Cirrhosis as an independent risk factor for colonic adenomas.

Naveau, Sylvie; Chaput, J C; Bédossa, Pierre; Poynard, Thierry; Pauphilet, C; O, Ink; Houdayer, Claude; Aubert, Alain

doi:10.1136/gut.33.4.535

Cited by 32 publications

(27 citation statements)

References 33 publications

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“…Previously published data suggest that cirrhosis per se is an independent risk factor for colorectal adenomatous polyps -with alcoholism increasing this risk. 32 Our data, together with those of previous studies showing that the risk for colorectal cancer is increased mainly in alcoholic cirrhosis, 8,13 suggest that excess alcohol consumption may be related to colorectal cancer development in adenomatous polyps in patients with cirrhosis.…”

Section: Discussionsupporting

confidence: 73%

Increased Risk for Malignant Neoplasms Among Patients With Cirrhosis

Kalaitzakis

Gunnarsdóttir

Josefsson

et al. 2011

Clinical Gastroenterology and Hepatology

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Section: Discussionsupporting

confidence: 73%

Increased Risk for Malignant Neoplasms Among Patients With Cirrhosis

Kalaitzakis

Gunnarsdóttir

Josefsson

et al. 2011

Clinical Gastroenterology and Hepatology

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“…However, in this study patients were not sex-and age-matched and the mean duration of reported alcohol abuse in ALCI patients was 5 years longer, which limits those findings. 15 Furthermore, our study also found higher rates of colorectal neoplasia in cirrhotic patients with hepatitis C virus and hepatitis B virus infection as the underlying etiology of cirrhosis. Some viral infections such as human immunodeficiency virus and subtypes of polyomaviruses including John Cunningham (JC) virus have been connected with the facilitation of colorectal carcinogenesis, however, data on the impact of viral infections are controversial.…”

Section: Discussionmentioning

confidence: 83%

A Greater Proportion of Liver Transplant Candidates Have Colorectal Neoplasia Than in the Healthy Screening Population

Jeschek

Ferlitsch

Salzl

et al. 2015

Clinical Gastroenterology and Hepatology

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“…The increased risks of cancer of the stomach and large bowel may be more difficult to explain by confounding, although stomach cancer has recently been included in the group of tobacco-related cancers. 23 Alcohol consumption has been associated with an increased risk of rectal cancer, 24,25 and Naveau et al 26 studied the effects of alcoholism and cirrhosis and found that alcoholics were three times more likely than nonalcoholics to have colon adenomatous polyps, controlling for cirrhosis. The same study showed that the prevalence of colon adenomatous polyps was over two times higher in patients with cirrhosis than in those without cirrhosis, after controlling for alcoholism.…”

Section: Discussionmentioning

confidence: 99%

Risk of liver and other types of cancer in patients with cirrhosis: A nationwide cohort study in Denmark

et al. 1998

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Cancer risk in patients with cirrhosis could be modified by factors such as changes in hormonal levels, impaired metabolism of carcinogens, or alteration of immunological status. We investigated the risk of liver and various forms of cancer in patients with cirrhosis in a follow-up study. We identified 11,605 1-year survivors of cirrhosis from the files of the Danish National Registry of Patients (NRP) from 1977 to 1989. Occurrence of cancer through 1993 was determined by linkage to the Danish Cancer Registry. For comparison, the expected number of cancer cases was estimated from national age-, sex-, and site-specific incidence rates. Overall, 1,447 cancers were diagnosed among the study subjects, as compared with 708.1 expected, to yield a standardized incidence ratio (SIR) of 2.0 (95% CI: 1.9 to 2.2). In all diagnostic subgroups of cirrhosis, the risk of primary liver cancer, mainly hepatocellular carcinoma, was markedly elevated, with 245 observed cases and an overall 36-fold elevated risk (59.9-fold elevated for hepatocellular carcinoma and 10-fold for cholangiocarcinoma). Substantial and persistent excesses during follow-up were seen for all types of cancer associated with tobacco and alcohol habits (cancer of the lung, larynx, buccal cavity, pharynx, pancreas, urinary bladder, and kidney), while moderate excesses were seen for cancers of the colon and breast. The latter, however, were not complemented by any decrease in the risk of prostate cancer (SIR: 1.0; 95% CI: 0.7 to 1.3). A slightly increased risk was seen for testis cancer, but disappeared after 10 years. We found evidence of an increased risk for liver and several extrahepatic cancers in patients with cirrhosis. Although part of this increase is likely attributable to alcohol and tobacco consumption, our study opens up the possibility that cirrhosis plays a role in the carcinogenesis of types of cancer other than liver cancer. (HEPATOLOGY 1998;28:921-925.)

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Cirrhosis as an independent risk factor for colonic adenomas.

Cited by 32 publications

References 33 publications

Increased Risk for Malignant Neoplasms Among Patients With Cirrhosis

Increased Risk for Malignant Neoplasms Among Patients With Cirrhosis

A Greater Proportion of Liver Transplant Candidates Have Colorectal Neoplasia Than in the Healthy Screening Population

Risk of liver and other types of cancer in patients with cirrhosis: A nationwide cohort study in Denmark

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