Circulating T and B lymphocytes of the mouse

Sprent, J.

doi:10.1016/0008-8749(73)90180-9

Cited by 364 publications

(129 citation statements)

References 33 publications

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“…Although the role and fate of B cell precursors in the thymus have not become clear from our experiments, several observations by other investigators suggest that they are differentiative and pooled in the periphery: it is known that neonatally thymectomy causes a sudden disappearance of circulating B cells [33] and, in nude mice, the frequency of B cells susceptible to the transformation by A-MuLV is significantly reduced as compared to conventional strains [16,32,34]. In this regard, of interest is the finding that B cell deficiency is induced in xidl nude mice [34-361.…”

Section: B Cell Precursors Are Present In Fetal Thymusmentioning

confidence: 83%

B cell precursors are present in the thymus during early development

et al. 1989

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An in vitro system for transforming immature lymphoid cells present in the thymus at early development has been established. By phenotype analysis of the transformants obtained, we observed that B cell precursors, susceptible to Abelson murine leukemia virus (A-MuLV)- or Harvey murine sarcoma virus (H-MuSV)-induced lymphogenesis, were present at high frequency in the fetal thymus of BALB/c mice. These precursors recolonized alymphoid thymus lobes in vitro, as do T cell precursors. It was further observed that B precursors in the fetal liver were also capable of recolonizing alymphoid thymus lobes and were stored in a thymic environment. These results suggest that stroma cells of the fetal thymus may possess the capacity to support the growth of B precursors. On the other hand, B cell precursors sensitive to the viral transformation were undetectable in the fetal thymus of C57BL/6, although immunohistochemical analysis suggested their presence. However, in the fetal liver of the same strain, B precursors recolonizing alymphoid thymus in vitro were sensitive to the viral transformation. Based on these results, we will discuss both the role and fate of thymic B precursors. In addition, we also obtained T cell lymphomas at different stages of differentiation from the fetal thymus of C57BL/6 infected with A-MuLV or H-MuSV. These data indicate the usefulness of our system in establishing cell lines derived from intrathymic lymphogenesis at early development.

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Section: B Cell Precursors Are Present In Fetal Thymusmentioning

confidence: 83%

B cell precursors are present in the thymus during early development

et al. 1989

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“…In vivo labeling studies have demonstrated that developing BM B cells and transitional B cells in the periphery have high turnover rates, consistent with short residency times and vulnerability to positive and negative selection [28,[54][55][56][57][58]. The steady-state numbers of mature follicular and marginal zone B cells reflect the input of transitional B cells that successfully complete maturation, and the comparatively slower turnover of these mature B cells [54,[58][59][60]. Thus, as previously discussed, perturbations to B cell genesis have consequences for all naïve subsets, with the length and severity determining the extent to which mature B cell pools are affected.…”

Section: The Blys Family Contributes To the Maintenance Of Peripheralmentioning

confidence: 99%

Spinal cord injury impacts B cell production, homeostasis, and activation

Oropallo

Goenka

Cancro

2014

Seminars in Immunology

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“…At normal steady state, most surviving TR cells enter the follicular (FO) compartment, with a small proportion joining the marginal zone (MZ) pool. Cells within the FO pool display a relatively long half-life of 80-120 days [4,120].…”

Section: Primary B Cell Pool Sizes Are Maintained By Competition In Tmentioning

confidence: 99%

Manipulating B cell homeostasis: a key component in the advancement of targeted strategies

Treml

Quinn

Treml

et al. 2008

Arch. Immunol. Ther. Exp.

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Understanding the homeostatic mechanisms governing lymphocyte pools achieves critical importance as lymphocyte-targeted therapies expand in use and scope. The primacy of B lymphocyte stimulator (BLyS) family ligands and receptors in governing B lymphocyte homeostasis has become increasingly clear in recent years, affording insight into novel opportunities and potential pitfalls for targeted B cell therapeutics. Interclonal competition for BLyS-BR3 interactions determines the size of naïve B cell pools and can regulate the stringency of selection applied as cells complete maturation. Thus one of the predicted consequences of ablative therapies targeting primary pools is relaxed negative selection. This suggests that BLyS levels and B cell reconstitution rates may serve useful prognostic roles and that BLyS itself might be targeted to circumvent relapse. Alternatively, manipulations that allow rare, minimally autoreactive specificities to survive and mature may lead to opportunities in cases where antibody-based vaccine development has heretofore been unsuccessful. BLyS family ligands and receptors also play a role in activated and memory B cell pools, suggesting they might likewise be targeted to promote or delete particular antigen-experienced subpopulations in a similar way.

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Circulating T and B lymphocytes of the mouse

Cited by 364 publications

References 33 publications

B cell precursors are present in the thymus during early development

B cell precursors are present in the thymus during early development

Spinal cord injury impacts B cell production, homeostasis, and activation

Manipulating B cell homeostasis: a key component in the advancement of targeted strategies

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