Circulating Tumor DNA Dynamics as Prognostic Markers in Locally Advanced and Metastatic Esophageal Squamous Cell Carcinoma
Hoi Yan Ng,
Josephine Mun Yee Ko,
Ka On Lam
et al.
Abstract:ImportanceEsophageal squamous cell carcinoma (ESCC) is a deadly disease with frequent recurrence. There are unmet needs for prognostic biomarkers for dynamically monitoring disease progression and detecting minimal residual disease.ObjectiveTo examine whether circulating tumor DNA is clinically useful as a prognostic biomarker for ESCC recurrence and patient survival.Design, Setting, and ParticipantsThis single-center, population-based cohort study consecutively enrolled 147 patients receiving curative (n = 74… Show more
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