CiRS-7/CDR1as; An oncogenic circular RNA as a potential cancer biomarker

Rahmati, Yazdan; Asemani, Yahya; Aghamiri, Seyed Mahmoud Reza; Ezzatifar, Fatemeh; Najafi, Sajad

doi:10.1016/j.prp.2021.153639

Cited by 31 publications

(17 citation statements)

References 77 publications

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“…Since the discovery of the relevance of circRNAs in regulating miRNA activity, several computational tools have been developed to help identify these molecules and to predict their potential interactions [ 48 ]. In parallel, the growing evidence surrounding miRNA sponges has motivated the development of several tools that are dedicated to identifying competing interactions between these different types of molecules [ 49 ].…”

Section: The Cerna Hypothesis—a Transcriptome Wide Intrinsic Regulato...mentioning

confidence: 99%

Network Approaches to Study Endogenous RNA Competition and Its Impact on Tissue-Specific microRNA Functions

Marques

Gama‐Carvalho

2022

Biomolecules

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microRNAs are small non-coding RNAs that play a key role in regulating gene expression. These molecules exert their function through sequence complementarity with microRNA responsive elements and are typically located in the 3′ untranslated region of mRNAs, negatively regulating expression. Even though the relevant role of miRNA-dependent regulation is broadly recognized, the principles governing their ability to lead to specific functional outcomes in distinct cell types are still not well understood. In recent years, an intriguing hypothesis proposed that miRNA-responsive elements act as communication links between different RNA species, making the investigation of microRNA function even more complex than previously thought. The competing endogenous RNA hypothesis suggests the presence of a new level of regulation, whereby a specific RNA transcript can indirectly influence the abundance of other transcripts by limiting the availability of a common miRNA, acting as a “molecular sponge”. Since this idea has been proposed, several studies have tried to pinpoint the interaction networks that have been established between different RNA species and whether they contribute to normal cell function and disease. The focus of this review is to highlight recent developments and achievements made towards the process of characterizing competing endogenous RNA networks and their role in cellular function.

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Section: The Cerna Hypothesis—a Transcriptome Wide Intrinsic Regulato...mentioning

confidence: 99%

Network Approaches to Study Endogenous RNA Competition and Its Impact on Tissue-Specific microRNA Functions

Marques

Gama‐Carvalho

2022

Biomolecules

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“…Many circRNAs that are highly expressed in blood have relatively low expression of their corresponding linear RNAs ( Rahmati et al, 2021 ; Xiao et al, 2021 ). The unique functions and properties of circRNAs make them of great clinical potential in life sciences and medicine ( Gu et al, 2021 ; Yi et al, 2021 ).…”

Section: Roles and Significance Of Circrnas In Pediatric Malignant Solid Tumorsmentioning

confidence: 99%

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Shen

Liu

et al. 2022

Front. Genet.

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Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are one of the leading causes of pediatric mortality. Studies have shown that circRNAs play an important regulatory role in the development of childhood malignant solid tumors, hence are potential biomarkers and therapeutic targets for tumors. This paper reviews the biological characteristics and functions of circRNAs as well as the research progress related to childhood malignant solid tumors.

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“…According to the location of transcription, lncRNAs are classified into intronic and intergenic. Structurally, lncRNAs can be found in linear and circular forms, which are mainly referred to as the former structures; however, circular RNAs also have been found with regulatory functions and roles in pathogenesis of various human cancers ( Rahmati et al, 2021 ; Sayad et al, 2021 ). LncRNAs show specific expression in cell-, tissue-, and developmental stage–specific manners ( Sarropoulos et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials

Najafi

Ghafouri‐Fard

Hussen

et al. 2022

Front. Cell Dev. Biol.

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Long noncoding RNAs (lncRNAs) are a class of noncoding transcripts characterized with more than 200 nucleotides of length. Unlike their names, some short open reading frames are recognized for them encoding small proteins. LncRNAs are found to play regulatory roles in essential cellular processes such as cell growth and apoptosis. Therefore, an increasing number of lncRNAs are identified with dysregulation in a wide variety of human cancers. SNHG7 is an lncRNA with upregulation in cancer cells and tissues. It is frequently reported with potency of promoting malignant cell behaviors in vitro and in vivo. Like oncogenic/tumor suppressor lncRNAs, SNHG7 is found to exert its tumorigenic functions through interaction with other biological substances. These include sponging target miRNAs (various numbers are identified), regulation of several signaling pathways, transcription factors, and effector proteins. Importantly, clinical studies demonstrate association between high SNHG7 expression and clinicopathological features in cancerous patients, worse prognosis, and enhanced chemoresistance. In this review, we summarize recent studies in three eras of cell, animal, and human experiments to bold the prognostic, diagnostic, and therapeutic potentials.

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CiRS-7/CDR1as; An oncogenic circular RNA as a potential cancer biomarker

Cited by 31 publications

References 77 publications

Network Approaches to Study Endogenous RNA Competition and Its Impact on Tissue-Specific microRNA Functions

Network Approaches to Study Endogenous RNA Competition and Its Impact on Tissue-Specific microRNA Functions

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Oncogenic Roles of Small Nucleolar RNA Host Gene 7 (SNHG7) Long Noncoding RNA in Human Cancers and Potentials

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