Circulating tumour cells in head and neck cancers: Biological insights

Rao, Vishal; Arakeri, Gururaj; Subash, Anand; Bagadia, Ritvi K.; Thakur, S.; Kudpaje, Akshay; Nayar, Ravi; Patil, Shekar; Fonseca, Felipe Paiva; Gomez, Ricardo Santiago; Brennan, Peter A.

doi:10.1111/jop.13075

Cited by 4 publications

(2 citation statements)

References 58 publications

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“…In HNSCC, investigation of CTCs and ctDNA in different disease or treatment status has been considered as a predictive marker for diagnosis, prognosis and response to treatment [ 55 , 109 , 110 , 114 , 117 , 118 , 119 ]. Additionally, positive CTCs after major treatment are associated with an increased risk of distal metastasis in patients with localized HNSCC [ 120 , 121 ].…”

Section: Circulating Tumor Cells (Ctcs) and Circulating Tumor Dnamentioning

confidence: 99%

Exploration of Feasible Immune Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Treatment in Real World Clinical Practice

Wang

Yeh

Chan

et al. 2020

IJMS

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Recurrent locally advanced or metastatic head and neck squamous cell carcinoma (HNSCC) is associated with dismal prognosis because of its highly invasive behavior and resistance to conventional intensive chemotherapy. The combination of targeted therapy and conventional chemotherapy has significantly improved clinical outcomes. In recent years, the development of immunotherapies, such as immune checkpoint inhibitors (ICIs), has further increased treatment responses and prolonged survival. However, the limited response rate, risk of immunotherapy-related adverse effects and high cost of immunotherapy make the identification of predictive markers to optimize treatment efficacy a critical issue. Biomarkers are biological molecules that have been widely utilized to predict treatment response to certain treatments and clinical outcomes or to detect disease. An ideal biomarker should exhibit good predictive ability, which can guide healthcare professionals to achieve optimal treatment goals and bring clinical benefit to patients. In this review, we summarized the results of recent and important studies focused on HNSCC ICI immunotherapy and discussed potential biomarkers including their strengths and limitations, aiming to gain more insight into HNSCC immunotherapy in real world clinical practice.

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Section: Circulating Tumor Cells (Ctcs) and Circulating Tumor Dnamentioning

confidence: 99%

Exploration of Feasible Immune Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Treatment in Real World Clinical Practice

Wang

Yeh

Chan

et al. 2020

IJMS

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“…Circulating tumor cells have been implicated in loco-regional and distant metastasis and their role is head and neck region 1 is found but lack of evidence in tongue tumor. PDL-1 can represent the immune status of the patients and it is found to be a good biomarker 2 .…”

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confidence: 99%

Evaluation of premetastatic changes in lymph nodes(pN0) of oral tongue tumour: A prospective observational Study

Geetha

Pavithran

et al. 2023

F1000Res

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Background: Tongue tumors show intra and inter-tumoral heterogenicity with high incidence, relapse and mortality rates necessitating further research. Recurrence/metastasis that occurs after surgical resection of primary cancer is often the reason for poor survival in these patients. Lymph nodes are the most common site of metastasis in tongue tumors. Therefore, premetastatic molecular changes can be best evaluated in lymph nodes which may epitomize the earliest events in the metastasis cascades. The presence of circulating tumor cells(CTCs) in the absence of nodal disease (N0) may represent tumor aggressiveness, suggesting an immune escape which may have high metastatic potential. This trial was developed to investigate the earliest pre-metastatic changes which may regulate tumor dormancy and predict metastasis. A better understanding of organotropism or pre-metastatic changes can help in theragnostic, thereby preventing the outbreak of overt metastasis. Methods: A single-institutional prospective observational cohort study. This trial will be conducted at a tertiary care Centre (Amrita Institute of Medical Sciences Kochi). Eligible patients will be enrolled after obtaining informed consent. The dissected lymph nodes will be subjected to histopathological and immunohistochemical analyses for premetastatic niche (PMN) formation. In addition, circulating tumor cells will be evaluated before treatment and 6 months after treatment. The patients will be followed up for a period of two years to correlate the findings with the recurrence-free survival. Expected results: The pre-metastatic changes, if detected will be a predictive biomarker. It may help to define future drug targets for metastasis chemoprevention . CTCs may define the tumor aggressiveness ,there by prognostication and helps in better disease management. Ethics and dissemination: The study has received the following approval: Ethics Committee of Amrita School of Medicine (ECASM-AIMS-2022-048).Trial Registered Prospectively( CTRI/2022/03/041256 ) on 22/03/2022 under Clinical Trial Registry of India

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Reply: Nodal yield and topography of nodal metastases from oral cavity squamous cell carcinoma – An audit of 1004 cases undergoing primary surgical resection

Joy

Rao

2021

Oral Oncology

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Circulating tumour cells in head and neck cancers: Biological insights

Cited by 4 publications

References 58 publications

Exploration of Feasible Immune Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Treatment in Real World Clinical Practice

Exploration of Feasible Immune Biomarkers for Immune Checkpoint Inhibitors in Head and Neck Squamous Cell Carcinoma Treatment in Real World Clinical Practice

Evaluation of premetastatic changes in lymph nodes(pN0) of oral tongue tumour: A prospective observational Study

Reply: Nodal yield and topography of nodal metastases from oral cavity squamous cell carcinoma – An audit of 1004 cases undergoing primary surgical resection

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