Circulatory Shock, Histamine, and Antihistamines: Therapeutic Aspects

Altura, Burton M.; Halevy, S

doi:10.1007/978-3-642-66445-8_15

Cited by 5 publications

(3 citation statements)

References 111 publications

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“…Over the past decades numerous publications originating from various medical disciplines dealt with problems of release of biogenic amines (histamine, catecholamines, serotonin) in response to any kind of stress (Schayer 1961, Erspamer 1966; Rocha e Silva 1966; Blaschko and Muscholl 1972;Altura and Halevy 1978;Vane and Ferraira 1978). Their role in general cardiovascular reactions like tachycardia, arrhythmia, hypotension and in microcirculatory responses such as oedema, thrombosis and hypoxic tissue damage is still poorly understood, but for obvious reasons these questions are of major interest in surgery.…”

Section: Sehlfisselwiirter: Standardoperationen -An~isthesie -Bluttramentioning

confidence: 99%

Plasma histamine levels in patients in the course of several standard operations: Influence of anaesthesia, surgical trauma and blood transfusion

et al. 1982

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Summary.A prospective controlled clinical trial was conducted on changes in plasma histamine and catecholamine levels during 5 standard operations. This communication, as the first part of the trial, deals only with the feasibility of such a trial and the changes in plasma histamine levels.Elevated histamine concentrations corresponding to histamine-release responses of > 1 ng/ml occurred in 8 of 25 operations. In an explorative analysis these reponses were associated with distinct phases of anaesthesia or the surgical procedure.Blood transfusion carried the risk of infusion of "free histamine" into the patient -especially when administerea under pressure.Since during operations "free histamine" enters the circulation with a rather high incidence and may cause harmful effects, premedication with Hl-+Hz-receptor antagonists seems worth consideration.Key words: Standard operations anaesthesia -blood transfusion -plasma histamine Plasmahistaminspiegel bei Patienten im Verlauf von versehiedenen Standardoperationen: Einflufl yon An/isthesie, chirurgisehem Trauma und BluttransfusionZusammenfassung. Eine prospektive kontrollierte klinische Studie wurde fiber Ver/inderungen des Plasmahistamin-und Katecholaminspiegels bei 5 Standardoperationen durchgeffihrt. Diese Mitteilung, als erster Teil der Studie, zeigt nur die M6gtichkeiten auf, eine solche Studie durchzuf/ihren und Ver/inderungen des Plasmahistaminspiegels nachzuweisen.Erh6hte Plasmahistaminkonzentrationen, die einer Histaminfreisetzungsreaktion yon > 1 ng/ml entsprechen, kamen bei 8 yon 25 Operationen vor. In einer explorativen statistischen Analyse wurden diese Reaktionen mit bestimmten Phasen der An/isthesie oder des chirurgischen Eingriffs in Verbindung gebracht.Bluttransfusionen tragen das Risiko in sich, ,,freies Histamin" in den Patienten zu infundieren -zumal bei Filterpassage, wenn es unter erhthtem Druck angewandt wird.

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Section: Sehlfisselwiirter: Standardoperationen -An~isthesie -Bluttramentioning

confidence: 99%

Plasma histamine levels in patients in the course of several standard operations: Influence of anaesthesia, surgical trauma and blood transfusion

et al. 1982

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“…It is the sum of these histamine release or histamine administration situations which we consider as clinically relevant although the outcome studies on this problem are not yet completed . As in the case of several groups of drugs analysed previously, earlier reports on elevated histamine levels in body fluids were also published for standard surgical situations: for ileus see FELDBERG and SCHILF (1930); for trauma and burns see GUGGENHEIM (1951) and ALTURA and HALEVY (1978). However, these studies -based on the paradigm that histamine has functions in inflammation -created useful hypotheses to test the pathophysiological role of histamine, but they were unable to withstand the demands of a reliable histamine assay and clinical study design as are necessary to provide convincing evidence today with almost 100 other competing mediators (NEUGEBAUER et al 1987a,b;NEUGEBAUER and LORENZ 1988).…”

Section: Surgical Manoeuvres and Other Physical And Chemical Meamentioning

confidence: 94%

“…la-d and Table l. They can be used both for the modified Koch-Dale criteria as defined by ALTURA and HALEVY (1978) and LORENZ et ai. (1984a) and for the nine criteria of HILL (1965) for establishing causal associations between aetiology (e.g.…”

Section: Hypnotic Agents and The Criteria For Causal Associationsmentioning

confidence: 99%