Circulatory parameters in the retrobulbar central retinal artery and vein of patients with diabetes and medically treated systemic hypertension

Abstract

Medically treated hypertension affects the retrobulbar circulatory parameters in the central retinal artery and vein in diabetes.

Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF/ERK/FAK/Src Pathway Signaling

“…Abnormal retinal vasoconstriction has been proven to result in severe vitreous cavity hemorrhage or retinal detachment [58]. Dimitrova et al used color Doppler ultrasound to provide evidence that RI is significantly increased in the posterior ciliary artery and central retinal artery of diabetic retinas [59]. In our study, RI was increased in the DR group, but it was attenuated in the DR +SCU group, showing that SCU effectively alleviated DRinduced vasoconstriction.…”

Pulmonary Function and Retrobulbar Hemodynamics in Subjects With Type 2 Diabetes Mellitus

“…Color Doppler imaging is used to evaluate the circulatory parameters of the retrobulbar blood vessels, and scanning laser Doppler flowmetry (a useful method to evaluate blood flow in the retinal tissue) has been widely applied in ophthalmic pathology for many years. 35,36 A study by Dimitrova et al 8 showed a positive correlation between the recordings of scanning laser Doppler flowmetry of retinal tissue and the retrobulbar circulatory parameters of the color Doppler imaging in diabetes patients without diabetic retinopathy. Dimitrova reported a significantly increased arteria ophthalmica, enddiastolic velocity, and resistivity index in the central retinal vein due to the progression of the retinopathy over a 21-month period; however, no significantly altered circulatory parameters in the central retinal artery or posterior ciliary artery were recorded after the progression of diabetic retinopathy.…”

“…7 Compared with healthy individuals without concomitant diabetes and systemic hypertension, patients with hyperglycemia and uncontrolled blood pressure have significantly increased blood flow as estimated by color Doppler imaging. 8 The retrobulbar resistivity index can be used to assess hemodynamic changes in diabetic retinopathy. 9,10 To the best of our knowledge, there are no reports on the correlation between pulmonary function and the bilateral retrobulbar resistivity index in patients with type 2 diabetes and without diabetic retinopathy.…”

Isolated unilateral disk edema

“…Increased peripheral vascular resistance within the ONH vasculature -which is exacerbated by atherosclerotic and arteriosclerotic changes -due to endothelial dysfunction and decreased nitric oxide production (thereby limiting local vasodilation) would lead to loss of ocular blood flow and decreased perfusion of the ONH and eye. [280][281][282][283] The ensuing localized, relative ischemia/inflammation could alter microtubule function via this theorized pathway.…”