioning

confidence: 99%

“…The nad5 mRNA is composed of five exons, derived from three transcription units (Knoop et al, 1991;Pereira de Souza et al, 1991;Bonen, 2008;Elina and Brown, 2010). Assembly of the mRNA requires two cis-splicing and two trans-splicing events.…”

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confidence: 99%

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The Pentatricopeptide Repeat Proteins TANG2 and ORGANELLE TRANSCRIPT PROCESSING439 Are Involved in the Splicing of the Multipartite nad5 Transcript Encoding a Subunit of Mitochondrial Complex I

Francs‐Small

Longevialle²,

Li³

et al. 2014

Plant Physiol.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Pentatricopeptide Repeat Proteins TANG2 and ORGANELLE TRANSCRIPT PROCESSING439 Are Involved in the Splicing of the Multipartite nad5 Transcript Encoding a Subunit of Mitochondrial Complex I

Francs‐Small

Longevialle²,

Li³

et al. 2014

Plant Physiol.

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“…A list of published sequences of mitochondrial subgroup IIB1 members, which contains the 10 organelle group II introns we found to possess additional nucleotides at their very 59 extremity, is provided in Table 1 (several subgroup IIB1 members from land plants other than Marchantia are missing from this list; they were excluded from our analyses because of the likelihood of ½partly undocumented editing of intron nucleotides prior to splicing) (see Bonen 2008).…”

Section: Distribution Of 59-terminal Inserts In Mitochondrial Subgroumentioning

confidence: 99%

Recurrent insertion of 5′-terminal nucleotides and loss of the branchpoint motif in lineages of group II introns inserted in mitochondrial preribosomal RNAs

Costa²,

Bassi³

et al. 2011

RNA

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A survey of sequence databases revealed 10 instances of subgroup IIB1 mitochondrial ribosomal introns with 1 to 33 additional nucleotides inserted between the 59 exon and the consensus sequence at the intron 59 end. These 10 introns depart further from the IIB1 consensus in their predicted domain VI structure: In contrast to its basal helix and distal GNRA terminal loop, the middle part of domain VI is highly variable and lacks the bulging A that serves as the branchpoint in lariat formation. In vitro experiments using two closely related IIB1 members inserted at the same ribosomal RNA site in the basidiomycete fungi Grifola frondosa and Pycnoporellus fulgens revealed that both ribozymes are capable of efficient self-splicing. However, whereas the Grifola intron was excised predominantly as a lariat, the Pycnoporellus intron, which possesses six additional nucleotides at the 59 end, yielded only linear products, consistent with its predicted domain VI structure. Strikingly, all of the introns with 59 terminal insertions lack the EBS2 exon-binding site. Moreover, several of them are part of the small subset of group II introns that encode potentially functional homing endonucleases of the LAGLIDADG family rather than reverse transcriptases. Such coincidences suggest causal relationships between the shift to DNA-based mobility, the loss of one of the two ribozyme sites for binding the 59 exon, and the exclusive use of hydrolysis to initiate splicing.

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Mitochondrial Genome Evolution

Bernt

Machné²,

Sahyoun

et al. 2013

Encyclopedia of Life Sciences

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Mitochondria are membrane‐enclosed organelles present in most eukaryotic cells that generate most of the cell's adenosine triphosphate (ATP) supply. Derived from a proteobacterial ancestor, mitochondria harbour their own, drastically reduced genome. Starting from a prokaryote‐like ancestral state encoding a complete ribosomal ribonucleic acid (rRNA) operon, a complete set of transfer RNAs (tRNAs) required for translation, and key enzymes of the respiratory chain as well as some ribosomal proteins, the mitogenome has been dramatically restructured and further reduced in many of the eukaryotic lineages. The loss and transfer to the nucleus of mitochondrial genes is a common trend in most phyla, in particular in Metazoa and Alveolata. In extreme, phylogenetically dispersed cases, often associated with parasitic or anaerobic life styles, mitochondria have been transformed to the so‐called mitosomes or hydrogenosomes devoid of their own genetic material. Ancestrally a single circular deoxyribonucleic acid (DNA) , mitogenomes have evolved to complex, fragmented architectures in particular in Euglenozoa. Key Concepts: Mitochondria have an endosymbiotic origin deriving from a proteobacterial ancestor. Various evolutionary mechanisms operate on mitochondrial genomes. Mitochondrial genomes have developed very diverse properties during eukaryote evolution. Mitogenomic gene content declines in most eukaryotic lineages by horizontal transfer to the nuclear genome. Complex idiosyncratic genome organisations have independently evolved in several eukaryotic phyla.

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Cis- and trans-splicing of group II introns in plant mitochondria

Cited by 213 publications

References 79 publications

The Pentatricopeptide Repeat Proteins TANG2 and ORGANELLE TRANSCRIPT PROCESSING439 Are Involved in the Splicing of the Multipartite nad5 Transcript Encoding a Subunit of Mitochondrial Complex I

The Pentatricopeptide Repeat Proteins TANG2 and ORGANELLE TRANSCRIPT PROCESSING439 Are Involved in the Splicing of the Multipartite nad5 Transcript Encoding a Subunit of Mitochondrial Complex I

Recurrent insertion of 5′-terminal nucleotides and loss of the branchpoint motif in lineages of group II introns inserted in mitochondrial preribosomal RNAs

Mitochondrial Genome Evolution

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