Circumventing the blood–brain barrier: Local delivery of cyclosporin A stimulates stem cells in stroke-injured rat brain

Tuladhar, Anup; Morshead, Cindi M.; Shoichet, Molly S.

doi:10.1016/j.jconrel.2015.07.023

Cited by 65 publications

(44 citation statements)

References 87 publications

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“…Epi-cortical delivery has been explored as a minimally invasive method of drug delivery to the brain (Cooke et al, 2011;Tuladhar et al, 2015). With this method a drug-loaded scaffold is implanted onto the surface of the brain, thus avoiding tissue damage caused by needle insertion as is seen with intracranial and convection-enhanced delivery.…”

Section: Local Drug Delivery To the Brainmentioning

confidence: 99%

“…The initial release, FiGURe 1 | Biomaterials can be used to delivery drugs by either (A) intracranial injection into space provided by the stroke injury or (B) epi-cortical implant on the surface of the brain to prevent any further damage due to injection. Reprinted from Tuladhar et al (2015) with permission from Elsevier.…”

Section: Controlling Drug Releasementioning

confidence: 99%

“…The materials themselves offer some neuroprotection by providing structural support, attenuating gliosis and inflammation, and reducing cavitation. Bioactive materials, like HA, reduce inflammation through the CD44 receptor by inhibiting leukocyte migration and inflammation (Forrester and Wilkinson, 1981;Cooper et al, 2008), resulting in reduced microglial activation (Wang et al, 2012b) and stroke infarct volume (Hou et al, 2005;Austin et al, 2012;Wang et al, 2013;Tuladhar et al, 2015).…”

Section: Protecting Neural Cellsmentioning

confidence: 99%

“…While a clear tissue benefit was seen, it is unknown whether this was accompanied by behavioral recovery. Epi-cortical delivery has also been tested in the larger rat model with cyclosporine, demonstrating sufficient tissue penetration to stimulate proliferating endogenous NSPCs (Tuladhar et al, 2015).…”

Section: Stimulating Endogenous Stem Cellsmentioning

confidence: 99%

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Harnessing the Potential of Biomaterials for Brain Repair after Stroke

2018

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Section: Local Drug Delivery To the Brainmentioning

confidence: 99%

Section: Controlling Drug Releasementioning

confidence: 99%

Section: Protecting Neural Cellsmentioning

confidence: 99%

Section: Stimulating Endogenous Stem Cellsmentioning

confidence: 99%

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Harnessing the Potential of Biomaterials for Brain Repair after Stroke

2018

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“…The Shoichet lab has engineered an injectable physically crosslinked hydrogel composed of a hyaluronan/methylcellulose (HAMC) blend. This hydrogel is applied epi-cortically through injection (Figure 3) and has been used to achieve sustained and sequential delivery of erythopoietin [30] [30,31], epidermal growth factor (EGF) [32] and most recently cyclosporine A (CsA) [33]. Encapsulated EGF released from this system increased NPC proliferation in uninjured and stroke-injured brains, while modifying EGF with polyethylene glycol (PEG) significantly enhanced protein stability, diffusion distance, and in vivo bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for brain repair after stroke: an emerging treatment option

Nih

Carmichael

Segura

2016

Current Opinion in Biotechnology

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Stroke disability is the only major disease without an effective treatment. The substantial clinical burden of stroke in disabled survivors and the lack of a medical therapy that promotes recovery provide an opportunity to explore the use of biomaterials to promote brain repair after stroke. Hydrogels can be injected as a liquid and solidify in situ to form a gelatinous solid with similar mechanical properties to the brain. These biomaterials have been recently explored to generate pro-repair environments within the damaged organ. This review highlights the clinical problem of stroke treatment and discusses recent advances in using in situ forming hydrogels for brain repair.

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Advanced Functional Materials and Cell‐Based Therapies for the Treatment of Ischemic Stroke and Postischemic Stroke Effects

Tapeinos

Larrañaga

Tomatis

et al. 2019

Adv Funct Materials

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Ischemic stroke is considered one of the most threatening neurological disorders with high percentages of mortality and morbidity worldwide. Although in recent years, several nanotechnological advances have improved the survival rates, severe untreated poststroke side‐effects continue to significantly influence the way of life of many. Tissue plasminogen activator and mechanical thrombectomy are considered the gold standards for the treatment of acute cerebral ischemia. These, however, fail to improve postischemic disorders. Herein, after a brief description of the pathophysiology of ischemic stroke and the following biochemical cascade, the most recent biomaterial and cell‐based strategies are reviewed for its treatment. Other therapeutics that have been proposed not only for the treatment of cerebral ischemia but also for the regeneration of the infarcted brain that is responsible for a variety of disorders, including cognitive, motor, and speech problems are also presented. Finally, a few reported studies on diagnostic and theranostic nanostructures are also provided.

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Circumventing the blood–brain barrier: Local delivery of cyclosporin A stimulates stem cells in stroke-injured rat brain

Cited by 65 publications

References 87 publications

Harnessing the Potential of Biomaterials for Brain Repair after Stroke

Harnessing the Potential of Biomaterials for Brain Repair after Stroke

Hydrogels for brain repair after stroke: an emerging treatment option

Advanced Functional Materials and Cell‐Based Therapies for the Treatment of Ischemic Stroke and Postischemic Stroke Effects

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