Circulating Tumor Cell Enrichment Technologies

Boya, Mert; Chu, Chia‐Heng; Ozkaya‐Ahmadov, Tevhide; Sarioglu, A. Fatih

doi:10.1007/978-3-030-26439-0_2

Cited by 17 publications

(27 citation statements)

References 146 publications

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“…The basic principle is that cell movement is caused by sound pressure waves generated by the transducer. The standing acoustic wave in the microfluidic channel has nodes and antinodes, cells flowing through these periodic pressure nodes and antinodes are subjected to different acoustic radiation forces, the force is proportional to the cell size, resulting in the difference in lateral displacement, and then realizes the separation of CTC [87,88]. Acoustophoresis-based CTC separation has the following advantages: it separates cells in a label-free, contact-free, and biocompatible manner, and retains cells' original state, integrity, and function [21].…”

Section: Methods Based On Physical Propertiesmentioning

confidence: 99%

Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Han

Sun

et al. 2020

Sensors

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Circulating tumor cells (CTCs) are tumor cells that escaped from the primary tumor or the metastasis into the blood and they play a major role in the initiation of metastasis and tumor recurrence. Thus, it is widely accepted that CTC is the main target of liquid biopsy. In the past few decades, the separation of CTC based on the electrochemical method has attracted widespread attention due to its convenience, rapidness, low cost, high sensitivity, and no need for complex instruments and equipment. At present, CTC detection is not widely used in the clinic due to various reasons. Point-of-care CTC detection provides us with a possibility, which is sensitive, fast, cheap, and easy to operate. More importantly, the testing instrument is small and portable, and the testing does not require specialized laboratories and specialized clinical examiners. In this review, we summarized the latest developments in the electrochemical-based CTC detection and point-of-care CTC detection, and discussed the challenges and possible trends.

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Section: Methods Based On Physical Propertiesmentioning

confidence: 99%

Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Han

Sun

et al. 2020

Sensors

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“…Other methods of CTC isolation are label-free techniques utilizing filtration and fluid dynamics based on tumor cells size and deformability and not on epithelial marker detection. Different CTC collection and isolation techniques have been extensively reviewed, and thus will not be discussed here (reviewed in [48][49][50][51][52][53][54]). However, it is important to recognize that all studies discussed in this review did not use the same CTC isolation method and any incompatible results may be attributed to different CTC isolation approaches, and a component of variability is likely due to differences in detection method.…”

Section: Mechanisms For Tumor Cells To Enter the Vasculaturementioning

confidence: 99%

Gauging the Impact of Cancer Treatment Modalities on Circulating Tumor Cells (CTCs)

Mathias

Chang

Martin

et al. 2020

Cancers

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The metastatic cascade consists of multiple complex steps, but the belief that it is a linear process is diminishing. In order to metastasize, cells must enter the blood vessels or body cavities (depending on the cancer type) via active or passive mechanisms. Once in the bloodstream and/or lymphatics, these cancer cells are now termed circulating tumor cells (CTCs). CTC numbers as well as CTC clusters have been used as a prognostic marker with higher numbers of CTCs and/or CTC clusters correlating with an unfavorable prognosis. However, we have very limited knowledge about CTC biology, including which of these cells are ultimately responsible for overt metastatic growth, but due to the fact that higher numbers of CTCs correlate with a worse prognosis; it would seem appropriate to either limit CTCs and/or their dissemination. Here, we will discuss the different cancer treatments which may inadvertently promote the mobilization of CTCs and potential CTC therapies to decrease metastasis.

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“…17 Some studies focus on detecting cell clusters, which demonstrate higher metastatic propensity, rather than single cells. 18 A few researchers have attempted gene sequencing using tumor derived DNA in blood samples. 19 Of these techniques immunoaffinity based cell capture via antibodies and aptamers is the most widely adopted.…”

Section: Introductionmentioning

confidence: 99%

“…19 Of these techniques immunoaffinity based cell capture via antibodies and aptamers is the most widely adopted. 18 Immunoaffinity techniques are capable of achieving high capture purities and efficiencies. 18 CellSearch® is such a platform and is the only technology approved by FDA to be used for the clinical analysis of liquid biopsies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tandem microfluidic chip isolation of prostate and breast cancer cells from simulated liquid biopsies using CD71 as an affinity ligand

Wickramaratne

Pappas

2020

RSC Adv.

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Circulating Tumor Cell Enrichment Technologies

Cited by 17 publications

References 146 publications

Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Gauging the Impact of Cancer Treatment Modalities on Circulating Tumor Cells (CTCs)

Tandem microfluidic chip isolation of prostate and breast cancer cells from simulated liquid biopsies using CD71 as an affinity ligand

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