Circulation of all dengue virus serotypes during dengue outbreak in Sandakan, Sabah, Malaysia (2016)

Gintarong, Timothy Jr; Emran, Amalina; Sherin, Aza; Thein, Tin Tin; Aung, Thida

doi:10.4103/0972-9062.242566

Cited by 11 publications

(5 citation statements)

References 5 publications

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“…Previous studies showed that all DENVs circulated continuously in Thailand with different trends for each serotype [9, 10]. This situation is not unique as DENV serotypes are endemic in many countries, resulting in so called hyperendemicity [11–16]. However, even though it was proposed that the hyperendemicity could aggravate the frequency of dengue severe symptoms, the relationship between concurrent infection and disease severity remain contradictory, with variable conclusions depending on the studies [17].…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic analysis revealed the co-circulation of four dengue virus serotypes in Southern Thailand

et al. 2019

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Dengue fever is caused by dengue viruses (DENV) from the Flavivirus genus and is the most prevalent arboviral disease. DENV exists in four immunogenically distinct and genetically-related serotypes (DENV-1 to 4), each subdivided in genotypes. Despite the endemicity of all four DENV serotypes in Thailand, no prior study has characterized the circulation of DENV in the southern provinces of the country. To determine the genetic diversity of DENV circulating in Southern Thailand in 2015 and 2016, we investigated 46 viruses from 182 patients’ sera confirmed positive for DENV by serological and Nested RT-PCR tests. Our dataset included 2 DENV-1, 20 DENV-2, 9 DENV-3 and 15 DENV-4. Phylogenetic analysis was performed on viral envelop sequences. This revealed that part of the identified genotypes from DENV-1 and DENV-4 had been predominant in Asia (genotype I for both serotypes), while genotype II for DENV-4 and the Cosmopolitan genotype DENV-2 were also circulating. Whereas DENV-3 genotype II had been predominantly detected in South East Asia during the previous decades, we found genotype III and genotype I in Southern Thailand. All DENV genotype identified in this study were closely related to contemporary strains circulating in Southeast Asian countries, emphasizing the regional circulation of DENV. These results provide new insights into the co-circulation of all four DENV serotypes in Southern Thailand, confirming the hyperendemicity of DENV in the region. These findings also suggest a new trend of dissemination for some DENV serotypes with a possible shift in genotype distribution; as recently observed in other Asian countries.

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Section: Introductionmentioning

confidence: 99%

Phylogenetic analysis revealed the co-circulation of four dengue virus serotypes in Southern Thailand

et al. 2019

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“…The reasons for this spatial concentration of cases in these eastern districts is PLOS NEGLECTED TROPICAL DISEASES unknown. It is possible that the increase in severe cases in these areas followed a serotype switch from DENV 4 to DENV 1 reported to have occurred in Sandakan between 2013 and 2016 [26]. Major dengue outbreaks commonly follow the switching of DENV serotypes and the subsequent loss of herd immunity in the human population.…”

Section: Severe Denguementioning

confidence: 99%

“…Mosquito breeding and human movement facilitate the ongoing circulation of all four human DENV serotypes across the country, although circulation patterns are distinct between states [22,23]. In addition, sylvatic DENV serotypes detected from human cases on the island of Borneo suggest a greater diversity of viruses in some habitats [24][25][26] and the potential for sylvatic viruses to enter human transmission cycles [27].…”

