Cirrhotic patients and older people

Freitas, Laura Bainy Rodrigues de; Longo, Larisse; Santos, Deivid Cruz dos; Grivicich, Ivana; Álvares‐da‐Silva, Mário Reis

doi:10.4254/wjh.v11.i9.678

Cited by 28 publications

(16 citation statements)

References 202 publications

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“…HCC and cirrhosis had the highest association, and produced the following comorbidity pattern: HCC, cirrhosis, chronic viral hepatitis B, portal hypertension, ascites, hypersplenism, peritonitis and other common complications of cirrhosis. Previous comorbidity studies on cirrhosis revealed that portal hypertension, ascites and other above diseases are common comorbidities of cirrhosis [31,32]. Compared with the literature [33,34], our study reports a high rate of HCC without associated cirrhosis.…”

Section: Discussionsupporting

confidence: 38%

Patterns of Comorbidity in Hepatocellular Carcinoma: A Network Perspective

Wang

Jiang

et al. 2020

IJERPH

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Hepatocellular carcinoma (HCC) is a common and fatal cancer. People with HCC report higher odds of comorbidity compared with people without HCC. To explore the association between HCC and medical comorbidity, we used routinely collected clinical data and applied a network perspective. In the network perspective, we used correlation analysis and community detection tests that described direct relationships among comorbidities. We collected 14,891 patients with HCC living in Jilin Province, China, between 2016 and 2018. Cirrhosis was the most common comorbidity of HCC. Hypertension and renal cysts were more common in male patients, while chronic viral hepatitis C, hypersplenism, hypoproteinemia, anemia and coronary heart disease were more common in female patients. The proportion of chronic diseases in comorbidities increased with age. The main comorbidity patterns of HCC were: HCC, cirrhosis, chronic viral hepatitis B, portal hypertension, ascites and other common complications of cirrhosis; HCC, hypertension, diabetes mellitus, coronary heart disease and cerebral infarction; and HCC, hypoproteinemia, electrolyte disorders, gastrointestinal hemorrhage and hemorrhagic anemia. Our findings provide comprehensive information on comorbidity patterns of HCC, which may be used for the prevention and management of liver cancer.

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Section: Discussionsupporting

confidence: 38%

Patterns of Comorbidity in Hepatocellular Carcinoma: A Network Perspective

Wang

Jiang

et al. 2020

IJERPH

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“…On the one hand, this study shows that being older is a risk factor for frailty and prefrailty in patients with cirrhosis, which will increase the incidence of complications and reduce the quality of life. On the other hand, studies have shown that being older is a risk factor for death in patients with cirrhosis [24]. So we should pay more attention to elderly patients with cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Frailty as tested by the Liver Frailty Index in out-patient patients with cirrhosis in China: a cross-sectional study

Yuan

et al. 2022

European Journal of Gastroenterology &Amp; Hepatology

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Background Early identification and prevention of frailty are very important for patients with cirrhosis. Methods The study was the first to use Liver Frailty Index in out-patient patients with cirrhosis in China, and to analyze the influencing factors. Result This study included 387 patients with cirrhosis. Frailty was diagnosed using the Liver Frailty Index. Multiple Logistic regression model were used to analyze influencing factors of frailty in out-patient patients with cirrhosis. Frailty was diagnosed in 9.6% of patients and prefrailty was diagnosed in 54.8% of patients. Age, sex, BMI, education level, monthly economic income, number of unplanned hospital admissions in the past year, cause of cirrhosis, Child-Pugh classification of cirrhosis, nutritional risk, physical activity, gait speed and Activity of Daily Living (ADL) Scale in the frailty, prefrailty and no frailty of groups were statistically significant. Age (OR, 1.103; CI, 0.064-0.132), BMI (OR, 0.817; CI, −0.302 to −0.104), education level (OR, 4.321; CI, 0.754-2.173), physical activity (OR, 3.580; CI, 0.534-2.016) and gait speed (OR, 0.001; CI, −8.188 to −4.972) were influential factors of frailty in out-patient patients with cirrhosis. Conclusion Out-patient patients with cirrhosis have a high incidence of frailty and prefrailty. Elderly, reduced gait speed, no physical activity and low culture level are risk factors for frailty and prefrailty, and we should be identification and intervention early.

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“…The unsteady rates of development of liver damage under similar risk factors as well as the variability in the pathogenesis of HBV infection demonstrate that the molecular mechanism of HBV-induced cirrhosis is not fully understood. Recently, a number of functional genetic polymorphisms that likely increase the risk of liver fibrosis progression were described, which, together with other external factors such as alcohol intake, body mass index (BMI), diabetes, or hepatitis could be helpful in the determination of risk profile for the individual patient [19][20][21][22][23][24]. Moreover, host genetic background is undoubtedly involved in the development of HBV-related liver diseases [25].…”

Section: Discussionmentioning

confidence: 99%

Liver Cirrhosis in Chronic Hepatitis B Patients Is Associated with Genetic Variations in DNA Repair Pathway Genes

Rybicka

Woziwodzka

Sznarkowska

et al. 2020

Cancers

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Liver cirrhosis (LC), contributing to more than 1 million of deaths annually, is a major healthcare concern worldwide. Hepatitis B virus (HBV) is a major LC etiological factor, and 15% of patients with chronic HBV infection (CHB) develop LC within 5 years. Recently, novel host genetic determinants were shown to influence HBV lifecycle and CHB course. DNA repair enzymes can affect dynamics of liver damage and are involved in HBV covalently closed circular DNA (cccDNA) formation, an essential step for viral replication. This study aimed to evaluate the possible role of genes representing key DNA-repair pathways in HBV-induced liver damage. MALDI-TOF MS genotyping platform was applied to evaluate variations within XRCC1, XRCC4, ERCC2, ERCC5, RAD52, Mre11, and NBN genes. Apart from older age (p < 0.001), female sex (p = 0.021), portal hypertension (p < 0.001), thrombocytopenia (p < 0.001), high HBV DNA (p = 0.001), and high aspartate aminotransferase (AST) (p < 0.001), we found that G allele at rs238406 (ERCC2, p = 0.025), T allele at rs25487 (XRCC1, p = 0.012), rs13181 GG genotype (ERCC2, p = 0.034), and C allele at rs2735383 (NBN, p = 0.042) were also LC risk factors. The multivariate logistic regression model showed that rs25487 CC (p = 0.005) and rs238406 TT (p = 0.027) were independently associated with lower risk of LC. This study provides evidence for the impact of functional and potentially functional variations in key DNA-repair genes XRCC1 and ERCC2 in HBV-induced liver damage in a Caucasian population.

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Cirrhotic patients and older people

Cited by 28 publications

References 202 publications

Patterns of Comorbidity in Hepatocellular Carcinoma: A Network Perspective

Patterns of Comorbidity in Hepatocellular Carcinoma: A Network Perspective

Frailty as tested by the Liver Frailty Index in out-patient patients with cirrhosis in China: a cross-sectional study

Liver Cirrhosis in Chronic Hepatitis B Patients Is Associated with Genetic Variations in DNA Repair Pathway Genes

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