Circulatory Imbalance of Essential and Toxic Trace Elements in Pre-dialysis and Hemodialysis Patients

Stojsavljević, Aleksandar; Ristić‐Medić, Danijela; Krstić, Đurđa; Rovčanin, Branislav; Radjen, Slavica; Terzić, Brankica; Manojlović, Dragan

doi:10.1007/s12011-021-02940-7

Cited by 9 publications

(17 citation statements)

References 28 publications

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“…As CKD progresses, GFR decreases, leading to an imbalance of certain trace elements, and higher CKD stages are associated with increased levels of Cu and decreased levels of Zn ( 153 ). This suggests the Cu/Zn ratio could be used as a marker for early and late detection of renal failure ( 154 ). Elevated circulating Cu levels may be a causal risk factor for CKD ( 155 ), although there are varying reports of Cu concentrations in patients on HD, such as moderate Cu deficiency, high Cu levels, or Cu toxicity ( 156 ).…”

Section: Discussionmentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

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Background and Objective: Chronic kidney disease (CKD) is an important public health concern.With the decline of renal function, CKD patients gradually progress to end-stage kidney disease and need to undergo dialysis or kidney transplantation to maintain life, bringing a heavy economic burden to the family and society. Therefore, it is necessary to effectively prevent and delay the progression of CKD. Essential trace elements play an indispensable role in CKD, and the objective of this study is to systematically review their benefits in the disease and summarize the risks of their excess.Methods: The keywords "trace elements", "chronic kidney disease", "dialysis", "inflammation", and "fibrosis" and their combinations were used to search for relevant literature published in the PubMed database and Web of Science. We then summarized the role of trace element abnormalities in CKD patients in anemia, oxidative stress, inflammation, and chronic fibrosis, and the risk of their excess.

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Section: Discussionmentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

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“…In their systematic review with meta-analysis, Tonelli et al ( 2009) reported lower Mn concentration in HD patients [21]. More recently, Almeida et al (2020) also found a significantly lower serum Mn concentration in HD patients, but Stojsavljević et al (2022) reported increased Mn concentrations [15,34]. It should be noted, as mentioned before, that 96% of circulating Mn is found in erythrocytes, leucocytes and platelets, while only 4% is present in plasma [32].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that HD patients are at an increased risk of trace element imbalances [15][16][17][18][19][20][21][22][23]. While the concentration of essential trace elements may be decreased due to the inflammatory nature of the disease [24][25][26], lower food intake due to uremic anorexia or dietary restrictions [27][28][29] or losses during dialysis sessions [30], the concentration of non-essential/toxic trace elements may be increased due to loss of ability to excrete them in urine [31], among other factors.…”

Section: Introductionmentioning

confidence: 99%

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Further Evidence on Trace Element Imbalances in Haemodialysis Patients—Paired Analysis of Blood and Serum Samples

et al. 2023

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Previous studies have shown that haemodialysis patients have an increased risk of trace element imbalances. Most studies have determined the concentration of trace elements in serum only, but most trace elements are not uniformly distributed between plasma and blood cells, which justifies separate analysis of the different compartments. In this study, we determined both the serum and whole blood concentration of a wide panel of trace elements (Li, B, Mn, Co, Ni, Cu, Zn, Se, Rb, Sr, Mo, Cd, Pb) in haemodialysis patients and compared them with those of a control group. Whole blood and serum samples were collected during routine laboratory testing of patients undergoing chronic haemodialysis. For comparison purposes, samples from individuals with normal renal function were also analysed. Statistically significant differences (p < 0.05) were found between the two groups for whole blood concentrations of all analysed elements except Zn (p = 0.347). For serum, the difference between groups was statistically significant for all elements (p < 0.05). This study confirms that patients on haemodialysis tend to present significant trace element imbalances. By determining the concentration of trace elements in both whole blood and serum, it was shown that chronic haemodialysis may affect intra- and extracellular blood compartments differently.

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“…Zn is an essential trace element in the human body, which has anti-inflammatory and anti-oxidant effects [ 149 , 150 ]. Zn deficiency is common in dialysis patients [ 148 , 151 ]. In 2009, Sahin et al.…”

Section: Advances In Research On Trace Elements and Malnutritionmentioning

confidence: 99%

Progress in the study of nutritional status and selenium in dialysis patients

et al. 2023

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Malnutrition is very common in patients with chronic kidney disease, especially in those on maintenance dialysis. Malnutrition is one of the major factors affecting survival and death of dialysis patients, and reducing their activity tolerance and immunity. There are numerous and interacting risk factors for malnutrition, such as reduced nutritional intake, increased energy expenditure, hormonal disorders, and inflammation. Selenium, in the form of selenoproteins, is involved in many physiological processes in the body and plays an important role in maintaining redox homeostasis. Oxidative stress and infection are very common in dialysis patients, and selenium levels in dialysis patients are significantly lower than those in the healthy population. It has been shown that there is a correlation between selenium levels in hemodialysis patients and their nutrition-related indicators, and that selenium supplementation may improve malnutrition in patients. However, further studies are needed to support this conclusion and there is a lack of basic research to further characterize the potential mechanisms by which selenium may improve malnutrition in dialysis patients. The purpose of this review is to provide a comprehensive overview of factors associated with malnutrition in dialysis patients and to describe the progress of research on nutritional status and selenium levels in dialysis patients.

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Circulatory Imbalance of Essential and Toxic Trace Elements in Pre-dialysis and Hemodialysis Patients

Cited by 9 publications

References 28 publications

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Further Evidence on Trace Element Imbalances in Haemodialysis Patients—Paired Analysis of Blood and Serum Samples

Progress in the study of nutritional status and selenium in dialysis patients

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