CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p/PPARA

Wang, Fu; Zhang, Fangfang; Tian, Q; Sheng, Kai

doi:10.1080/08916934.2021.2012764

Cited by 15 publications

(16 citation statements)

References 32 publications

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“…Recent studies suggested that several CircRNAs play a pivotal role in SA-AKI. [14][15][16][17][18][19][20][21][22][23] However, the function of more CircRNAs needed was demonstrated by the LPS and CLP injury models in vitro and vivo. Collectively, we verified that Circ_35953 was one of drivers of SA-AKI.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies suggested that several CircRNAs play a pivotal role in SA‐AKI 14–23 . However, the function of more CircRNAs needed to be investigated.…”

Section: Discussionmentioning

confidence: 99%

“…CircRNAs were involved in the renal cell apoptosis. For example, the CIRC‐Ttc3, circVMA21, and Circ_0091702 suppressed LPS induced the tubular cell apoptosis 14,20,21,23 . However, circTLK1, circ_0114428, circHIPK3, and circ‐FANCA promoted LPS‐induced tubular cell apoptosis 15–18 .…”

Section: Discussionmentioning

confidence: 99%

“…For example, several CircRNAs of CIRC‐Ttc3, CircTLK1, Circ_0114428, CircHIPK3, circ‐FANCA and circ‐BNIP3L mediated the progression of SA‐AKI 14–19 . By the contrast, CircRNAs of CircVMA21, Circ_0068888 and Circ_0091702 protested against the development of SA‐AKI 20–23 . The above‐mentioned findings revealed the function of parts of cirRNAs.…”

Section: Introductionmentioning

confidence: 90%

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The Circ_35953 induced by the NF‐κB mediated the septic AKI via targeting miR‐7219‐5p/HOOK3 and IGFBP7 axis

Feng

Liu

Chen³

et al. 2023

J Cellular Molecular Medi

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A few studies suggested that CircRNAs were involved in the development of septic AKI. However，the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we found that Circ_35953 was induced by LPS via activation of NF‐κB signal in BUMPT cells. Functionally, Circ_35953 mediated the LPS induced the apoptosis in BUMPT cells. Moreover, we demonstrated that Circ_35953 sponged miR‐7219‐5p to upregulate the expression of HOOK3 and IGFBP7. Finally, we verified that knock down of Circ_35953 alleviated the progression of CLP‐induced AKI via targeting the miR‐7219‐5p/HOOK3 and IGFBP7 signal. Collectively, the data suggested that Circ_35953 /miR‐7219‐5p/HOOK3 and IGFBP7 axis mediated the septic AKI, which also revealed a potential mechanism of septic AKI.

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Section: Discussionmentioning

confidence: 99%

“…Recent studies suggested that several CircRNAs play a pivotal role in SA‐AKI 14–23 . However, the function of more CircRNAs needed to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

See 2 more Smart Citations

The Circ_35953 induced by the NF‐κB mediated the septic AKI via targeting miR‐7219‐5p/HOOK3 and IGFBP7 axis

Feng

Liu

Chen³

et al. 2023

J Cellular Molecular Medi

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“…Two different studies have shown that the circRNA VMA21 can simultaneously serve as a sponge for miRNA-9-3p and miRNA-7-5p. Furthermore, up-regulation of circRNA VMA21 can alleviate sepsis-related AKI by inhibiting the expression of these two miRNAs ( Shi et al, 2020 ; Wang et al, 2022 ). Another study on the down-regulation of circRNA TTC3 in sepsis-related AKI showed that up-regulation of circRNA TTC3 can alleviate the sepsis-induced inflammatory response in renal tubular epithelial cells by targeted inhibition of miRNA-148a ( Ma X. et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation

Lin

Xia

et al. 2022

Front. Physiol.

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Acute renal injury (AKI) is a complex clinical syndrome, involving a series of pathophysiological processes, in which inflammation plays a key role. Identification and verification of gene signatures associated with inflammatory onset and progression are imperative for understanding the molecular mechanisms involved in AKI pathogenesis. Non-coding RNAs (ncRNAs), involved in epigenetic modifications of inflammatory responses, are associated with the aberrant expression of inflammation-related genes in AKI. However, its regulatory role in gene expression involves precise transcriptional regulation mechanisms which have not been fully elucidated in the complex and volatile inflammatory response of AKI. In this study, we systematically review current research on the intrinsic molecular mechanisms of ncRNAs that regulate the inflammatory response in AKI. We aim to provide potential research directions and strategies for developing ncRNA-targeted gene therapies as an intervention for the inflammatory damage in AKI.

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Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury

Peng,

Li,

Zhang

et al. 2024

Cell. Mol. Life Sci.

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Approximately 60% of septic patients developed acute kidney injury (AKI). The mortality rate of septic AKI (SA-AKI) is two to three times higher than that of septic without AKI (SA-non-AKI). The actual functions and mechanisms of CircRNAs in the pathophysiology of SA-AKI remain incompletely understood. Herein, we observed that the mmu_Circ_26986 could be induced by lipopolysaccharide (LPS) and cecum ligation and puncture (CLP) in BUMPT cell line and C57BL/6 mouse kidney, respectively. Functionally, mmu_Circ_26986 suppressed BUMPT cell apoptosis induced by LPS. Mechanistically, mmu_Circ_26986 sponged miRNA-29b-1-5p to upregulate the expression of PAK7. Overexpression of mmu_Circ_26986 ameliorated the progression of CLP-stimulated AKI through miRNA-29b-1-5p/PAK7 axis. In addition, we found that hsa_Circ_0072463, homologous to mmu_Circ_26986, suppressed LPS-induced HK-2 cells apoptosis via regulation of miRNA-29b-1-5p/PAK7 axis. Furthermore, sepsis patients with AKI had a higher level of hsa_Circ_0072463 compared to those without AKI. The sensitivity, specificity and AUC of hsa_Circ_0072463 were 78.8%, 87.9% and 0.866, respectively. Spearman's test indicated a noticeable positive correlation between plasma hsa_Circ_0072463 and serum creatinine in sepsis patients (r = 0.725). In summary, this study reveals that the mmu_Circ_26986/hsa_Circ_0072463 miRNA-29b-1-5p/PAK7 axis mediates septic AKI, and hsa_Circ_0072463 is a potential diagnostic marker for septic AKI.

show abstract

CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p/PPARA

Cited by 15 publications

References 32 publications

The Circ_35953 induced by the NF‐κB mediated the septic AKI via targeting miR‐7219‐5p/HOOK3 and IGFBP7 axis

The Circ_35953 induced by the NF‐κB mediated the septic AKI via targeting miR‐7219‐5p/HOOK3 and IGFBP7 axis

The Intersection of Acute Kidney Injury and Non-Coding RNAs: Inflammation

Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury

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