Circulation of two different variants of intergenic region (IGR) located between the
            <i>I73R</i>
            and
            <i>I329L</i>
            genes of African swine fever virus strains in Vietnam

Tran, Ha Thi Thanh; Truong, Anh Duc; Dang, Anh Kieu; Ly, Duc Viet; Nguyen, Chinh; Chu, Nhu Thi; Hoang, Tuan Van; Nguyen, Hoa Thi Minh; Dang, Hoang Vu

doi:10.1111/tbed.13996

Cited by 25 publications

(29 citation statements)

References 14 publications

(25 reference statements)

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“…Understanding the genetic basis for ASFV spread and adaptation among hosts will facilitate vaccine development (Bao et al, 2021). As reported in this Special Issue, ASFV genotype II isolates identical to those isolated in China and Russia have also been found in Mongolia (Ankhanbaatar et al, 2021), in India (Rajukumar et al, 2021) and in Indonesia (Indi Dharmayanti et al, 2021), although ASFV variants in the domestic pig population in Vietnam have also been detected (Tran et al, 2021). Monitoring the genetic characteristics of ASFV isolates is needed to understand the spread of this disease across countries (Minoungou et al, 2021).…”

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confidence: 91%

African Swine Fever, the forgotten pandemic

Ward

Tian

Nowotny

2021

Transbound. Emerg. Dis.

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African Swine Fever (ASF) is one of the most important diseases prevalent in swine populations. In recent times, it has devasted the pork industry-both commercial and backyard-throughout much of the world. ASF virus (ASFV) is highly contagious, and its persistence in pig meat, feed, fomites and the environment has facilitated its transboundary spread. Despite the global spread and impact of ASF, this pandemic has not garnered the widespread attention or alarm that has human diseases. Outside of the animal health community, in many respects it is the forgotten pandemic.One hundred years ago, the first scientific publication on "a form of swine fever" (to later be called African Swine Fever) that was being observed in East Africa was published by R. Eustace Montgomery. As Penrith et al. (2021) describe in this Special Issue, remarkably the key findings made by Montgomery have since been verified, and they state that "one hundred years after the discovery, the world is still grappling with the ASF virus . . . the struggle continues on all fronts".

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confidence: 91%

African Swine Fever, the forgotten pandemic

Ward

Tian

Nowotny

2021

Transbound. Emerg. Dis.

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“…We have shown that two ASFV strains, ASFV/VN/Pig/Hanoi/02 and ASFV/VN/Pig/Hanoi/07, obtained from the Thach That district of Hanoi city, belonged to B646L genotype II, EP402Rv serotype 8 and were closely related to strains circulating in China (Tran et al, 2021).…”

mentioning

confidence: 98%

mentioning

confidence: 99%

“…From early February 2019, an ASF outbreak in Vietnam was reported officially, and within seven months, ASF had spread across the whole country. Approximately six million pigs on infected farms and households have been culled, indicating the socio‐economic impact on the pig industry (Tran et al., 2021 ; Truong et al., 2020 ).…”

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confidence: 99%

“…Our previous reports that the ASFV strains circulating in Vietnam belong to B646L (p72) genotype II and EP402R (CD2v) serotype 8 and that there are least two different variants based on the intergenic region located between the I73R and I329L genes (Tran et al., 2021 ). Most investigations of ASFV genotypes have been identified based on sequencing of the B646L and E183L (p54) genes and/or analysis of the central variable region or intergenic region (IGR) between I73R and I329L genes (Gallardo et al., 2009 ; Gallardo et al., 2014 ).…”

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confidence: 99%

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Novel method for sub‐grouping of genotype II African swine fever viruses based on the intergenic region between the A179L and A137R genes

Tran

Truong

Dang

et al. 2021

Veterinary Medicine & Sci

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Background: African swine fever (ASF) is a highly contagious and deadly viral disease affecting domestic and wild pigs of all ages. African swine fever virus (ASFV) has spread rapidly through Eastern and Southeastern Asia first appearing in Vietnam in 2019.Objectives: Molecular typing of African swine fever virus (ASFV) in Vietnam has identified two principal variants circulating based on the sequencing of the intergenic region (IRG) between the I73R and I329L genes. Identification of additional genetic markers would enable higher resolution tracing of outbreaks within the country.Methods: Sequence analysis suggested the IRG between the A179L and A137R genes may also exhibit variability, PCR primers were designed and samples from Vietnam were subject to Sanger sequencing. Results:We developed a novel method for sub-grouping of ASFV based on the IRG between the A179L and A137R genes of ASFV. Our results demonstrated that the finding of the insertion or deletion of an 11-nucleotide sequence (GATACAATTGT) between the A179L-A137R genes. Conclusions:The sub-grouping method may provide useful insights into the evolution of genotype II ASFV as well as providing evidence of a relationship between geographically separated outbreaks.

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