Circulating Urine Phthalates Are not Associated with a Decline in Cognition in Adults and the Elderly: NHANES, 1999–2002

Shiue, Ivy; Starr, John M.

doi:10.1159/000341535

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…more details via http://wwwn.cdc.gov/nchs/nhanes/2001-2002/HOQ_B.htm), self-reported chronic diseases (question: Has a doctor or other health professionals ever told you that you have X disease? more details via http://wwwn.cdc.gov/nchs/nhanes/2001-2002/MCQ_B.htm) and cognitive function (the digit symbol substitution test from the Wechsler Adult Intelligence Scale, a measure of attention and psychomotor speed, DSS) was obtained by a household interview (The Psychological Corporation 1997; more details via http://wwwn.cdc.gov/nchs/nhanes/2001-2002/CFQ_B.htm), which has been widely used and subsequently published (Shiue and Starr 2012). …”

Section: Methodsmentioning

confidence: 99%

Short residence duration was associated with asthma but not cognitive function in the elderly: USA NHANES, 2001–2002

Shiue

2016

Environ Sci Pollut Res

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There has been a growing interest in how the built environment affects health and well-being. Housing characteristics are associated with human health while environmental chemicals could have mediated the effects. However, it is unclear if and how residence duration might have a role in health and well-being. Therefore, the aim of the present study was to investigate the associations among residence duration, common chronic diseases, and cognitive function in older adults in a national and population-based setting. Data were extracted from the US National Health and Nutrition Examination Survey, 2001–2002, with assessment information on demographics, lifestyle factors, housing characteristics, self-reported common chronic diseases, and cognitive function by using the digit symbol substitution test from the Wechsler Adult Intelligence Scale (a measurement of attention and psychomotor speed). Statistical analyses including the chi-square test, t test, and survey-weighted general linear modeling and logistic regression modeling were performed. Residence duration was significantly associated with risk of asthma but not with other chronic disease, showing a longer stay in the same housing leading to lower risk of asthma (OR 0.43, 95%CI 0.27–0.69, P = 0.002) among the American older adults. However, having asthma was not associated with cognitive function decline. In conclusion, residence duration was found to be associated with risk of asthma but not cognitive function. Future research examining the relationship of residence duration and cognitive tests by other domains of cognitive function following asthma episodes would be suggested. For practice and policy implications, familiarity with the housing environment might help with lessening respiratory symptoms.

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Section: Methodsmentioning

confidence: 99%

Short residence duration was associated with asthma but not cognitive function in the elderly: USA NHANES, 2001–2002

Shiue

2016

Environ Sci Pollut Res

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“…However, regarding cognitive impairment, studies have mainly focused on the deleterious effects of phthalates on neurodevelopment in children, and human data in adults are rather limited (Radke et al, 2020). To date, only three epidemiological studies have explored the association between phthalates and cognitive function among elderly adults, and their ndings are inconsistent (Shiue, 2015;Shiue and Starr, 2012;Weng et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice

Wang

Dong

et al. 2023

Environ Sci Pollut Res

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Phthalates are a group of neurotoxicants with cognitive-disrupting potentials. Given the structural diversity of phthalates, the corresponding neurotoxicity is dramatically altered. To identify the potential contributions of different phthalates on the process of cognitive impairment, data of 836 elders from the NHANES 2011-2014 cycles were used. Survey-weighted logistic regression and principal component analysis-weighted quantile sum regression (PCA-WQSR) models were applied to estimate the independent and combined associations of 11 urinary phthalate metabolites with cognitive de cit [assessed by 4 tests: Immediate Recall (IR), Delayed Recall (DR), Animal Fluency (AF), and Digit Symbol Substitution test (DSST] and to identify the potential phthalate with high weight. Laboratory mice were further used to examine the effect of phthalates on cognitive function and to explore the potential mechanisms. In logistic regression models, MBzP was the only metabolite positively correlated with four tests, with ORs of 2.53 [quartile 3 (Q3)], 2.26 (Q3), 2.89 (Q4) and 2.45 (Q2), 2.82 (Q4) for IR, DR, AF and DSST respectively. In PCA-WQSR co-exposure models, low-molecular-weight (LMW) phthalates were the only PC positively linked to DSST de cit (OR: 1.93), which was further validated in WQSR analysis (WQS OR 7 − phthalates : 1.56 and WQS OR 8 − phthalates : 1.55); consistent with the results of logistic regression, MBzP was the dominant phthalate. In mice, butyl benzyl phthalate (BBP), the parent phthalate of MBzP, dose-dependently reduced cognitive function and disrupted hippocampal neurons. Additionally, the hippocampal transcriptome analysis identi ed 431 differential expression genes, among which most were involved in inhibiting the neuroactive ligand-receptor interaction pathway and activating the cytokine-cytokine receptor interaction pathway. Our study indicates the critical role of BBP in the association of phthalates and cognitive de cits among elderly individuals, which might be speculated that BBP could disrupt hippocampal neurons, activate neuroin ammation and inhibit neuroactive receptors. Our ndings provide new insight into the cognitive-disrupting potential of BBP.

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Association between mixed exposure of phthalates and cognitive function among the U.S. elderly from NHANES 2011–2014: Three statistical models

Weng

Tan

Fei

et al. 2022

Science of The Total Environment

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Circulating Urine Phthalates Are not Associated with a Decline in Cognition in Adults and the Elderly: NHANES, 1999–2002

Cited by 4 publications

References 14 publications

Short residence duration was associated with asthma but not cognitive function in the elderly: USA NHANES, 2001–2002

Short residence duration was associated with asthma but not cognitive function in the elderly: USA NHANES, 2001–2002

Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice

Association between mixed exposure of phthalates and cognitive function among the U.S. elderly from NHANES 2011–2014: Three statistical models

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