Cirsimaritin, a lung squamous carcinoma cells (NCIH-520) proliferation inhibitor

Pathak, Gauri; Singh, Shilpi; Kumari, Priyanka; Raza, Waseem; Hussain, Yusuf; Meena, Abha

doi:10.1080/07391102.2020.1763198

Cited by 21 publications

(17 citation statements)

References 61 publications

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“…A sesquiterpene lactone known as judaicin exhibited a cardio-tonic effect slightly better than digoxin [ 23 ]. Another compound that was later identified as cirsimaritin demonstrated antioxidant, anticancer, anti-inflammatory, antimicrobial, antagonistic, antidiabetic, neurological, cardiovascular, and hepatoprotective activities [ 24 , 25 , 26 ]. Both apigenin and quercetin displayed selective cytotoxic activity against many types of cancer cell lines with low or no toxicity to normal cells [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

et al. 2021

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Artemisia judaica L. (Family: Asteraceae) exhibited antioxidant, anti-inflammatory, and antiapoptotic effects. The in vitro cytotoxic activity of A. judaica ethanolic extract was screened against a panel of cancer cell lines. The results revealed its cytotoxic activity against a lung cancer (A549) cell line with a promising IC50 of 14.2 μg/mL compared to doxorubicin as a standard. This was confirmed through the downregulation of antiapoptotic genes, the upregulation of proapoptotic genes, and the cell cycle arrest at the G2/M phase. Further in vivo study showed that a solid tumor mass was significantly reduced, with a tumor inhibition ratio of 54% relative to doxorubicin therapy in a Xenograft model. From a chemical point of view, various classes of natural products have been identified by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS). The docking study of the detected metabolites approved their cytotoxic activity through their virtual binding affinity towards the cyclin-dependent kinase 2 (CDK-2) and epidermal growth factor receptor (EGFR) active sites. Finally, A. judaica is a fruitful source of polyphenols that are well-known for their antioxidant and cytotoxic activities. As such, the previously reported polyphenols with anti-lung cancer activity were quantified by high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD). Rutin, quercetin, kaempferol, and apigenin were detected at concentrations of 6 mg/gm, 0.4 mg/gm, 0.36 mg/gm, and 3.9 mg/gm of plant dry extract, respectively. It is worth noting that kaempferol and rutin are reported for the first time. Herein, A. judaica L. may serve as an adjuvant therapy or a promising source of leading structures in drug discovery for lung cancer treatment.

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Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

et al. 2021

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“…Interesting data have been collected on cirsimaritin, a dimethoxy flavone present in some plants. This molecule exhibits potent antimicrobial, antioxidant, and antispasmodic activities and also inhibits cyclooxygenase-1 (COX-1) [ 55 ]. Furthermore, it appears to block inflammatory action by inhibiting the expression of interleukin-6 (IL-6) and the activity of tumour necrosis factor-α (TNF-α) in cultures of LPS-stimulated macrophages [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice

et al. 2021

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Gynostemma pentaphyllum (var. Ginpent) (GP) is a variety of Cucurbit with anti-inflammatory and antioxidant effects in patients. In this manuscript, the main components present in the dry extract of GP have been identified using Ultra High Performance Liquid Chromatography quadrupole-time-of-flight mass spectrometry (UHPLC/Q-TOF-MS). In addition, the anti-inflammatory action of GP was evaluated in animal models with acute peripheral inflammation and motor alteration induced by lipopolysaccharide. The results showed that GP dry extract is rich in secondary metabolites with potential antioxidant and anti-inflammatory properties. We found that the treatment with GP induced a recovery of motor function measured with the rotarod test and pole test, and a reduction in inflammatory cytokines such as interleukin-1β and interleukin-6 measured with the ELISA test. The data collected in this study on the effects of GP in in vivo models may help integrate the therapeutic strategies of inflammatory-based disorders.

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“…Cirsimaritin also has anti-diabetes effects; cirsimaritin has been reported to reduce caspase-8 and 3 activities and increase B-cell lymphoma 2 (BCL-2) expression [36]. Cirsimaritin exerts anti-lung cancer effects on NCIH-520 cells by inhibiting proliferation compared to other cell lines and increasing the levels of apoptosis and ROS [37]. Cirsimaritin can also suppress influenza A virus replication by suppressing the NF-κB/p65, c-Jun N-terminal kinase (JNK), and p38 signaling pathways but does not change viral attachment and release.…”

Section: Cirsimarin and Cirsimaritinmentioning

confidence: 99%

Therapeutic Single Compounds for Osteoarthritis Treatment

et al. 2021

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Osteoarthritis (OA) is an age-related degenerative disease for which an effective disease-modifying therapy is not available. Natural compounds derived from plants have been traditionally used in the clinic to treat OA. Over the years, many studies have explored the treatment of OA using natural extracts. Although various active natural extracts with broad application prospects have been discovered, single compounds are more important for clinical trials than total natural extracts. Moreover, although natural extracts exhibit minimal safety issues, the cytotoxicity and function of all single compounds in a total extract remain unclear. Therefore, understanding single compounds with the ability to inhibit catabolic factor expression is essential for developing therapeutic agents for OA. This review describes effective single compounds recently obtained from natural extracts and the possibility of developing therapeutic agents against OA using these compounds.

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Cirsimaritin, a lung squamous carcinoma cells (NCIH-520) proliferation inhibitor

Cited by 21 publications

References 61 publications

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

In Vitro and In Vivo Studies of Anti-Lung Cancer Activity of Artemesia judaica L. Crude Extract Combined with LC-MS/MS Metabolic Profiling, Docking Simulation and HPLC-DAD Quantification

Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice

Therapeutic Single Compounds for Osteoarthritis Treatment

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