Cirrhosis due to Chronic Hepatitis E Infection in a Child Post-Bone Marrow Transplant

Diagnostic Performance of Five Assays for Anti-Hepatitis E Virus IgG and IgM in a Large Cohort Study

“…However, fulminant infection sporadically occurs, and in some patients, chronic infection may ensue, often with rapid fibrosis progression leading to cirrhosis; this most commonly occurs in immunocompromised individuals, such as solid organ recipients and patients receiving chemotherapy (6)(7)(8)(9)(10)(11). Additionally, hepatitis E may be associated with neurological manifestations, such as Guillain-Barré syndrome (12), neuralgic amyotrophy (13), and meningitis (14,15).…”

Chronic Hepatitis E Resolved by Reduced Immunosuppression in Pediatric Kidney Transplant Patients

“…1 When unnoticed or left untreated, chronic HEV infection may rapidly lead to cirrhosis. 6,[12][13][14][15] Fortunately, chronic HEV infection can be successfully treated, for example by modest decreases in immunosuppression. Of course, this approach may lead to rejection of the organ transplant.…”

“…6,17 In children, few studies have been published. 12,13,[18][19][20] Only 1 study concerned children after kidney transplantation. 18 The transmission of endemic HEV is thought to occur through contaminated or undercooked food or blood transfusions, blood products, and organ transplants.…”

Chronic Hepatitis E Virus Infection and Treatment

“…18,20 HEV-related cirrhosis in a child who had undergone a bone-marrow transplant was reported. 25 A single case of HEV reactivation has been also reported in a patient with acute lymphoblastic leukemia after an allogeneic stem-cell transplant. 26 …”