Circulational heat dissipation of upper airway: Canine model of inhalational thermal injury

Development of an in vivo model of laryngeal burn injury

“…These experiments were conducted in sheep, goats, pigs, and rabbits given obvious obstacles to human experimentation . In those studies, smoke inhalation was typically achieved using unbleached cotton to avoid chemical irritation distinct from the effects of smoke, unless chemical irritation was a component of study design …”

“…[9][10][11][12][13][14] In those studies, smoke inhalation was typically achieved using unbleached cotton to avoid chemical irritation distinct from the effects of smoke, unless chemical irritation was a component of study design. 10,13,15,16 Cheng et al evaluated the effects of heat on the larynx in a canine model, employing three conditions (808C, 1608C, and 3208C) without smoke. 15 These temperatures appear relevant because a fully developed house fire is associated with temperatures above 5508C, with exposure varying based on proximity to the fire.…”

Mucosal fluid evaporation is not the method of heat dissipation from fourth-degree laryngopharyngeal burns

“…where ρ −air is the density of moist air; V −air is the volume of moist air; V t is the tidal volume of the dog (300 ml) 16 ; f is the respiratory rate; and t is the time of heated air inhalation.…”

“…Mucosal fluid evaporation has been reported as one possible self-protective mechanism from thermal injury of the airway 2 3 4 5 . Mucosal fluid protects the airway by absorbing and evaporating heat from the inhaled thermal air.…”