Circulating Vascular Endothelial Growth Factor-1 in Cardiovascular Disease

Berezin, Alexander E.

doi:10.1007/978-94-007-7741-5_2-1

Cited by 2 publications

References 66 publications

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Promising Role of Vascular Endothelial Growth Factor-A in Risk Stratification after PCI

Petyunina¹,

Kopytsya²,

Rudyk³

et al. 2019

Vascular Access Surgery - Tips and Tricks

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Vascular endothelial growth factor-A (VEGF-A), dimeric glycoprotein, is a potent endothelial cell-specific mitogen which plays a key role in angiogenesis, especially in response to ischemia. Biomarkers reflect various pathophysiological faces of spherical LV transformation that related to myocardial stress due to persisted ischemia, fibrosis, and inflammation, and they may be helpful to improve risk stratification, more personalized medical approach for creating of individual medical care for HF preventing and adjusted treatment after STEMI. VEGF-A decrease ≤172.4 pg./ ml on the 7th day of STEMI allows to prognose after infarction angina after 6-month observation (area under curve (AUC) 0.697, with sensitivity 88.9% and specificity 50.9%; 95% CI 0.567-0.807, P = 0.0515). Anxiety and depression 10-14 days before MI associated with VEGF-A level decrease (anxiety (Taylor): OR 0.834, 95% CІ 0.726-0.959, Р = 0.0107; depression (HADS): OR 0.741, 95% CІ 0.535-1.027, Р = 0.0519. Cutoff VEGF-A level ≤201.86 pg./ml on the 7th day of STEMI (AUC 0.711, sensitivity 85.7% and specificity 57.9%; 95% CІ 0.513-0.908, Р = 0.036) was effective for prognosis of dysadaptive left ventricular remodeling in STEMI patients after 6-month observation period. These findings may open new approach to stratify patients with successful coronary revascularization at risk of HF.

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Promising Role of Vascular Endothelial Growth Factor-A in Risk Stratification after PCI

Petyunina¹,

Kopytsya²,

Rudyk³

et al. 2019

Vascular Access Surgery - Tips and Tricks

View full text Add to dashboard Cite

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Is the neutrophil extracellular trap-driven microvascular inflammation essential for diabetes vasculopathy?

Berezin

2016

Biomed Res Ther

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Abstract-The neutrophil extracellular traps (NETs) are defined as an extensive web consisting decondensed chromatin, which is released from activated neutrophils, as well as cytotoxic proteins, histones and microbicidal proteases that cause tissue damage. NETs contribute to endothelial damage, inflammation, thrombosis, platelet aggregation, ischemia, that are essential players in the pathobiology of diabetic complications. The objective of the review is to highlight the possible role of NETosis in early diabetes-related vasculopathy beyond cardiovascular complications. Although the clinical significance of NETosis in diabetes beyond early atherosclerosis and cardiovascular complications is not still clear, there is limited data with respect to useful to use biological markers of NETosis aimed early stratification of the diabetics at risk of disease progression. Furthermore, several inductors of NETosis might be a target for novel pharmacological approaches to delay advance in diabetes and prevent diabetes-related vasculopathy.

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Circulating Vascular Endothelial Growth Factor-1 in Cardiovascular Disease

Cited by 2 publications

References 66 publications

Promising Role of Vascular Endothelial Growth Factor-A in Risk Stratification after PCI

Promising Role of Vascular Endothelial Growth Factor-A in Risk Stratification after PCI

Is the neutrophil extracellular trap-driven microvascular inflammation essential for diabetes vasculopathy?

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