Circulating α-Klotho Levels in Hemodialysis Patients and Their Relationship to Atherosclerosis

Yu, Ling; Li, Kang; Ren, Xiao-Zhuan; Diao, Zongli; Liu, Wenhu

doi:10.1159/000492245

Cited by 22 publications

(17 citation statements)

References 30 publications

(38 reference statements)

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“…This assay detects circulating s-Klotho by using two monoclonal antibodies that specifically recognize the extracellular domain of Klotho [12]. Means ± standard deviation (SD) were 6.5 ± 3.3% for inter-assay and 3.6 ± 1.5% for intra-assay coefficients of variability [13]. …”

Section: Methodsmentioning

confidence: 99%

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Zhang

Guo

et al. 2019

Kidney Blood Press Res

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Background: Cardiovascular disease is the leading cause of morbidity and mortality in maintenance hemodialysis (MHD) patients. Uremic cardiomyopathy, characterized by myocardial hypertrophy and fibrosis, has a significant contribution to these adverse cardiac outcomes. The protective effect of soluble Klotho (s-Klotho) on myocardial damage was demonstrated in in vitro and animal experiments. However, data from MHD patients is limited. The present study was designed to identify potential correlations between echocardiographic parameters and serum s-Klotho levels in MHD patients. Methods: This is a cross-sectional study involving 105 MHD patients from the Dialysis Center of Capital Medical University affiliated Beijing Friendship Hospital between March and October 2014. The general information for each patient was recorded. Fasting blood samples were collected prior to hemodialysis during the mid-week session in all patients. The echocardiogram and left lateral lumbar spine radiograph were performed after the same mid-week session. The dialysis records for each session within 3 months before the blood tests were documented. According to the quartiles of s-Klotho levels, patients were divided into four groups (Group 1–4). The demographic and clinical characteristics, echocardiographic parameters, and abdominal aortic calcification scores among the groups were compared. Results: The enrolled 105 patients were predominantly male (54.3%) with an average age of 59.9 ± 11.2 years. Previous hemodialysis durations were 76 (42–133) months. Sixteen (15.2%) patients had diabetes mellitus. Mean serum s-Klotho level was 411.83 ± 152.95 pg/mL, and the 25th percentile, 50th percentile, and 75th percentile values of serum s-Klotho levels were 298.9, 412, and 498.2 pg/mL, respectively. Individuals in the bottom quartile of s-Klotho levels (Group 1) had significantly increased interventricular septal thickness (IVST) compared to those in the other three quartiles of s-Klotho levels (Group 1: 1.12 ± 0.16 cm; vs. Group 2: 1.12 ± 0.16 cm, p = 0.008; vs. Group 3: 0.94 ± 0.13 cm, p < 0.001; vs. Group 4: 1.03 ± 0.1 5 cm, p = 0.022). There were significant differences in the ratios of IVST and posterior wall thickness (PWT) between patients of Group 1 and Group 3 (1.12 ± 0.1 2 vs. 1.00 ± 0.1 4, p = 0.004). No significant differences were found for other parameters among the groups. The univariate correlation analyses showed that gender (r = –0.211, p = 0.030), Kt/V urea (r = –0.240, p = 0.014), hypersensitive C reactive protein (hs-CRP) (r = 0.196, p = 0.045), and serum s-Klotho levels (r = –0.260, p = 0.007) significantly correlated with IVST. Ultimately, only hs-CRP and serum s-Klotho levels were entered into a multiple regression model. Conclusions: The present study showed that patients with lower circulating s-Klotho levels were more often associated with larger IVST and greater ratios of IVST and PWT. There was an independent association between s-Klotho and IVST, and lower s-Klotho levels seem to be a potential risk factor of uremic...

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Section: Methodsmentioning

confidence: 99%

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Zhang

Guo

et al. 2019

Kidney Blood Press Res

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“…Aging is associated with a reduction in the renal expression and serum concentrations of Klotho, which is also observed in diseases characterized by premature vascular aging, such as renal failure, hypertension, and diabetes mellitus [4][5][6]. Moreover, several clinical studies have observed that lower systemic levels of the soluble form of Klotho are associated with markers of vascular dysfunction [7][8][9][10] as well as with the prevalence and severity of cardiovascular disease (CVD) [11][12][13]. These associations are particularly relevant in renal patients since the largest proportion of systemic Klotho is generated by the kidneys and its levels are reduced along with the renal function decline [14].…”

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confidence: 98%

Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study

Martín‐Núñez

Donate‐Correa

Ferri

et al. 2020

Aging

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INTRODUCTION Klotho (KL) is a longevity-related gene discovered in 1997 [1]. Defects in KL expression leads to a syndrome resembling human aging that includes endothelial dysfunction, vascular calcification and progressive atherosclerosis [1]. KL gene encodes a single-pass transmembrane glycoprotein type 1, mainly expressed in renal tubular cells, and a soluble form derived from the action of membrane proteases that cleave the extracellular domain of the membranebound protein [2, 3].

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“…Atherosclerosis often results in cardiovascular events (CVD), the most severe complication and a significant cause of mortality in patients on MHD 23 . We found some factors, which could predict atherosclerosis in MHD patients, such as duration of hemodialysis, serum PTH, and OPG levels.…”

Section: Discussionmentioning

confidence: 84%

Serum osteoprotegerin level in hemodialysis patients using low‐flux reused dialyzer in relation to atherosclerosis

Van

Minh²,

Quy³

et al. 2021

Clinical Laboratory Analysis

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Aims To assess the relation of high serum OPG level and carotid atherosclerosis in maintenance hemodialysis (MHD) patients using low‐flux reused dialyzer. Materials and Methods We examined 209 MHD patients with and without carotid atherosclerosis (83 patients and 126 patients) to establish the relation between OPG and atherosclerosis. Results The proportion of carotid atherosclerosis was 39.7%. The median serum OPG level was 45.3 pmol/L. Serum OPG had a good predicting value for atherosclerosis in MHD patients using low‐flux reused dialyzer (AUC = 0.934, p < 0.001, cutoff value = 43.35 pmol/L, Se = 81.3%, Sp = 90.9%). Conclusions In this study, serum OPG had a good predicting value for atherosclerosis in MHD patients using low‐flux reused dialyzer.

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Circulating α-Klotho Levels in Hemodialysis Patients and Their Relationship to Atherosclerosis

Cited by 22 publications

References 30 publications

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study

Serum osteoprotegerin level in hemodialysis patients using low‐flux reused dialyzer in relation to atherosclerosis

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