Circulating plasma microRNA profiling in patients with polymyositis/dermatomyositis before and after treatment: miRNA may be associated with polymyositis/dermatomyositis

Hirai, Takuya; Ikeda, Keigo; Tsushima, Hirofumi; Fujishiro, Midori; Hayakawa, Kunihiro; Yoshida, Yuko; Morimoto, Shinji; Yamaji, Katsuhiko; Takasaki, Yoshinari; Takamori, Kenji; Tamura, Naoto; Sekigawa, Iwao

doi:10.1186/s41232-017-0058-1

Cited by 45 publications

(47 citation statements)

References 24 publications

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“… [ 257 ] miRNA Plasma levels of hsa-miR-4442 in active PM and DM are very high. [ 258 ] miR-206 is decreased in DM patients. It is necessary for differentiation and maintenance of adult skeletal muscle.…”

Section: Epigenetic Factorsmentioning

confidence: 99%

Identifying the culprits in neurological autoimmune diseases

Acosta-Ampudia

Monsalve

Ramírez-Santana

2019

Journal of Translational Autoimmunity

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The target organ of neurological autoimmune diseases (NADs) is the central or peripheral nervous system. Multiple sclerosis (MS) is the most common NAD, whereas Guillain-Barré syndrome (GBS), myasthenia gravis (MG), and neuromyelitis optica (NMO) are less common NADs, but the incidence of these diseases has increased exponentially in the last few years. The identification of a specific culprit in NADs is challenging since a myriad of triggering factors interplay with each other to cause an autoimmune response. Among the factors that have been associated with NADs are genetic susceptibility, epigenetic mechanisms, and environmental factors such as infection, microbiota, vitamins, etc. This review focuses on the most studied culprits as well as the mechanisms used by these to trigger NADs.

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Section: Epigenetic Factorsmentioning

confidence: 99%

Identifying the culprits in neurological autoimmune diseases

Acosta-Ampudia

Monsalve

Ramírez-Santana

2019

Journal of Translational Autoimmunity

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“…There were several studies which investigated the correlations between serum microRNAs and clinical phenotypes in DM patients (Table 3) [8, 11, 23–25]. Inoue and colleagues suggested that the serum and the skin expression of miR-233 were both downregulated in DM patients with Gottron's papules and clinically amyopathic DM patients [24].…”

Section: Discussionmentioning

confidence: 99%

Specific Autoantibodies and Clinical Phenotypes Correlate with the Aberrant Expression of Immune-Related MicroRNAs in Dermatomyositis

Zuo

Yang

et al. 2019

Journal of Immunology Research

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Aims. The serum concentrations of miRNAs, miR-23a-3p, miR-23b-3p, miR-146a-5p, miR-146b-5p, and miR-150-5p, were shown to be associated with the immune and inflammatory progressions. We assessed the expressions of these five miRNAs in association with clinical phenotypes and myositis-specific autoantibody-defined subgroups of dermatomyositis (DM). Methods. The present study included 49 patients with DM and 30 healthy controls. The serum concentrations of miR-23a-3p, miR-23b-3p, miR-146a-5p, miR-146b-5p, and miR-150-5p were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Associations between the serum concentrations of miRNAs and DM clinical immune phenotypes were examined as well. Results. The serum concentrations of miR-23b-3p, miR-146a-5p, and miR-150-5p were significantly downregulated in DM patients (P<0.001, P<0.001, and P=0.002, respectively), while miR-146b-5p was remarkably upregulated in DM patients compared with healthy controls (P=0.039). Similarly, the expressions of miR-23b-3p, miR-146a-5p, and miR-150-5p were significantly downregulated in the peripheral blood mononuclear cells (PBMCs) from DM patients. Further study indicated that the serum level of miR-23b-3p was significantly correlated with creatine kinase (CK) (r=−0.286, P=0.046) and the serum level of miR-146a-5p was evidently correlated with C-reactive protein (CRP) (r=−0.358, P=0.012). Significant correlations were also observed between the serum levels of miR-146b-5p and CRP (r=−0.347, P=0.014) and the erythrocyte sedimentation rate (ESR) (r=−0.287, P=0.046). In addition, the expression level of miR-146b-5p was upregulated in DM complicated by tumors compared with those without tumors (P=0.001 and P<0.001, respectively). Especially, miR-150-5p was significantly downregulated in DM patients with anti-MDA5 antibodies and anti-NXP2 antibodies compared with those without (P=0.017 and P=0.047, respectively). No significant differences were observed between the four serum microRNAs in patients with and without interstitial lung diseases (all P>0.05). Conclusion. The results suggest an association between the four immune-related microRNAs and different clinical immune-phenotypes, and this association may regulate the complexity of disease processes through multipathways in DM patients.

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“…The pathogenic roles of microRNAs have been extensively investigated in malignant diseases as well as in autoimmune disorders. Although many microRNAs levels altered in PM/DM patients after treatment, little study reported the role of microRNA in PM/DM (8). So far, miR-21, miR-381, and miR-146a have been reported to regulate macrophage migration in PM/DM (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%