Circulating PCSK9 levels and conventional risk factors in CAD

Abstract

Coronary artery disease (CAD) is the chief cause of mortality and morbidity worldwide. The aim of this study was to compare the levels PCSK9 and conventional risk factors of CAD in CAD patients and age and sex-matched controls and also to evaluate the relationship of circulating PCSK9 levels with other conventional risk factors of coronary artery patients. Sixty two clinically proved CAD patients and sixty-two healthy; age and sex-matched subjects without CAD were selected for the study. Detailed clinical and other relevant data were recorded using proforma. Five ml of fasting venous blood was collected from all the subjects and used for the investigations of fasting plasma glucose (FPG), HBA1C, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol (Direct), Apo B and PCSK9. The outcomes of this study showed that levels of FPG, HbA1c, lipid parameters-total cholesterol, triglycerides, LDL-c, Apo B were significantly higher whereas HDL-c were significantly low in CAD patients compared to normal controls. Circulating PCSK9 level was significantly elevated, and its level was correlated with other risk parameters. This study found that circulating PCSK9 level was significantly high, and its level was correlated with other risk parameters.