Circulation levels of acute phase proteins in patients with Takayasu arteritis

Ma, Jun; Luo, Xiaoyun; Wu, Qinghua; Chen, Zhong; Kou, Lei; Wang, Haitao

doi:10.1016/j.jvs.2009.09.038

Cited by 31 publications

(28 citation statements)

References 25 publications

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“…SAA is elevated in adults with both Takayasu arteritis and giant cell arteritis, and correlates with disease activity of inflammatory arteriopathies. 26, 27 …”

Section: Discussionmentioning

confidence: 99%

Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke

Fullerton

deVeber

Hills

et al. 2016

Stroke

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Background and Purpose Among children with arterial ischemic stroke (AIS), those with arteriopathy have the highest recurrence risk. We hypothesized that arteriopathy progression is an inflammatory process, and that inflammatory biomarkers would predict recurrent AIS. Methods In an international study of childhood AIS, we selected cases classified into one of the three most common childhood AIS etiologies: definite arteriopathic (N=103), cardioembolic (N=55), or idiopathic (N=78). We measured serum concentrations of high sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), myeloperoxidase (MPO), and tumor necrosis factor alpha (TNF-α). We used linear regression to compare analyte concentrations across the subtypes, and Cox proportional hazards models to determine predictors of recurrent AIS. Results Median age at index stroke was 8.2 years (IQR 3.6, 14.3); serum samples were collected at median 5.5 days post-stroke (IQR 3, 10 days). In adjusted models (including age, infarct volume, and time to sample collection) with idiopathic as the reference, the cardioembolic (but not arteriopathic) group had higher concentrations of hsCRP and MPO, while both cardioembolic and arteriopathic groups had higher SAA. In the arteriopathic (but not cardioembolic) group, higher hsCRP and SAA predicted recurrent AIS. Children with progressive arteriopathies on follow-up imaging had higher recurrence rates, and a trend towards higher hsCRP and SAA, compared to children with stable or improved arteriopathies. Conclusion Among children with AIS, specific inflammatory biomarkers correlate with etiology and—in the arteriopathy group—risk of stroke recurrence. Interventions targeting inflammation should be considered for pediatric secondary stroke prevention trials.

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“…SAA is elevated in adults with both Takayasu arteritis and giant cell arteritis, and correlates with disease activity of inflammatory arteriopathies. 26, 27 …”

Section: Discussionmentioning

confidence: 99%

Inflammatory Biomarkers in Childhood Arterial Ischemic Stroke

Fullerton

deVeber

Hills

et al. 2016

Stroke

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show abstract

“…In addition to ESR or serum CRP levels, various other serologic markers, including serum cytokines, matrix metalloproteinases, and serum amyloid A, have been reported to be biologic markers of active TA. [21][22][23] In current clinical practice, no single marker accurately reflects the activity of TA. An autopsy study from India reported that TA disease activity persists for a long time, even in the absence of clinical or laboratory examinations.…”

Section: Discussionmentioning

confidence: 99%

Surgical bypass vs endovascular treatment for patients with supra-aortic arterial occlusive disease due to Takayasu arteritis

Kim

Park

et al. 2012

Journal of Vascular Surgery

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“…In advanced studies, we first evaluated circulation levels of acute phase proteins in TA patients and defined their possibility as biomarkers for activity judgment in this disease. 18 It is also suggested that humoral immunity functional disorder exists in TA patients. Various studies have indicated that TA had a tight relationship with autoimmunity mechanism.…”

Section: Discussionmentioning

confidence: 99%