Cirrhotic cardiomyopathy

Hamoudi, Waleed Al; Lee, Samuel S.

doi:10.1016/b978-0-12-817394-7.00017-6

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Cellular Events and Morphological Changes That Regulate The ...1

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2024

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“…For example, rat fetal cardiomyocytes express MYH6, which encodes α-MHC. However, adult cardiomyocytes express β-MHC, encoded by MYH7 [ 33 , 34 , 35 ]. In contrast, humans express β-MHC in both fetal and adult cardiomyocytes [ 36 ].…”

Section: Cellular Events and Morphological Changes That Regulate The ...mentioning

confidence: 99%

Epigenetic Regulation of Mammalian Cardiomyocyte Development

Mensah,

Gowher

2024

Epigenomes

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The heart is the first organ formed during mammalian development and functions to distribute nutrients and oxygen to other parts of the developing embryo. Cardiomyocytes are the major cell types of the heart and provide both structural support and contractile function to the heart. The successful differentiation of cardiomyocytes during early development is under tight regulation by physical and molecular factors. We have reviewed current studies on epigenetic factors critical for cardiomyocyte differentiation, including DNA methylation, histone modifications, chromatin remodelers, and noncoding RNAs. This review also provides comprehensive details on structural and morphological changes associated with the differentiation of fetal and postnatal cardiomyocytes and highlights their differences. A holistic understanding of all aspects of cardiomyocyte development is critical for the successful in vitro differentiation of cardiomyocytes for therapeutic purposes.

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