Section: Introductionmentioning

confidence: 99%

“…Increased incidence rates of P. knowlesi malaria in Sabah have been linked to deforestation and land use changes, which lead to increased contact between its Anopheline vectors, primate hosts and humans [31,32]. Given the marked environmental change occurring in Sabah, and the increase in dengue cases noted in recent years [15,26], it is essential from a public health perspective to understand current disease patterns and their associated risk factors. Our study describes recent spatial and temporal trends in dengue incidence, and some potential demographic and entomological risk factors from this understudied region of South East Asia.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and epidemiological features of dengue in Sabah, Malaysia

et al. 2020

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In South East Asia, dengue epidemics have increased in size and geographical distribution in recent years. We examined the spatiotemporal distribution and epidemiological characteristics of reported dengue cases in the predominantly rural state of Sabah, in Malaysian Borneo-an area where sylvatic and urban circulation of pathogens are known to intersect. Using a public health data set of routinely notified dengue cases in Sabah between 2010 and 2016, we described demographic and entomological risk factors, both before and after a 2014 change in the clinical case definition for the disease. Annual dengue incidence rates were spatially variable over the 7-year study period from 2010-2016 (state-wide mean annual incidence of 21 cases/100,000 people; range 5-42/100,000), but were highest in rural localities in the western districts of the state (Kuala Penyu, Nabawan, Tenom and Kota Marudu). Eastern districts exhibited lower overall dengue rates, although a high proportion of severe (haemorrhagic) dengue cases (44%) were focused in Sandakan and Tawau. Dengue incidence was highest for those aged between 10 and 29 years (24/100,000), and was slightly higher for males compared to females. Available vector surveillance data indicated that during large outbreaks in 2015 and 2016 the mosquito Aedes albopictus was more prevalent in both urban and rural households (House Index of 64%) than Ae. aegypti (15%). Demographic patterns remained unchanged both before and after the dengue case definition was changed; however, in the years following the change, reported case numbers increased substantially. Overall, these findings suggest that dengue outbreaks in Sabah are increasing in both urban and rural settings. Future studies to better understand the drivers of risk in specific age groups, genders and geographic locations, and to test the potential role of Ae. albopictus in transmission, may help target dengue prevention and control efforts.

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“…The emergence of DENV-4 genotype IIa in Malaysia was reported for the first time in 2001 [4]. This serotype was also documented in East Malaysia (Sandakan) in 2016 [5]. However, no further genomic characterization is currently available.…”

Section: Introductionmentioning

confidence: 99%

Resurgence of Dengue Virus Serotype 4 in Malaysia: A Comprehensive Clinicodemographic and Genomic Analysis

Suppiah,

Ali,

Mohd Khalid

et al. 2023

TropicalMed

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Dengue virus serotype 4 (DENV-4) has been the rarest circulating serotype in Malaysia, resulting in it being an understudied area. A recent observation from institutional surveillance data indicated a rapid increase in DENV-4-infected cases. The present study aimed to investigate the resurgence of DENV-4 in relation to the demographic, clinical and genomic profiles of 75 retrospective dengue samples. First, the demographic and clinical profiles obtained between 2017 and July 2022 were statistically assessed. Samples with good quality were subjected to full genome sequencing on the Illumina Next Seq 500 platform and the genome data were analysed for the presence of mutations. The effect of the mutations of interest was studied via an in silico computational approach using SWISS-MODEL and AlphaFold2 programs. The predominance of DENV-4 was discovered from 2021 to 2022, with a prevalence of 64.3% (n = 9/14) and 89.2% (n = 33/37), respectively. Two clades with a genetic divergence of 2.8% were observed within the dominant genotype IIa. The majority of DENV-4-infected patients presented with gastrointestinal symptoms, such as vomiting (46.7%), persistent diarrhoea (30.7%) and abdominal pain (13.3%). Two mutations, His50Tyr and Pro144Ser, located at the wing domain of the NS1 protein were discovered to be unique to the recently sequenced DENV-4.

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Circulation of all dengue virus serotypes during dengue outbreak in Sandakan, Sabah, Malaysia (2016)

Cited by 11 publications

References 5 publications

Phylogenetic analysis revealed the co-circulation of four dengue virus serotypes in Southern Thailand

Phylogenetic analysis revealed the co-circulation of four dengue virus serotypes in Southern Thailand

Incidence and epidemiological features of dengue in Sabah, Malaysia

Resurgence of Dengue Virus Serotype 4 in Malaysia: A Comprehensive Clinicodemographic and Genomic Analysis

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