Circulating TSH-binding inhibiting immunoglobulins in myasthenia gravis

Kiessling, Wolfgang; Finke, R.; Kotulla, P.; Schleusener, H.

doi:10.1530/acta.0.1010041

Cited by 27 publications

(22 citation statements)

References 22 publications

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“…However, such a dual-disease phenotype study, as informative as it may be, would be difficult to carry out due to the extremely limited number of potential patients, as approximately only one among 6840 people have MG, 63 of whom only 10-15% can be expected to have some form of AITD. [64][65] In summary, our data suggest that specific autoimmune disease genes exist, as CD40 seems to be specific for GD. Moreover, our results support the concept that a single autoimmune phenotype may have a number of different subsets, reflecting different relative contributions of a several susceptibility genes.…”

Section: Discussionmentioning

confidence: 63%

A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression

et al. 2007

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Previously, we and others have demonstrated the association of a C/T single nucleotide polymorphism (SNP), in the Kozak sequence of CD40, with Graves' disease (GD). Here, using an expanded data set of patients, we confirm the association of the CD40 SNP with GD (n ¼ 210, P ¼ 0.002, odds ratio (OR) ¼ 1.8). Subset analysis of patients with persistently elevated thyroid peroxidase (TPO) and/or thyroglobulin (Tg) antibodies (Abs), (TPO/Tg Abs), after treatment (n ¼ 126), revealed a significantly stronger association of the SNP with disease (P ¼ 5.2 Â 10 À5 , OR ¼ 2.5) than in GD patients who were thyroid antibodynegative. However, the CD40 SNP was not associated with TPO/Tg Abs in healthy individuals. Next, we tested the CD40 SNP for association with Myasthenia Gravis (MG), which, like GD is an antibody-mediated autoimmune condition. Analysis of 81 MG patients found no association of the SNP with disease. Functional studies revealed significant expression of CD40 mRNA and protein in the thyroid (target tissue in GD) but not in skeletal muscle (target tissue in MG). Combined, our genetic and tissue expression data suggest that the CD40 Kozak SNP is specific for thyroid antibody production involved in the etiology of GD. Increased thyroidal expression of CD40 driven by the SNP may contribute to this disease specificity.

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Section: Discussionmentioning

confidence: 63%

A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression

et al. 2007

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“…9,10 Graves' disease (GD) is the commonest AITD associated with MG. 9,10 Graves' disease and MG are more common in females. A higher frequency of thyroid antibodies has been observed in OMG compared to generalized myasthenia gravis (GMG).…”

Section: Introductionmentioning

confidence: 99%

Myasthenia gravis associated with autoimmune thyroid disease: A report of two patients

2008

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“…In supalized forms involving systemic skeletal muscles (1). port of this hypothesis we found that among MG patients MG is often associated with other autoimmune disorders, with associated Graves' disease (GD), there was a higher freincluding autoimmune thyroid diseases (AITD) (2)(3)(4)(5)(6)(7)(8). We quency of ocular MG in those with clinically overt TAO (9).…”

mentioning

confidence: 88%

Increased Frequency of Euthyroid Ophthalmopathy in Patients with Graves' Disease Associated with Myasthenia Gravis

Marinò¹,

Barbesino²,

Pinchera³

et al. 2000

Thyroid

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We previously showed that myasthenia gravis (MG) has a mild clinical expression when associated with autoimmune thyroid diseases (AITD). In the present study we have investigated the frequency of thyroid-associated ophthalmopathy (TAO) in patients with Graves' disease (GD) associated with MG as compared with GD patients without MG. A total of 418 patients with GD were studied, 31 with MG and 387 without MG. TAO was evaluated by physical examination, exophthalmometry, computerized tomography, and computerized visual fields assessment. The overall prevalence of TAO was similar in GD patients with MG (61.2%) and in those without MG (56.4%). When the analysis was restricted to GD patients with ocular MG, a greater frequency of TAO was found (84.6%), compared with GD patients without MG or with GD patients with generalized MG, although the differences did not reach the statistical significance. GD patients with MG had a significantly greater prevalence (12.9%) of euthyroid ophthalmopathy (clinically overt ophthalmopathy without previous and/or current hyperthyroidism) than those without MG (3.1%; p = 0.003). The results suggest a preferential association between the ocular manifestations of GD and MG, which may be due to immunological cross-reactivity against common autoimmune targets in the eye muscle as well as to a common genetic background.

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Circulating TSH-binding inhibiting immunoglobulins in myasthenia gravis

Cited by 27 publications

References 22 publications

A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression

A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression

Myasthenia gravis associated with autoimmune thyroid disease: A report of two patients

Increased Frequency of Euthyroid Ophthalmopathy in Patients with Graves' Disease Associated with Myasthenia Gravis

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