Circulatory responses at the onset of handgrip exercise in patients with Parkinson's disease

Sabino‐Carvalho, Jeann L.; Samora, Milena; Teixeira, André L.; Daher, Maurício; Vianna, Lauro C.

doi:10.1113/ep087620

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…In addition to these positive effects, exercise has been employed as a coping resource to manage the quality of life (Corcos et al, 2013) and sleep (Silva-Batista et al, 2017), motor function (David et al, 2016;Vieira-Yano et al, 2020;Silva-Batista et al, 2020b), physical capacity (Kelly et al, 2014), fatigue (Santos et al, 2016) of patients with PD, and disease progression in a PD animal model (Zhou et al, 2017). Despite this, exercise training could be a challenging approach in this population, especially in those patients with OH (Roberson et al, 2019;Sabino-Carvalho et al, 2019;, because of the impaired autonomic function (Goldstein, 2014;Vianna et al, 2016).…”

Section: Exercise Training In Pdmentioning

confidence: 99%

Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise

2021

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Parkinson’s disease (PD) is a common neurodegenerative disorder classically characterized by symptoms of motor impairment (e.g., tremor and rigidity), but also presenting with important non-motor impairments. There is evidence for the reduced activity of both the parasympathetic and sympathetic limbs of the autonomic nervous system at rest in PD. Moreover, inappropriate autonomic adjustments accompany exercise, which can lead to inadequate hemodynamic responses, the failure to match the metabolic demands of working skeletal muscle and exercise intolerance. The underlying mechanisms remain unclear, but relevant alterations in several discrete central regions (e.g., dorsal motor nucleus of the vagus nerve, intermediolateral cell column) have been identified. Herein, we critically evaluate the clinically significant and complex associations between the autonomic dysfunction, fatigue and exercise capacity in PD.

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Section: Exercise Training In Pdmentioning

confidence: 99%

Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise

2021

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“…19 Studies have shown that cardiovascular responses to exercise are generally blunted in patients with PD compared to age-matched controls. [20][21][22][23][24] While in healthy subjects these attenuated responses indicate a possible adaptation to chronic exercise exposure, for patients it could indicate decreased exercise efficiency. Together with the central degeneration of important cardiovascular control areas in the brain, our group 23 recently demonstrated that an altered metabolic component of the exercise pressor reflex (EPR; predominantly group III/IV afferents) contributes to the attenuated pressor responses observed during exercise in patients with PD.…”

Section: Introductionmentioning

confidence: 99%

Altered cardiorespiratory regulation during exercise in patients with Parkinson’s disease: A challenging non-motor feature

Sabino‐Carvalho

Vianna

2020

SAGE Open Medicine

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The incidence of Parkinson’s disease is increasing worldwide. The motor dysfunctions are the hallmark of the disease, but patients also experience non-motor impairments, and over 40% of the patients experience coexistent abnormalities, such as orthostatic hypotension. Exercise training has been suggested as a coping resource to alleviate Parkinson’s disease symptoms and delay disease progression. However, the body of knowledge is showing that the cardiovascular response to exercise in patients with Parkinson’s disease is altered. Adequate cardiovascular and hemodynamic adjustments to exercise are necessary to meet the metabolic demands of working skeletal muscle properly. Therefore, since Parkinson’s disease affects parasympathetic and sympathetic branches of the autonomic nervous system and the latter are crucial in ensuring these adjustments are adequately made, the understanding of these responses during exercise in this population is necessary. Several neural control mechanisms are responsible for the autonomic changes in the cardiovascular and hemodynamic systems seen during exercise. In this sense, the purpose of the present work is to review the current knowledge regarding the cardiovascular responses to dynamic and isometric/resistance exercise as well as the mechanisms by which the body maintains appropriate perfusion pressure to all organs during exercise in patients with Parkinson’s disease. Results from patients with Parkinson’s disease and animal models of Parkinson’s disease provide the reader with a well-rounded knowledge base. Through this, we will highlight what is known and not known about how the neural control of circulation is responding during exercise and the adaptations that occur when individuals exercise regularly.

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“…106 Furthermore, they also identified augmented pressure and total peripheral resistance (TPR) responses during the onset of IHG in PD, however, after 20 seconds of exercise, the blood pressure increase was blunted comparable to the older group. 268 In both studies, the PD groups maintained elevated and similar responses for MAP, SBP, DBP, and TPR and no changes in stroke volume throughout IHG and PECO. 106 In the present study, both PD groups also had increases in heart rates during IHG which decreased significantly towards baseline during PECO.…”

Section: Effects Of Exercise Training On Hemodynamic Responses To Exercisementioning

confidence: 74%

Physiological Benefits of High-intensity Interval Training for Individuals With Parkinson's Disease

Duplea¹

2019

CMR

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This thesis investigated the effects of high intensity interval training (HIIT) and continuous moderate intensity training (CMIT) on maximal exercise capacity (VO2max), resting and exercising hemodynamics, and clinical symptoms in eighteen men and women with Parkinson's Disease. Participants were randomized to HIIT (n=9), or CMIT (n=9) groups and completed two pre-training visits. Participants completed clinical questionnaires and performed a progressive exercise test to determine VO2max. Measurements of arterial stiffness and wave reflection characteristics were recorded. Continuous hemodynamic measurements were recorded during a 2-minute isometric handgrip contraction followed by 3-minutes of post-exercise circulatory occlusion. Participants then completed 10 weeks (3x/week; 1 hour/session) of HIIT or CMIT at the Guelph YMCA followed by the same two days of post-testing. HIIT provided clinically relevant improvements in VO2max, UPDRS part III, and BDI-II scores which were greater compared to CMIT. Both exercise protocols provided no improvements in fatigue and resting or exercising hemodynamics. iii Acknowledgements I would like to start by acknowledging the incredible support my family and friends provided me not only throughout the past two-year journey, but throughout my entire life. Thank you so much for your selflessness and encouragement. I am forever grateful and will continue to push forward, knowing I have you all by my side. Thank you. Secondly, I would like to acknowledge my advisor, Dr. Philip Millar. When I first began this two-year journey, I did not know what to expect, where to start and how to truly think like a scientist. However, after working with you, I have learned to be more independent, persistent, and communicative. Thank you for always being available to your students and putting in countless hours of your time towards us, even when you had other commitments. You are a great role model and your passion for research is contagious.I would also like to acknowledge my committee members Dr. Lori Vallis and Dr. Jamie Burr. Thank you for your continuous help throughout the entire two-year process. Thank you for being so flexible with your time, especially during the numerous testing visits. I also want to thank all of your lab members for their time and flexibility. Without the support from you all, the study would not be where it is today.Finally, I would like to thank my lab mates, Anthony, Jordan, Massimo, Andre, Muhammad, Joseph, and Mitchell. Thank you for all the help and support during this process. I am very lucky to have had such dependable and kind peers. A special thanks to Anthony and Jordan for being great role models and always being there when I had any questions or issues.

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Circulatory responses at the onset of handgrip exercise in patients with Parkinson's disease

Cited by 10 publications

References 32 publications

Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise

Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise

Altered cardiorespiratory regulation during exercise in patients with Parkinson’s disease: A challenging non-motor feature

Physiological Benefits of High-intensity Interval Training for Individuals With Parkinson's Disease

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