Circulating Vascular Cell Adhesion Molecules VCAM-1, ICAM-1, and E-Selectin in Dependence on Aging

Richter, V.; Rassoul, F; Purschwitz, K.; Hentschel, Bettina; Reuter, W; Kuntze, Thomas

doi:10.1159/000071710

Cited by 67 publications

(43 citation statements)

References 25 publications

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“…Unexpectedly, sVCAM values are higher in the present study than in the previous one. This can be explained because young subjects' usual diet was higher in percentage of energy supplied from fat and did not conform with the fruit and vegetable dietary recommendations compared with the postmenopausal women, as it has been suggested that sVCAM reflects diet more than sICAM [41].…”

Section: Discussionmentioning

confidence: 95%

Reduction in cardiovascular risk by sodium-bicarbonated mineral water in moderately hypercholesterolemic young adults

Pérez-Granados

Navas-Carretero

Schoppen

et al. 2010

The Journal of Nutritional Biochemistry

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Effects of drinking a sodium bicarbonated mineral water on cardiovascular risk in young men and women with moderate cardiovascular risk were studied. Eighteen young volunteers, total cholesterol levels >5.2 mmol/L without any disease participated. The study consisted in two 8-week intervention periods. Subjects consumed, as a supplement of their usual diet, 1 L/d of a control low mineral water followed by 1 L/d of the bicarbonated mineral water (mmol/L: sodium, 48; bicarbonate, 35; and chloride, 17). Determinations were performed at the end of the control water period and weeks 4 and 8 of the bicarbonated water period. Body weight, BMI, blood pressure, dietary intake, total-cholesterol, LDL-cholesterol, HDL-cholesterol, Apo A-I, Apo B, triacylgycerols, glucose, insulin, adiponectin, high sensitivity-C reactive protein (hs-CRP), soluble adhesion molecules (sICAM and sVCAM), sodium and chloride urinary excretion, and urine pH were measured. Dietary intake, body weight and BMI showed no significant variations. Systolic blood pressure decreased significantly after 4 weeks of bicarbonated water consumption without significant differences between the weeks 4 and 8.Significant reductions were observed after bicarbonated water consumption of total cholesterol (by 6.3%, p=0.012), LDL-cholesterol (by 10% p=0.001), total/HDL-cholesterol (p=0.004), LDL/HDL-cholesterol (p=0.001), and Apo B (p=0.017). Serum triacylglycerols, Apo A-I, sICAM-1, sVCAM-1 and hs-CRP levels did not change. Serum glucose values tended to decrease during the bicarbonated water intervention (p=0.056) but insulin levels did not vary. This sodium bicarbonated mineral water improves lipid profile in moderately hypercholesterolemic young men and women and could therefore be applied in dietary interventions to reduce cardiovascular risk.3

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Section: Discussionmentioning

confidence: 95%

Reduction in cardiovascular risk by sodium-bicarbonated mineral water in moderately hypercholesterolemic young adults

Pérez-Granados

Navas-Carretero

Schoppen

et al. 2010

The Journal of Nutritional Biochemistry

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“…Surprisingly, increased VCAM-1 expression in the aortic wall with age was not accompanied by an increase in aortic lesions. Studies of human populations also show that circulating VCAM-1 is an age-dependent parameter independent of cardiovascular risk [25]. …”

Section: Discussionmentioning

confidence: 99%

Effect of Aging on Fatty Streak Formation in a Diet-Induced Mouse Model of Atherosclerosis

Li¹,

Gilbert²,

Matsumoto³

et al. 2007

J Vasc Res

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Age is considered to be a major risk factor for atherosclerosis, but it is unclear whether age has a direct effect on susceptibility to atherosclerosis. Wild-type mice develop fatty streak lesions in the aortic root only when fed a cholate-containing high fat/cholesterol diet. To investigate the influence of age on fatty streak formation, young (10 weeks) and old (53 weeks) female C57BL/6 mice were fed an atherogenic diet containing 15% fat, 1.25% cholesterol and 0.5% sodium cholate for 12 weeks. Atherosclerotic lesions at the aortic root were measured after cryosections were stained with oil red O. Results showed that old mice developed a comparable size of aortic lesions with young counterparts (5,600 ± 2,480 vs. 6,457 ± 1,537 µm²/section; p = 0.77), although old mice had significantly higher plasma cholesterol levels than young mice on the atherogenic diet (p < 0.05). Plasma levels of soluble vascular cell adhesion molecule 1 were significantly higher in old mice than in young mice on both chow and Western diets (p < 0.005). These data indicate that age has no direct effect on atherosclerosis susceptibility although it is accompanied by elevations in plasma cholesterol and vascular cell adhesion molecule 1 levels in C57BL/6 mice. Thus, increased cardiovascular events with age are probably related to a progressive increase in plaque size rather than to an increase in atherosclerosis susceptibility.

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“…Activated endothelial cells elaborate adhesion molecules, cytokines and chemokines, enzymes that synthesize vasoactive molecules (e.g., cyclooxygenase-[COX-]2 and iNOS) and a variety of other gene products. Importantly, phenotypic changes characteristic to endothelial activation (e.g., induction of adhesion molecules, chemokines) have been demonstrated in aging [39][40][41][42]. Also, upregulation of iNOS is present in coronary arteries [18], aorta [23], kidney [43] and other vascular tissues [44] of aged rats.…”

Section: Upregulation Of Vascular Expression Of Inos Cox-2 Chemokinmentioning

confidence: 99%

Vascular Inflammation in Aging

Ungvári¹,

Csiszár²,

Kaley

2004

Herz

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Although epidemiologic studies have revealed that high plasma cholesterol or high homocysteine levels, as well as diabetes, hypertension and smoking are important risk factors for atherosclerotic vascular disease, the deleterious effects of these conditions can be delayed or significantly attenuated by therapeutic interventions. Since the population in the Western world is aging, advancing age itself became one of the most significant risk factors for the development of atherosclerosis. Atherosclerosis is a chronic inflammatory disease, however, the mechanisms by which advanced age per se promotes vascular inflammation are not well understood. In the present review the authors propose a model for age-related alterations in cytokine expression, increased oxidative stress and decreased bioavailability of NO that underlie a pro-inflammatory phenotype of aged vessels promoting the development of atherosclerosis in the elderly.

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Circulating Vascular Cell Adhesion Molecules VCAM-1, ICAM-1, and E-Selectin in Dependence on Aging

Cited by 67 publications

References 25 publications

Reduction in cardiovascular risk by sodium-bicarbonated mineral water in moderately hypercholesterolemic young adults

Reduction in cardiovascular risk by sodium-bicarbonated mineral water in moderately hypercholesterolemic young adults

Effect of Aging on Fatty Streak Formation in a Diet-Induced Mouse Model of Atherosclerosis

Vascular Inflammation in Aging

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