Circumscribed palmar or plantar hypokeratosis: A distinctive epidermal malformation of the palms or soles

Pérez, Amparo Sancho; Rütten, Arno; Gold, Reinhard; Urbina, Francisco Zúñiga; Misad, Carlos; Izquierdo, M J; Requena, Celia; Aliaga, Adolfo; Kutzner, Heinz; Requena, Luís

doi:10.1067/mjd.2002.120466

Cited by 120 publications

(143 citation statements)

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“…A palmoplantar variant, which mainly presents in childhood, affects palms and soles exclusively. 1,6 In contrast with porokeratosis of Mibelli, circumscribed palmar or plantar hypokeratosis does not show cornoid lamella, and the granular cell layer is present in the whole epidermal depression. Other characteristic histopathological findings of porokeratosis are pycnotic or dyskeratotic keratinocytes, and a moderate inflammatory infiltrate in the papillary dermis, below the cornoid lamella.…”

Section: Case Reportmentioning

confidence: 99%

“…Granular cell layer may be slightly thinner in the epidermis covering the depression. 1 Other possible features, reported in isolated cases, include focal parakeratosis, epidermal hyperplasia, mild dermal inflammation, and elastosis. 5 Circumscribed palmar or plantar hypokeratosis should be mostly differentiated from porokeratosis of Mibelli, Bowen's disease, and from the base of a frictional blister.…”

Section: Case Reportmentioning

confidence: 99%

“…Other characteristic histopathological findings of porokeratosis are pycnotic or dyskeratotic keratinocytes, and a moderate inflammatory infiltrate in the papillary dermis, below the cornoid lamella. 1 Bowen's disease presents with an erythematous, desquamatory, slow-growing plaque. Microscopically, there was full thickness epidermal atypia.…”

Section: Case Reportmentioning

confidence: 99%

“…5 Circumscribed palmar or plantar hypokeratosis should be mostly differentiated from porokeratosis of Mibelli, Bowen's disease, and from the base of a frictional blister. 1,2,6 Porokeratosis of Mibelli consists on annular plaques surrounded by a keratotic ring with centrifugal spread. A palmoplantar variant, which mainly presents in childhood, affects palms and soles exclusively.…”

Section: Case Reportmentioning

confidence: 99%

“…1 Its origin is not completely clarified. The condition presents a highly characteristic clinical and histological picture.…”

Section: Introductionmentioning

confidence: 99%

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Circumscribed plantar hypokeratosis responding to topical calcipotriol

Batalla

Torre

2013

J Dermatol Case Rep

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Background: Circumscribed palmar or plantar hypokeratosis defines a benign condition clinically presented as a well-defined depressed area on the skin. It is characterized by a peculiar histopathological picture with the abrupt thinning of the horny layer of the epidermis. Main observations:We present a case of a 17-year-old man, who presented with a one-year history of an occasionally painful lesion on his right sole. The diagnosis of circumscribed plantar hypokeratosis was confirmed by histopathology. The lesion was successfully treated with calcipotriol ointment. Conclusions:Circumscribed palmar or plantar hypokeratosis is a benign condition that typically affects the hands. Different therapeutic approaches have been unsuccessful. In our patient the lesion was at a less frequent plantar location and the lesion responded to topical calcipotriol. (J Dermatol Case Rep.

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%