Circulating P-Selectin and Its Glycoprotein Ligand in Nondiabetic Obstructive Sleep Apnea Patients

Winiarska, Hanna; Cofta, Szczepan; Bielawska, Lena; Płóciniczak, Alicja; Piorunek, Tomasz; Wysocka, Ewa

doi:10.1007/5584_2020_501

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…Platelets contain many cell adhesion and inflammatory factors that can be released when they are activated, including soluble CD40 ligand (sCD40L) and P-selectin. In different studies, subjects with OSA have found platelet activity to be increased in these patients [ 56 , 57 , 58 ] and correlated with an increase in sCD40L [ 59 , 60 , 61 ] and P-selectin [ 62 , 63 , 64 , 65 ] levels. A few minutes after activation, platelet aggregation is observed.…”

Section: Osa and The “Hypercoagulable State”mentioning

confidence: 99%

Obstructive Sleep Apnea, Hypercoagulability, and the Blood–Brain Barrier

Zolotoff

Bertoletti

Gozal

et al. 2021

JCM

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Obstructive sleep apnea (OSA) is characterized by repeated episodes of intermittent hypoxia (IH) and is recognized as an independent risk factor for vascular diseases that are mediated by a multitude of mechanistic pathophysiological cascades including procoagulant factors. The pro-coagulant state contributes to the development of blood clots and to the increase in the permeability of the blood–brain barrier (BBB). Such alteration of BBB may alter brain function and increase the risk of neurodegenerative diseases. We aim to provide a narrative review of the relationship between the hypercoagulable state, observed in OSA and characterized by increased coagulation factor activity, as well as platelet activation, and the underlying neural dysfunction, as related to disruption of the BBB. We aim to provide a critical overview of the existing evidence about the effect of OSA on the coagulation balance (characterized by increased coagulation factor activity and platelet activation) as on the BBB. Then, we will present the emerging data on the effect of BBB disruption on the risk of underlying neural dysfunction. Finally, we will discuss the potential of OSA therapy on the coagulation balance and the improvement of BBB.

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Section: Osa and The “Hypercoagulable State”mentioning

confidence: 99%

Obstructive Sleep Apnea, Hypercoagulability, and the Blood–Brain Barrier

Zolotoff

Bertoletti

Gozal

et al. 2021

JCM

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“…Even though the surface selectins remain unchanged, the increased soluble forms may be considered as markers of inflammation of vascular wall with prothrombic activity. Another study confirms that serum content of platelet P-selectin and P-selectin glycoprotein ligand 1 are increased proportionally with OSA severity [ 106 ]. CPAP significantly decreased serum levels of sCD40L and sP-selectin in patients with moderate to severe OSA [ 107 , 108 ].…”

Section: Platelet Functionmentioning

confidence: 72%

Cardiovascular Disorders Triggered by Obstructive Sleep Apnea—A Focus on Endothelium and Blood Components

Mochol

Gawryś

Gajecki

et al. 2021

IJMS

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Obstructive sleep apnea (OSA) is known to be an independent cardiovascular risk factor. Among arousal from sleep, increased thoracic pressure and enhanced sympathetic activation, intermittent hypoxia is now considered as one of the most important pathophysiological mechanisms contributing to the development of endothelial dysfunction. Nevertheless, not much is known about blood components, which justifies the current review. This review focuses on molecular mechanisms triggered by sleep apnea. The recurrent periods of hypoxemia followed by reoxygenation promote reactive oxygen species (ROS) overproduction and increase inflammatory response. In this review paper we also intend to summarize the effect of treatment with continuous positive airway pressure (CPAP) on changes in the profile of the endothelial function and its subsequent potential clinical advantage in lowering cardiovascular risk in other comorbidities such as diabetes, atherosclerosis, hypertension, atrial fibrillation. Moreover, this paper is aimed at explaining how the presence of OSA may affect platelet function and exert effects on rheological activity of erythrocytes, which could also be the key to explaining an increased risk of stroke.

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“…In line, we previously demonstrated a systemic inflammation in OSA patients resulting from the inflammasome activation ( 42 , 43 ), also, others authors reported the low-grade-chronic inflammatory state in these patients ( 44 – 49 ). On the other hand, there are two studies in OSA patients focusing on potential role of circulating PSGL-1, as a driver of leucocyte infiltration facilitating the development of atherosclerosis; however, assessing PSGL-1 circulating levels provided discrepant results ( 50 , 51 ). Particularly, Horvath et al., reported no differences on circulating PSGL-1 levels, while Winiarska et al., concluded that circulating PSGL-1 levels were significantly increased in OSA patients and correlated with AHI.…”

Section: Discussionmentioning

confidence: 99%

PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea

Díaz-García,

García-Sánchez,

Alfaro

et al. 2023

Front. Immunol.

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IntroductionAlthough higher incidence of cancer represents a major burden for obstructive sleep apnea (OSA) patients, the molecular pathways driving this association are not completely understood. Recently, the adhesion receptor P-selectin glycoprotein-1 (PSGL 1) has been identified as a novel immune checkpoint, which are recognized major hallmarks in several types of cancer and have revolutionized cancer therapy.MethodsThe expression of PSGL-1 and its ligands VISTA and SIGLEC-5 was assessed in the leucocytes of OSA patients and control subjects exploring the role of intermittent hypoxia (IH) using in vitro models. In addition, PSGL-1 impact on T-cells function was evaluated by ex vivo models.ResultsData showed PSGL-1 expression is upregulated in the T-lymphocytes from patients with severe OSA, indicating a relevant role of hypoxemia mediated by intermittent hypoxia. Besides, results suggest an inhibitory role of PSGL-1 on T-cell proliferation capacity. Finally, the expression of SIGLEC-5 but not VISTA was increased in monocytes from OSA patients, suggesting a regulatory role of intermittent hypoxia.DiscussionIn conclusion, PSGL-1 might constitute an additional immune checkpoint leading to T-cell dysfunction in OSA patients, contributing to the disruption of immune surveillance, which might provide biological plausibility to the higher incidence and aggressiveness of several tumors in these patients.

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Circulating P-Selectin and Its Glycoprotein Ligand in Nondiabetic Obstructive Sleep Apnea Patients

Cited by 6 publications

References 35 publications

Obstructive Sleep Apnea, Hypercoagulability, and the Blood–Brain Barrier

Obstructive Sleep Apnea, Hypercoagulability, and the Blood–Brain Barrier

Cardiovascular Disorders Triggered by Obstructive Sleep Apnea—A Focus on Endothelium and Blood Components

PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea

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