Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis

Zhang, Zhenzhen; Chen, Qiang; Kong, Chao‐Yue; Li, Zhanming; Wang, Li‐Shun

doi:10.18632/oncotarget.14251

Cited by 5 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The macro and SAS code used were included in the online, http://link.springer.com/article/10.3758/BRM.41.1.35 Statistical analyses were performed by Stata 12.0 (Stata Corporation, College Station, TX, USA) and P values of two-sided less than 0.05 were considered statistically significant. Heterogeneity among studies was assessed using I 2 statistics, which test total variation across studies [ 55 , 56 , 64 , 65 ].…”

Section: Methodsmentioning

confidence: 99%

Meta-analysis reveals gender difference in the association of liver cancer incidence and excess BMI

Yao

Ding

et al. 2017

Oncotarget

Self Cite

View full text Add to dashboard Cite

Excess body weight has a positive association with risk of liver cancer, but the gender difference in the relationship between body mass index and liver cancer risk remains uncertainty. In this work, we performed meta-analysis for excess body weight and risk of liver cancer incidence to identify the gender difference. We searched the English-languages database and the Chinese literature databases to May 12, 2017. Overall, a total of 17 studies were included. Relative risks (RRs) with 95% confidence intervals was used to evaluate the strength of these associations. The RRs of liver cancer incidence for obese men and women were 2.04 (1.70–2.44) and 1.56 (1.37–1.78). The former one was significantly higher than the later one (P for interaction = 0.02). Notably, the RR of liver cancer incidence in non-Asian obese men was even higher than their counter part (2.31(1.85–2.91) vs. 1.56 (1.31–1.86), P for interaction = 0.01). Similar gender difference was observed in the dose-response curve. As example, at the point of BMI = 32 kg/m2, the RRs for men and women were 1.61 (1.45–1.79) and 1.41 (1.02–1.94) respectively. Findings from this meta-analysis indicate that obesity is associated with a higher risk of liver cancer incidence in men, especially in non-Asian men, which might partially contribute to the male dominance of liver cancer incidence.

show abstract

Section: Methodsmentioning

confidence: 99%

Meta-analysis reveals gender difference in the association of liver cancer incidence and excess BMI

Yao

Ding

et al. 2017

Oncotarget

Self Cite

View full text Add to dashboard Cite

show abstract

“…They are mainly known for their role as ligand-dependent TFs, and the THRs bind to the thyroid hormone RE irrespective of the presence or absence of thyroid hormone to modulate the expression of target genes [ 374 ]. It was observed that the expression of THR was upregulated in thyroid cancer patients [ 375 ]. In addition, the levels of THR α 1 was also highly upregulated in human CRC patients and was found to modulate the Wnt pathway [ 128 ].…”

Section: Nuclear Receptors In Colorectal Cancermentioning

confidence: 99%

Delineating the role of nuclear receptors in colorectal cancer, a focused review

Manickasamy,

Jayaprakash,

Girisa

et al. 2024

Discov Onc

View full text Add to dashboard Cite

Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally, causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to GLOBOCAN 2020, CRC ranks third in incidence and second in mortality in both males and females. Despite extensive studies over the years, there is still a need to establish novel therapeutic targets to enhance the patients’ survival rate in CRC. Nuclear receptors (NRs) are ligand-activated transcription factors (TFs) that regulate numerous essential biological processes such as differentiation, development, physiology, reproduction, and cellular metabolism. Dysregulation and anomalous expression of different NRs has led to multiple alterations, such as impaired signaling cascades, mutations, and epigenetic changes, leading to various diseases, including cancer. It has been observed that differential expression of various NRs might lead to the initiation and progression of CRC, and are correlated with poor survival outcomes in CRC patients. Despite numerous studies on the mechanism and role of NRs in this cancer, it remains of significant scientific interest primarily due to the diverse functions that various NRs exhibit in regulating key hallmarks of this cancer. Thus, modulating the expression of NRs with their agonists and antagonists, based on their expression levels, holds an immense prospect in the diagnosis, prognosis, and therapeutical modalities of CRC. In this review, we primarily focus on the role and mechanism of NRs in the pathogenesis of CRC and emphasized the significance of targeting these NRs using a variety of agents, which may represent a novel and effective strategy for the prevention and treatment of this cancer. Graphical Abstract

show abstract

“…Until now, only a few circulating mRNA markers have been reported. For example, tyrosinase mRNA can be detected in the blood of some melanoma patients (10); telomerase mRNAs can be detected in breast cancer patients (11), CK19, mammaglobin, 5T4, and circulating thyroid-stimulating hormone receptor (TSHR) mRNAs can be detected in thyroid cancer patients (12); 5T4 mRNA can be detected in lung cancer patients (13); and CEA and CK19 mRNAs can be detected in colorectal cancer patients (14). These studies have revealed that circulating mRNAs can be potential biomarkers.…”

mentioning

confidence: 99%

Transcriptomic Analysis in Liquid Biopsy Identifies Circulating PCTAIRE-1 mRNA as a Biomarker in NSCLC

Chang

Shih

Wang

et al. 2019

Cancer Genomics Proteomics

View full text Add to dashboard Cite

Background/Aim: Circulating mRNA can be a useful source of cancer biomarkers. We took advantage of direct transcriptomic analysis in plasma RNA to identify novel mRNA markers for non-small cell lung cancer (NSCLC). Patients and Methods: Plasma RNA from NSCLC patients and healthy individuals was profiled with cDNAmediated annealing, selection, extension and ligation (DASL) microarrays. The microarray results were further validated in plasma RNA. Results: Through RNA profiling and online database mining, four gene transcripts were filtered as candidate markers of NSCLC. After validation, the PCTAIRE-1 transcript was identified as a circulating mRNA marker. The diagnostic potential of PCTAIRE-1 was evaluated by receiver operating characteristic curve analysis, which gave a sensitivity and specificity of 60% and 85%, respectively. In addition, high plasma PCTK1 levels were also correlated with poor progression-free survival (p=0.008). Conclusion: Circulating mRNA can be profiled with the DASL assay. From the profile, PCTAIRE-1 RNA in the plasma we discovered as a novel diagnostic/prognostic biomarker and an indicator of poor survival in NSCLC patients.

show abstract

Circulating thyroid stimulating hormone receptor messenger RNA and differentiated thyroid cancer: A diagnostic meta-analysis

Cited by 5 publications

References 34 publications

Meta-analysis reveals gender difference in the association of liver cancer incidence and excess BMI

Meta-analysis reveals gender difference in the association of liver cancer incidence and excess BMI

Delineating the role of nuclear receptors in colorectal cancer, a focused review

Transcriptomic Analysis in Liquid Biopsy Identifies Circulating PCTAIRE-1 mRNA as a Biomarker in NSCLC

Contact Info

Product

Resources

About